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  • Focus Biomolecules chemical structure 2'-Deoxy-5-fluorocytidine | DNA methyl transferase inhibitor | CAS 10356-76-0
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 4-HQN | PARP inhibitor | CAS 491-36-1
    $30.00
    4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent...

  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • Focus Biomolecules supplier, chemical structure of 8-Oxo-2'-deoxyguanosine | Marker for DNA damage | CAS 88847-89-6
    $38.00
    8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3. References/Citations1) Beckman et al...

  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cisplatin | Anticancer agent | CAS 15663-27-1
    $50.00
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    $60.00
    Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances...

  • Focus Biomolecules cell signaling supplier, chemical structure of Epirubicin HCl | DNA damaging agent | CAS 56390-09-1
    $48.00
    Epirubicin HCl (56390-09-1) is an antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with...

  • FQI1 | LSF inhibitor
    $70.00
    FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular...

  • Focus Biomolecules supplier, chemical structure of Gemcitabine HCl | DNA polymerase inhibitor | CAS 122111-03-9
    $30.00
    Gemcitabine HCl (122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of...

  • Focus Biomolecules cell signaling supplier, chemical structure of Herboxidiene | Spliceosome inhibitor | CAS 142861-00-5
    $80.00
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Iniparib | PARP inhibitor | CAS 160003-66-7
    $65.00
    Iniparib (160003-66-7) was originally thought to be a PARP1 inhibitor but this is controversial.1,2 Inhibits ionizing radiation-induced single-stranded DNA break repair in lymphoid cell lines in vivo.3 Inhibits growth of...

  • Focus Biomolecules supplier, chemical structure of Irinotecan HCl | Topoisomerase I inhibitor | CAS 136572-09-3
    $60.00
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...

  • Focus Biomolecules cell signaling tech supplier, structure of Mitomycin C | DNA crosslinking & damaging agent | CAS 50-07-7
    $45.00
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Olaparib | PARP1 inhibitor | CAS 763113-22-0
    $40.00
    Olaparib (763113-22-0) is a highly potent and selective PARP-inhibitor with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively.1  In a genetically engineered mouse model for BRCA1-associated breast cancer...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of RI-1 | RAD51 inhibitor | CAS 415713-60-9
    $52.00
    RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells...

  • Rucaparib phosphate | PARP1 inhibitor
    $70.00
    Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26...

  • Focus Biomolecules cell signaling tech supplier, chemical structure SN-38 | DNA topoisomerase I inhibitor | CAS 86639-52-3
    $75.00
    SN-38 (86639-52-3) is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Temozolomide | Autophagy inducer | CAS 85622-93-1
    $75.00
    Temozolomide (85622-93-1) is a DNA alkylating agent with antitumor and antiangiogenic activity.1,2 Clinically useful anticancer agent.3 Temozolomide induces autophagy in a variety of cell lines.4 Cell...

  • Focus Biomolecules reagent supplier, chemical structure of Trifluorothymidine | Thymidylate synthase inhibitor | CAS 70-00-8
    $45.00
    Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2  After phosphorylation by thymidine kinase, it is incorporated into DNA where it...

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