CANCER
Immunology
Stem Cells
Cell Death
Neurodegeneration
Cellular Stress
Inflammation
Proteasome
Diabetes
View All Physiological Processes & Diseases
Neurodegeneration is a progressive deterioration of neuronal structures and function that ultimately leads to cognitive disability, dementia, and/or motor defects depending on the affected area of the brain. Neurodegenerative disorders can be caused by genetic mutations, aggregation of misfolded proteins, accumulation of toxic intracellular proteins, organelle membrane damage, and mitochondrial dysfunction. Common disorders include multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
Alzheimer’s
PNU 282987
Potent and selective a7 nAChR agonist
N-Eicosanoyl serotonin
Natural product that prevents Aβ-induced impairments in a mouse model of Alzheimer’s
FPS-ZM1
FPS-ZM1 Is a high -affinity RAGE receptor antagonist
ABT-418
Neuronal nicotinic receptor agonist that improves cognition in Alzheimer’s patients
Parkinson’s
Terguride
Terguride is a partial dopamine D2 and serotonin 5HT2B/2C antagonist
Rasagiline mesylate
Potent and irreversible MAO-B inhibitor
MPEP HCl
MPEP is a potent mGlu5 receptor antagonist
Entacapone
Entacapone is a catechol O-methyltransferase inhibitor that increases the bioavailability of L-DOPA
Stem Cells
ISX9
Promotes neurogenesis by enhancing the proliferation and differentiation of neuroblasts
Neurodazine
Induces neurogenesis of non-pluripotent myoblasts
Neuropathiazol
Induces neuronal differentiation of multipotent hippocampal neural progenitor cells
Multiple Sclerosis
MDL29,951
MDL29,951 is a GPR17 activator
RIPA-56
RIP1 kinase inhibitor that blocked progression of multiple sclerosis in an immune-induced demyelination model
Benztropine mesylate
Centrally acting M1 muscarinic acetylcholine receptor antagonist that induces remyelination of neurons
FTY720 HCl
Clinically useful multiple sclerosis drug that is a sphingosine-1-phosphate receptor modulator
Amyotrophic lateral sclerosis
Pridopidine
Sigma-1 ligand that ameliorates the central features of ALS
Riluzole
Sodium channel blocker used in the treatment of ALS
P7C3
P7C3 delays disease progression in the G93A-SOD2 mutant mouse model of ALS
WHI-P131
WHI-P131 is a JAK3 inhibitor that increases survival in a mouse model of ALS
Neuroinflammation
Leonurine
Inhibits microglial activation via JNK and NFk-B pathways
Synaptamide
Endogenous GPR110 agonist that ameliorates LPS-induced neuroinflammation in a mouse model
C-DIM 12
C-DIM 12 activates the orphan receptor Nurr1 and displays strong neuroinflammatory inhibition
NEW PRODUCTS
BIOCHEMICAL TARGETS
PROCESSES AND DISEASES
CUSTOM SYNTHESIS
CHEMICAL LIBRARIES
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
United Kingdom
Tebu-bio UK & Ireland
Unit 7 - Flag Business Exchange
Vicarage Farm Road
Peterborough
Cambs PE1 5TX
England
Phone: +44 (0)1733 421880
Fax: +44 (0)1733 421882
www.tebu-bio.com
2B Scientific
Cherwell Innovation Centre
77 Heyford Park
Upper Heyford
OX25 5HD
UK
Phone: +44(0) 1869 238033
Fax: +44(0) 1869 238034
E-mail: info@2BScientific.com
sales@2BScientific.com
www.2BScientific.com
Germany
Tebu-bio GmbH
Berliner Str. 255
D-63067 Offenbach
Tel: (069) 801013-0
Fax: (069) 801013-20
www.tebu-bio.com
BIOZOL Diagnostica Vertrieb GmbH
Obere Hauptstrasse 10b
85386 Eching
Tel: +498937996666
E-mail: info@biozol.de
www.biozol.de
Biotrend Germany
Wilhelm-Mauser-Str. 41-43
50827 Köln
Tel: +49 221 9498320
Fax: +49 221 9498325
Email:Â info @biotrend.com
www.biotrend.com
Portugal
Tebu-bio Portugal
Quinta da Fonte
Rua dos Malhões
EdifÃcio D. Pedro I
2770-071 Paco D'Arcos
Phone: 21 000 82 48
Fax: 21 000 16 75
www.tebu-bio.com
Fax: (069) 801013-20
www.tebu-bio.com
Switzerland
LucernaChem Ag
Abendweg 18
CH-6006 Luzern
Switzerland
Phone: +41 (0)41 420 9636
Fax: +41 (0)41 420 9656
E-mail: lucerna-chem@lucerna-chem.ch
www.lucerna-chem.ch
Anawa
Unterdorfstrasse 21
CH-8602 Wangen
Switzerland
Phone: +41 (0)44 805 76 81
Fax: +41 (0)44 805 76 75
E-mail: contactus@anawa.ch
www.anawa.ch
Belgium
Tebu-bio
tebu-bio Belgium
Alexander Franckstraat 196
B-2530 Boechout
Phone: 03/ 454 00 66
Fax: 03/ 454 18 88
www.tebu-bio.com
Austria
Biomedica Medizinprodukte gmbH & Co KG
Divischgasse 4
1210 Vienna
Austria
Phone: +43 1 291 07 0
Fax: +43 1 290 14 29
Email: office@bmgrp.at
www.bmgrp.at
Biotrend Austria
Sternwartwatrasse 76
A-1180 Wien
Austria
Phone: +43 7201 15577
Fax: +43 7201 15580
Email:info@biotrend.com
www.biotrend.com
Bulgaria
Biomedica Bulgaria Ltd.
