Diabetes
Adipogenesis Adiponectin Aldose reductase AMPK DPP4 FFAR Glucose metabolism GPCRs GSK-3 Insulin PPAR Other Diabetes
Showing 1–12 of 81 results
-
Adipogenesis
20(S)-Hydroxycholesterol | Smoothened activator
20(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal...$40.00 – $90.00 Select options -
New Products
5-Thio-D-glucose | Glucose transport inhibitor
5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be ...$80.00 – $320.00 Select options -
Cardiovascular
6BIO | GSK-3 inhibitor
6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to m...$65.00 – $260.00 Select options -
cAMP
8-pCPT-2-O-Me-cAMP-AM | Epac activator
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1 Induces RAP1 activa...$148.00 Select options -
Adipogenesis
A-769662 | AMPK activator
A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and...$72.00 – $250.00 Select options -
Adiponectin
AdipoRon | Adiponectin agonist
AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively.1 Display...$50.00 – $200.00 Select options -
Bioactive Lipids
AH-7614 | GPR120 antagonist
AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citation...$45.00 – $180.00 Select options -
AMPK
AICAR | AMPK activator
AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal...$40.00 – $160.00 Select options -
Angiogenesis
Alsterpaullone | GSK-3ß inhibitor
Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM).1 Alsterp...$56.00 – $224.00 Select options -
Diabetes
Amlexanox | TBK1 inhibitor / Antidiabetic
Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosi...$40.00 – $100.00 Select options -
Antivirals
Andrographolide | Induces mitochondrial-mediated apoptosis
Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-ap...$34.00 – $136.00 Select options -
Alzheimers
AR-A 014418 | GSK-3 inhibitor
AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration...$50.00 – $200.00 Select options
