PhysioProcesses

Cancer

Cancer is a collection of related genetic diseases that cause cells to divide uncontrollably and spread to surrounding tissues. Phenotypic changes to cancer cells include abnormal shape, fast rate of division, high metabolic rate, and invasion of surrounding tissues. The aberrant genes that lead to cancer can arise from DNA damage caused by environmental sources, errors that occur during cell division, or inherited. Tumor promoting genetic mutations occur in oncogenes that activate pathways related to cell proliferation or inactivate cell death pathways. Mutations in tumor suppressor genes lead to loss of function in growth inhibition, DNA damage repair, and apoptosis activation pathways.

Angiogenesis

  • E7820 | RBM39 molecular glue
    CAS:
    289483-69-8
    Catalog Number:
    10-3935
  • ABT-869 | Dual VEGFR and PDGFR kinase inhibitor
    CAS:
    796967-16-3
    Catalog Number:
    10-5268
  • Vandetanib | VEGFR2 inhibitor
    CAS:
    443913-73-3
    Catalog Number:
    10-2185
    Activity:
    VEGFR2 inhibitor
    Chemical Names:
    4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
    Alternate Name:
    ZD6474
    Molecular Weight:
    475.35
    Molecular Formula:
    C22H24BrFN4O2
    Solubility:
    Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
    CAS:
    2188-68-3
    Catalog Number:
    10-2608
    Activity:
    Protein synthesis inhibitor/SCAP degrader
    Chemical Names:
    Galanthidine; Amarylline; Narcissine
    Molecular Weight:
    323.77
    Molecular Formula:
    C16H17NO4·HCl
    Solubility:
    Soluble in water (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • FAK inhibitor 14 | FAK inhibitor
    CAS:
    4506-66-5
    Catalog Number:
    10-2547
    Activity:
    FAK inhibitor
    Alternate Names:
    Y15
    Chemical Name:
    1,2,4,5-Benzenetetramine tetrahydrochloride
    Molecular Weight:
    284.02
    Molecular Formula:
    C6H10N4 4HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).
    Physical Properties:
    Grey solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Angiogenesis Products

Autophagy

  • PF-543 HCl | Sphingosine kinase-1 inhibitor
    CAS:
    1706522-79-3
    Catalog Number:
    10-4998
  • Vacuolin-1 | Autophagy/PIKfyve inhibitor
    CAS:
    351986-85-1
    Catalog Number:
    10-5151
  • Verteporfen | YAP Inhibitor
    CAS:
    129497-78-5
    Catalog Number:
    10-3487
    Activity:
    YAP inhibitor
    Chemical Names:
    (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
    Alternate Name:
    CL 318,952; BPD-MA
    Molecular Weight:
    718.79
    Molecular Formula:
    C41H42N4O8
    Solubility:
    Soluble in DMSO (up to 14 mg/ml)
    Physical Properties:
    Black solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Torin1 | mTOR inhibitor
    CAS:
    1222998-36-8
    Catalog Number:
    10-3013
    Activity:
    mTOR inhibitor
    Chemical Name:
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
    Molecular Weight:
    607.62
    Molecular Formula:
    C35H28F3N5O2
    Solubility:
    Soluble in DMSO (up to 8 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity
    CAS:
    159989-65-8
    Catalog Number:
    10-3050
    Activity:
    HIV protease inhibtior / Anticancer activity
    Chemical Name:
    (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
    Alternate Name:
    AG-1343
    Molecular Weight:
    663.88
    Molecular Formula:
    C32H45N3O4S • CH3SO3H
    Solubility:
    Soluble in DMSO (up to 70 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Autophagy Products