2E "Akad. Ivan E. Geshov" blvd.
Business center "Serdika" build. 2, floor 2, office 203
Sofia 1330
Bulgaria
Phone: +359 2 447 2833
Fax: +359 2 447 2831
Email: office@bmgrp.bg
www.bmgrp.bg
Czech Republic
Biomedica CS, s.r.o.
Sokolovska 100/94, Meteor B
186 00 Praha 8 - Karlin
Czech Republic
Phone: +420 2 839 33 605
Fax: +420 2 839 32 507
Email: office@bmgrp.cz
www.bmgrp.cz
Macedonia
Biomedica dijagnostika Ltd.
Ul. Ilindenska br. 103 lokal 2 and 3
1000 Skopje
Macedonia
Phone: +389 232 22 404
Fax: +389 232 22 404
Email: office@bmgrp.mk
www.bmgrp.mk
Romania
Biomedica Medizinprodukte Romania SRL
Strada Siriului nr. 42-46, Et.2, Sector 1
014354 Bucharest
Romania
Phone: +40 37 276 68 44
Fax: +40 21 232 22 04
Email: office@bmgrp.ro
www.bmgrp.ro
France
Tebu-bio France
39 Rue de Houdan - BP 15
78612 Le Perray-en-Yvelines Cedex
Phone: 01 30 46 39 00
Fax: 01 30 46 39 11
www.tebu-bio.com
CliniSciences France
74 Rue des Suisses
92000 Nanterre
Phone: +33 9 77 40 09 09
Fax: +33 9 77 40 10 11
info@clinisciences.com
www.clinisciences.com
Spain
Tebu-bio Spain
Gran Via de les Corts Catalanes, 583-5°
ES-08011 Barcelona
Phone: 93 306 34 10
Fax: 93 306 34 99
www.tebu-bio.com
Italy
DBA Italia
Via Umbria, 10
20090 Segrate (Milan)
Italy
Phone: +39 02 26922300
Fax: +39 02 26923535
E-mail: info@dbaitalia.it
www.dbaitalia.it
Tebu-bio Italy
Via Pretorio 4 - C.P. 70
I-20013 Magenta MI
Phone: 02 97 20 50 10
Fax: 02 97 29 50 77
Clinisciences Italy
Via Maremmana Inferiore 378
00012 Guidonia Montecelio (Roma)
Phone: +39 06 94 80 56 71
Fax: +39 06 94 80 00 21
Italia@clinisciences.com
www.clinisciences.com
Denmark
CAT Science Park
Universitetsparken 7
4000 Roskilde
Denmark
Phone: +45 46 74 02 54
Fax: +45 46 74 02 53
www.tebu-bio.com
CliniSciences Denmark
Herlev Hovedgade 195
2730 Herlev
Phone: +45 89 888 349
Fax: +45 89 884 064
danmark@clinisciences.com
www.clinisciences.com
Sweden
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Finland
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Netherlands
Tebu-bio Netherlands Â
Bevelandseweg 80
NL-1703 AX Heerhugowaard
Phone: 072-572 21 00
Fax: 072-572 21 33
www.tebu-bio.com
Bosnia-Herzegovina
Biomedica d.o.o
Dr. Silve Rizvanbegovic bb
71210 Ilidza, Sarajevo
Bosnia and Herzegovina
Phone: +387 33 262 725
Fax: 387 33 262 726
Email: office@bmgrp.ba
www.bmgrp.ba
Croatia
Biomedica Dijagnostika d.o.o.
Strojarska 20/X
10000 Zagreb
Croatia
Phone: +385 1 888 5727
Fax: +385 1 888 5728
Email: office@bmgrp.hr
www.bmgrp.hr
Hungary
Biomedica Hungaria Kft.
Ganz u. 16
1027 Budapest
Hungary
Phone: +361 225 38 50
Fax: +361 201 26 84
Email: office@bmgrp.hu
www.bmgrp.hu
Poland
Biomedica Poland sp. z.o.o.
Ul. Raszynska 13
05-500 Piaseczno
Poland
Phone: +48 22 737 5996
Fax: +48 22 737 5994
Email: office@bmgrp.pl
www.bmgrp.pl
Serbia
Biomedica MP d.o.o. Â
Lazara Mamuzica 26a
11186 Zemun
Serbia
Phone: +381 11 630 1882
Fax: +381 11 630 1883
Email: office@bmgrp.rs
www.bmgrp.rs
Slovenia
Biomedica M.B. d.o.o. Â
Slokanova 12
2000 Maribor
Slovenia
Phone: +386 2 471 63 01
Fax: +386 2 471 63 04
Email: office@bmgrp.si
www.bmgrp.si
Slovakia
Biomedica Slovakia s.r.o.
Drobneho 27
84101 Bratislava
Slovakia
Phone: +421 2 693 099 01
Fax: +421 2 693 099 08
Email: office@bmgrp.sk
www.bmgrp.sk
®Copyright 2021 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative