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Ubiquitin / Proteasome

The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.

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DUBs

  • P22077

    P22077 is a selective USP7 inhibitor

  • WP1130

    Inhibits USP5, 9x, 14, and UCH37

  • LDN-57444

    LDN-57444 inhibits the ubiquitin C-terminal hydrolase (UCH-L1).

View All DUB Reagents

E3 Ubiquitin Ligase

  • Heclin

    Heclin is an inhibitor of the HECT domain-containing E3 ubiquitin ligases

  • Pomalidomide

    A thalidomide analog that inhibits the E3 ubiquitin ligase cereblon.

View All E3 Ubiquitin Ligase Reagents

Proteasome

  • Epoxomicin

    Potent, selective, and irreversible inhibitor of the 20S proteasome

  • Carfilzomib

    Carfilzomib is a potent and irreversible proteasome inhibitor

  • MG-132

    MG-132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome

View All Proteasome Reagents

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