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Neurodegeneration is a progressive deterioration of neuronal structures and function that ultimately leads to cognitive disability, dementia, and/or motor defects depending on the affected area of the brain. Neurodegenerative disorders can be caused by genetic mutations, aggregation of misfolded proteins, accumulation of toxic intracellular proteins, organelle membrane damage, and mitochondrial dysfunction. Common disorders include multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

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Alzheimer’s

PNU 282987

Potent and selective a7 nAChR agonist

N-Eicosanoyl serotonin

Natural product that prevents Aβ-induced impairments in a mouse model of Alzheimer’s

FPS-ZM1

FPS-ZM1 Is a high -affinity RAGE receptor antagonist

ABT-418

Neuronal nicotinic receptor agonist that improves cognition in Alzheimer’s patients

Parkinson’s

Terguride

Terguride is a partial dopamine D2 and serotonin 5HT2B/2C antagonist

Rasagiline mesylate

Potent and irreversible MAO-B inhibitor

MPEP HCl

MPEP is a potent mGlu5 receptor antagonist

Entacapone

Entacapone is a catechol O-methyltransferase inhibitor that increases the bioavailability of L-DOPA

Stem Cells

ISX9

Promotes neurogenesis by enhancing the proliferation and differentiation of neuroblasts

Neurodazine

Induces neurogenesis of non-pluripotent myoblasts

Neuropathiazol

Induces neuronal differentiation of multipotent hippocampal neural progenitor cells

Multiple Sclerosis

MDL29,951

MDL29,951 is a GPR17 activator

RIPA-56

RIP1 kinase inhibitor that blocked progression of multiple sclerosis in an immune-induced demyelination model

Benztropine mesylate

Centrally acting M1 muscarinic acetylcholine receptor antagonist that induces remyelination of neurons

FTY720 HCl

Clinically useful multiple sclerosis drug that is a sphingosine-1-phosphate receptor modulator

Amyotrophic lateral sclerosis

Pridopidine

Sigma-1 ligand that ameliorates the central features of ALS

Riluzole

Sodium channel blocker used in the treatment of ALS

P7C3

P7C3 delays disease progression in the G93A-SOD2 mutant mouse model of ALS

WHI-P131

WHI-P131 is a JAK3 inhibitor that increases survival in a mouse model of ALS

Neuroinflammation

Leonurine

Inhibits microglial activation via JNK and NFk-B pathways

Synaptamide

Endogenous GPR110 agonist that ameliorates LPS-induced neuroinflammation in a mouse model

C-DIM 12

C-DIM 12 activates the orphan receptor Nurr1 and displays strong neuroinflammatory inhibition

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