Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Ketoconazole | Cytochrome P450 Inhibitor
From $45.00CAS:65277-42-1Catalog Number:10-1015Activity:Cytochrome P450 inhibitorChemical Name:(±)-1-[4-(4-{[-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-oneMolecular Weight:531.43Molecular Formula:C26H28Cl2N4O4Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Off-white solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Lamivudine | Reverse transcriptase inhibitor
From $45.00CAS:134678-17-4Catalog Number:10-2028Activity:Reverse transcriptase inhibitorChemical Names:4-Amino-1-[(2R,5S)-2-(hydroxymethyl)1,3-oxathiolan-5-yl]-2(1H)-pyrimidinoneAlternate Name:(-)-BCH-189; 3TCMolecular Weight:229.25Molecular Formula:C8H11N3O3SSolubility:Soluble in DMSO (30 mg/ml)Physical Properties:Off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Lapatinib (base) | EGFR and HER2 inhibitor
From $55.00CAS:231277-92-2Catalog Number:10-2147Activity:EGFR and HER2 inhibitorChemical Name:N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amineAlternate Names:GW-572016Molecular Weight:581.06Molecular Formula:C29H26ClFN4O4SSolubility:Soluble in DMSO (up to 200 mg/ml)Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Larotrectinib | TRK inhibitor
From $60.00CAS:1223403-58-4Catalog Number:10-4832Activity:Potent and selective panTRK inhibitorChemical Name:(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamideAlternate Name:LOXO-101; ARRY-470Molecular Weight:428.44Molecular Formula:C21H22F2N5O2Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
Leflunomide | Immunosuppressant
From $40.00CAS:75706-12-6Catalog Number:10-2369Activity:ImmunosuppressantAlternate Names:RS-34821Chemical Name:5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamideMolecular Weight:270.21Molecular Formula:C12H9F3N2O2Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
