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Immunology

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  • Alpha-Mangostin | STING agonist (human)
    $50.00
    α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates...

  • C-176 | STING Antagonist
    $50.00
    C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176...

  • C-178 | STING Antagonist
    $50.00
    C-178 (329198-87-0) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. References/Citations 1) Haag et al...

  • Defactinib | Potent FAK Inhibitor
    $65.00
    Defactinib is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has...

  • DMXAA | STING agonist
    $60.00
    DMXAA (117570-53-3) is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING.1,2 Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts.3 Tumor...

  • Duvelisib | PI3Kd/g Inhibitor/ Cancer Immunotherapy Enhancer
    $75.00
    Duvelisib is a potent and selective (IC50’s: PI3Ka = 1602nM, PI3Kb = 85nM, PI3Kd = 2.5nM, PI3Kg = 27nM) dual PI3Kd/g inhibitor.1 It inhibits B and T cell proliferation, blocks neutrophil migration, and inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    $60.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • Galunisertib | Potent TGFB receptor 1 inhibitor / Cancer immunotherapeutic
    $50.00
    Galunisertib (700874-72-2) is a TGF-β kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in...

  • H-151 | STING Antagonist
    $65.00
    H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine...

  • Idelalisib | Selective PI3Kd Inhibitor
    $60.00
    Idelalisib is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates...

  • Indoximod | IDO modulator / tryptophan mimetic
    $20.00
    Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer...

  • Ingenol-3-angelate | PKC activator
    $110.00
    Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated...

  • IPI-549 | Selective PI3Kgamma inhibitor / Immuno-oncology agent
    $65.00
    IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays.1 Macrophage PI3K-γ has been found to be a critical switch...

  • Kynurenine (L) | Endogenous AhR agonist
    $38.00
    Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan...

  • Lenalidomide | Immunomodulator
    $35.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Pexidartinib | CSF1R inhibitor/Cancer Imunotherapy Enhancer
    $40.00
    Pexidartinib is a potent and selective dual inhibitor of CSF1R (IC50 = 20nM) and c-KIT (IC50 = 10nM).1 Inhibition of CSF1R with Pexidartinib resulted in a reprogrammed immune microenvironment that fosters antitumor immunity...

  • PF-06840003 | IDO1 Inhibitor/Cancer Immunotherapy Enhancer
    $60.00
    PF-06840003 is potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%,...

  • R428 | Potent and Selective AXL Inhibitor
    $120.00
    R428 is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM).1 R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models.2-5 AXL has been shown to suppress myeloid cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9
    $100.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Sitravatinib | Multikinase inhibitor / Immuno-oncology agent
    $50.00
    Sitravatinib (1123837-84-2) is a broad spectrum receptor tyrosine kinase inhibitor. Its targets include Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3 among others at nanomolar levels.1 Sitravatinib has been...

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