Cancer Cell Metabolism

View All Cancer Cell Metabolism Products

Cancer Stem Cells

  • STF-118804 | NAMPT inhibitor
    CAS:
    894187-61-2
    Catalog Number:
    10-5640
  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • Sulconazole | Antifungal/ Prevents cancer stem cell formation
    CAS:
    61318-91-0
    Catalog Number:
    10-3955
    Activity:
    Antifungal/Prevents cancer stem cell formation
    Chemical Names:
    1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
    Molecular Weight:
    460.75
    Molecular Formula:
    C18H15Cl3N2S·HNO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Nitisinone | Tyrosine metabolism inhibitor
    CAS:
    104206-65-7
    Catalog Number:
    10-4648
    Activity:
    Tyrosine metabolism inhibitor
    Chemical Names:
    2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
    Alternate Name:
    NTBC
    Molecular Weight:
    329.23
    Molecular Formula:
    C14H10F3NO5
    Solubility:
    Soluble in DMSO (at least 70 mg/ml); ethanol (10 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
    CAS:
    83280-65-3
    Catalog Number:
    10-3442
    Activity:
    STAT3 inhibitor / Cancer cell stemness inhibitor
    Chemical Name:
    2-Acetylnsphtho[2,3-b]furan-4,9-dione
    Alternate Names:
    BBI608
    Molecular Weight:
    240.21
    Molecular Formula:
    C14H8O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cancer Stem Cells Products

Cell Cycle

  • ICRF-193 | Topoisomerase II poison
    CAS:
    21416-88-6
    Catalog Number:
    10-5056
  • SKPin C1 | Ubiquitin ligase E3 SCF-Skp2 inhibitor
    CAS:
    432001-69-9
    Catalog Number:
    10-1441
    Activity:
    Ubiquitin ligase E3 SCF-Skp2 inhibitor
    Chemical Names:
    2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl¬methyl)-2-thioxo-5-thiazolidinylidene]methyl]-phenoxy]acetic acid
    Molecular Weight:
    465.34
    Molecular Formula:
    C18H13BrN2O4S2
    Solubility:
    Soluble in DMSO (15 mg/ml with warming)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • WM-1119 | HAT KAT6A inhibitor
    CAS:
    2055397-28-7
    Catalog Number:
    10-4013
  • SU9516 | pan-specific CDK inhibitor
    CAS:
    SU9516
    Catalog Number:
    10-5705
    Activity:
    pan-specific CDK inhibitor
    Chemical Names:
    (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
    Molecular Weight:
    241.25
    Molecular Formula:
    C13H11N3O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • NG52 | Phosphoglycerate kinase 1 inhibitor
    CAS:
    212779-48-1
    Catalog Number:
    10-4681
    Activity:
    Phosphoglycerate kinase 1 inhibitor
    Chemical Names:
    2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
    Molecular Weight:
    346.82
    Molecular Formula:
    C16H19ClN6O
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cell Cycle Products

Cellular Stress

  • MitoBloCK-10 | TIMM44 blocker
    CAS:
    394694-98-5
    Catalog Number:
    10-5324
  • Honokiol-DCA | TRAP1 Inhibitor
    CAS:
    1620160-42-0
    Catalog Number:
    10-3596
  • Luminespib | HSP90 inhibitor
    CAS:
    747412-49-3
    Catalog Number:
    10-4672
    Activity:
    HSP90 inhibitor
    Chemical Names:
    5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
    Alternate Name:
    NVP-AUY922; VER-52296
    Molecular Weight:
    465.54
    Molecular Formula:
    C26H31N3O5
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SRS16-86 | Ferroptosis inhibitor
    CAS:
    1793052-96-6
    Catalog Number:
    10-4668
    Activity:
    Ferroptosis inhibitor
    Chemical Names:
    tert-Butyl 4-(1-adamantylamino)-3-(pyrimidin-5-ylmethylideneamino)benzoate
    Molecular Weight:
    432.57
    Molecular Formula:
    C26H32N4O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Cellular Stress Products

