Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Methotrexate | Dihydrofolate reductase inhibitor
From $50.00CAS:133073-73-1Catalog Number:10-1260Activity:Dihydrofolate reductase inhibitorChemical Names:N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740Molecular Weight:683.63Molecular Formula:C20H22N8O5·XH2OSolubility:Soluble in DMSO (45 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Metolazone | UPR activator and longevity inducer
From $50.00CAS:17560-51-9Catalog Number:10-5417Activity:UPR activator and longevity inducerChemical Name:7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Molecular Weight:365.83Molecular Formula:C16H16ClN3O3SSolubility:Soluble in DMSO (up to 36 mg/ml)Physical Properties:White solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.Shipping Code:RT -
Metyrapone | Cytochrome P450 inhibitor
From $30.00CAS:54-36-4Catalog Number:10-1159Activity:Cytochrome P450 inhibitorChemical Name:2-Methyl-1,2-dipyridin-3-yl-propan-1-oneMolecular Weight:226.27Molecular Formula:C14H14N2OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Mifepristone | Glucocorticoid antagonist
From $50.00CAS:84371-65-3Catalog Number:10-1053Activity:Glucocorticoid antagonistAlternate Names:RU486Chemical Name:11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-oneMolecular Weight:429.59Molecular Formula:C29H35NO2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
CAS:75172-81-5Catalog Number:10-2632 -
Miglitol | beta-glucosidase inhibitor / antidiabetic
From $70.00CAS:72432-03-2Catalog Number:10-2332Activity:α-glucosidase inhibitor / antidiabeticAlternate Names:N-(2-Hydroxyethyl)-1-deoxynojirimycin; BAY-1099Chemical Name:(2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triolMolecular Weight:207.23Molecular Formula:C8H17NO5Solubility:Soluble in DMSO (up to 50 mg/ml with warming), or in Water (up to 60 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.Shipping Code:RT
