Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

VIEW ALL Biochemical Targets

Mitochondria are organelles found in every cell and provide most of the energy for cellular functioning and survival. They also help regulate cellular metabolism, are involved in apoptosis, calcium signaling, cell cycle control, and cell growth and differentiation. Mitochondrial dysfunction has been implicated in metabolic disorders, neurodegenerative diseases, ischemia-related heart and brain injury, cancer, cardiovascular disease, and other disorders.

Respiratory Chain / Oxidative Phosphorylation

HQNO

Potent respiratory chain inhibitor – binds to mitochondrial cytochrome b.

N-Oleoylphenylalanine

N-Oleoylphenylalanine is an endogenous uncoupler of mitochondrial respiration

FCCP

FFCP is a potent uncoupler of mitochondrial respiration Membrane permeability

Membrane potential

Valinomycin

Selective K+ ionophore that causes a rapid loss of mitochondrial membrane potential

Tropodithietic acid

Tropodithietic acid displays cytotoxic effects acting via disruption of mitochondrial membrane potential

Nonactin

Nonactin abolishes mitochondrial membrane potential

ROS / Glutathione

Mitoquinone

Mitoquinone is a mitochondria-targeted antioxidant

Piperlongumine

Piperlongumine is a glutathione sponge that increases ROS levels

Membrane Permeability

Betulinic acid

Betulinic acid induces mitochondrial permeability transition pore opening

Decylubiquinone

Decylubiquinone inhibits the Ca2+ dependent mitochondrial permeability transition pore without inhibiting respiration

Mdivi

Mdivi is a selective inhibitor of Dnm1 GTPase that inhibits mitochondrial outer membrane permeabilization

Transporters and Carriers

MitoBloCK-6

Inhibits redox-regulated protein translation into mitochondria

Puromycin

Aminonucleoside antibiotic that inhibits protein transport in mitochondria

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