Chemotherapeutics

View All Chemotherapeutics Products

Cytoskeleton

  • Dynarrestin | Cytoplasmic dynein 1/2 inhibitor
    CAS:
    2222768-84-3
    Catalog Number:
    10-4196
  • Cytochalasin B | Actin filament disrupting agent
    CAS:
    14930-96-2
    Catalog Number:
    10-2069
    Activity:
    Actin filament disrupting agent
    Fermentation product:
    from Drechslera dematioidea
    Alternate Name:
    NSC107658; Phominone
    Molecular Weight:
    479.61
    Molecular Formula:
    C29H37NO5
    Solubility:
    Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Buparlisib | PI3-kinase inhibitor
    CAS:
    944396-07-0
    Catalog Number:
    10-4325
    Activity:
    pan-Class I PI3-kinase inhibitor
    Chemical Names:
    5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine; NVP-BKM120
    Molecular Weight:
    410.39
    Molecular Formula:
    C18H21F3N6O2
    Solubility:
    Soluble in DMSO (15 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Griseofulvin | Inhibitor of centrosomal clustering
    CAS:
    126-07-8
    Catalog Number:
    10-2745
    Activity:
    Inhibitor of centrosomal clustering
    Chemical Name:
    Fermentation product from Penicili>ium sp.
    Molecular Weight:
    352.77
    Molecular Formula:
    C17H17ClO6
    Solubility:
    Soluble in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Vincristine sulfate | Microtubule depolymerizer
    CAS:
    2068-78-2
    Catalog Number:
    10-2570
    Activity:
    Microtubule depolymerizer
    Alternate Names:
    Leurocristine sulfate
    Chemical Name:
    22-Oxovincaleukoblastine sulfate
    Molecular Weight:
    923.06
    Molecular Formula:
    C46H56N4O10
    Solubility:
    Soluble in Water (up to 80 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Cytoskeleton Products

DNA Damage/Repair

  • ICRF-193 | Topoisomerase II poison
    CAS:
    21416-88-6
    Catalog Number:
    10-5056
  • LD2 | PRMT9 inhibitor
    CAS:
    1134334-55-6
    Catalog Number:
    10-4872
    Activity:
    PRMT9 inhibitor
    Chemical Names:
    4-Chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole
    Molecular Weight:
    247.68
    Molecular Formula:
    C12H10ClN3O
    Solubility:
    Soluble in DMSO (at least 40 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Topotecan HCl | DNA topoisomerase I inhibitor
    CAS:
    119413-54-6
    Catalog Number:
    10-2479
  • AOH1996 | PCNA inhibitor
    CAS:
    2089314-64-5
    Catalog Number:
    10-4992
  • TH10785 | OGG1 activator
    CAS:
    1002801-51-5
    Catalog Number:
    10-5698
View All DNA Damage/Repair Products

Drug resistance

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Epigenetics

  • LD2 | PRMT9 inhibitor
    CAS:
    1134334-55-6
    Catalog Number:
    10-4872
    Activity:
    PRMT9 inhibitor
    Chemical Names:
    4-Chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole
    Molecular Weight:
    247.68
    Molecular Formula:
    C12H10ClN3O
    Solubility:
    Soluble in DMSO (at least 40 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • MS012 | Potent and selective GLP lysine methyltransferase inhibitor
    CAS:
    2089617-83-2
    Catalog Number:
    10-4875
    Activity:
    Potent and selective GLP lysine methyltransferase inhibitor
    Chemical Names:
    N2-Hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
    Molecular Weight:
    401.55
    Molecular Formula:
    C22H35N5O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • iPHF8 | Inhibitor of lysine demethylase PHF8
    CAS:
    N/A
    Catalog Number:
    10-4049
  • BRM014 | BRM/BRG1 ATPase inhibitor
    CAS:
    2270879-17-7
    Catalog Number:
    10-5244
  • WM-1119 | HAT KAT6A inhibitor
    CAS:
    2055397-28-7
    Catalog Number:
    10-4013
View All Epigenetics Products

Gene Regulation/Transcription

View All Gene Regulation/Transcription Products

Growth factors

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Immuno-oncology

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Kinases

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Metastasis

  • Decoyinine | Inhibitor of GMP synthase
    CAS:
    2004-04-8
    Catalog Number:
    10-5149
  • P053 | Protein phosphatase 5 inhibitor
    CAS:
    1022417-69-1
    Catalog Number:
    10-4060
  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Bosutinib | Dual Src/Abl kinase inhibitor
    CAS:
    380843-75-4
    Catalog Number:
    10-2122
    Activity:
    Dual Src/Abl kinase inhibitor
    Chemical Names:
    4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
    Alternate Name:
    SKI-606
    Molecular Weight:
    530.45
    Molecular Formula:
    C26H29Cl2N5O3
    Solubility:
    Soluble in DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Remodelin | Acetyltransferase NAT10 inhibitor
    CAS:
    949912-58-7
    Catalog Number:
    10-5085
    Activity:
    Acetyl-transferase NAT10 inhibitor
    Chemical Name:
    4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
    Molecular Weight:
    282.36
    Molecular Formula:
    C15H14N4S
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Metastasis Products

Other Cancer

View All Other Cancer Products

p53 & Other Tumor Suppressors

  • SR1078 | ROR agonist
    CAS:
    1246525-60-9
    Catalog Number:
    10-4066
  • Phenylhexyl isothiocyanate | Chemopreventive/HDAC inhibitor/p53 reactivator
    CAS:
    133920-06-6
    Catalog Number:
    10-5258
  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • Tenovin-1 | SIRT1/2 inhibitor
    CAS:
    380315-80-0
    Catalog Number:
    10-2982
    Activity:
    SIRT1/2 Inhibitor
    Chemical Names:
    N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
    Molecular Weight:
    369.48
    Molecular Formula:
    C20H23N3O2S
    Solubility:
    Soluble in DMSO (10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RITA | p53 Activator
    CAS:
    213261-59-7
    Catalog Number:
    10-3385
    Activity:
    p53 Activator
    Chemical Names:
    5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol;
    NSC 652287
    Molecular Weight:
    292.37
    Molecular Formula:
    C14H12O3S2
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All p53 & Other Tumor Suppressors Products

Programmed cell death

View All Programmed cell death Products

Stem Cells

  • LD2 | PRMT9 inhibitor
    CAS:
    1134334-55-6
    Catalog Number:
    10-4872
    Activity:
    PRMT9 inhibitor
    Chemical Names:
    4-Chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole
    Molecular Weight:
    247.68
    Molecular Formula:
    C12H10ClN3O
    Solubility:
    Soluble in DMSO (at least 40 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • MLS-544460 | Eya2 phosphatase inhibitor
    CAS:
    352336-36-8
    Catalog Number:
    10-5332
  • BIBR1532 | Telomerase inhibitor
    CAS:
    321674-73-1
    Catalog Number:
    10-3920
  • CDDO-Me | Nrf2 activator
    CAS:
    218600-53-4
    Catalog Number:
    10-5449
    Activity:
    Nrf2 activator
    Chemical Names:
    2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
    Alternate Name:
    Bardoxolone methyl; NSC-713200; RTA 402; TP-155
    Molecular Weight:
    505.70
    Molecular Formula:
    C32H43NO4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dodecyl-TPP | Mitochondria-targeted reagent
    CAS:
    15510-55-1
    Catalog Number:
    10-3781
    Activity:
    Mitochondria-targeted reagent
    Chemical Names:
    Dodecyltriphenylphosphonium bromide
    Molecular Weight:
    511.52
    Molecular Formula:
    C30H40BrP
    Solubility:
    Soluble in DMSO (50 mg/ml) or ethanol (25 mg/mL)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Stem Cells Products

Ubiquitin proteasome

  • SKPin C1 | Ubiquitin ligase E3 SCF-Skp2 inhibitor
    CAS:
    432001-69-9
    Catalog Number:
    10-1441
    Activity:
    Ubiquitin ligase E3 SCF-Skp2 inhibitor
    Chemical Names:
    2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl¬methyl)-2-thioxo-5-thiazolidinylidene]methyl]-phenoxy]acetic acid
    Molecular Weight:
    465.34
    Molecular Formula:
    C18H13BrN2O4S2
    Solubility:
    Soluble in DMSO (15 mg/ml with warming)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • E7820 | RBM39 molecular glue
    CAS:
    289483-69-8
    Catalog Number:
    10-3935
  • EN450 | NFkB1 molecular glue
    CAS:
    793719-01-4
    Catalog Number:
    10-3936
  • SJ6986 | GSPT1 molecular glue
    CAS:
    2765625-93-0
    Catalog Number:
    10-3933
  • Indisulam | RBM39 Molecular glue
    CAS:
    165668-41-7
    Catalog Number:
    10-3927
View All Ubiquitin proteasome Products

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Plymouth Meeting, PA USA
1-855-FOCUS21

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