Pain

Pain is “an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage” according to the International Association for the Study of Pain. It may be acute or chronic in nature and is an important component of quality of life. Pain research involves multiple areas, including opioid and cannabinoid signaling, inflammation, nitric oxide, TRP and other ion channels, and many others.

Calcium channels

  • CBD3063 | Cav2.2 blocker
    CAS:
    1281060-70-5
    Catalog Number:
    10-4954
  • BAY-1797 | P2X4 antagonist
    CAS:
    2055602-83-8
    Catalog Number:
    10-3980
    Activity:
    P2X4 antagonist
    Chemical Names:
    N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
    Molecular Weight:
    416.88
    Molecular Formula:
    C20H17ClN2O4S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale brown solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • A-438079 HCl | P2X7 antagonist
    CAS:
    899431-18-6
    Catalog Number:
    10-4063
    Activity:
    P2X7 antagonist
    Chemical Names:
    3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
    Molecular Weight:
    342.61
    Molecular Formula:
    C13H9Cl2N5·HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • TTA-P2 | Potent and selective T-type calcium channel antagonist
    CAS:
    918430-49-6
    Catalog Number:
    10-3993
    Activity:
    Selective T-type calcium channel antagonist
    Chemical Names:
    (±)-3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
    Molecular Weight:
    431.37
    Molecular Formula:
    C21H29Cl2FN2O2
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    >97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Calcium channels Products

Cannabinoid

  • WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist
    CAS:
    131543-23-2
    Catalog Number:
    10-2002
    Activity:
    Cannabinoid CB1/CB2 agonist
    Chemical Name:
    (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
    Molecular Weight:
    522.62
    Molecular Formula:
    C27H26N2O3 CH3SO3H
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • AM-404 | Anandamide transport inhibitor
    CAS:
    198022-70-7
    Catalog Number:
    10-2008
    Activity:
    Anandamide transport inhibitor
    Chemical Name:
    N-(4-Hydroxyphenyl)arachidonamide
    Molecular Weight:
    395.58
    Molecular Formula:
    C26H37NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Compound is subject to oxidation, store under inert gas to protect from exposure to air. Solutions in DMSO or ethanol may be stored under nitrogen or argon at -20° for up to 3 months.
    Shipping Code:
    Blue Ice
  • Anandamide | Endogenous cannabinoid
    CAS:
    94421-68-8
    Catalog Number:
    10-2009
    Activity:
    Endogenous cannabinoid
    Alternate Names:
    Arachidonoylethanolamide; AEA
    Chemical Name:
    N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
    Molecular Weight:
    347.54
    Molecular Formula:
    C22H27NO2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml).
    Physical Properties:
    Colorless oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -80°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
    Shipping Code:
    Blue Ice
  • URB-597 | FAAH inhibitor
    CAS:
    546141-08-6
    Catalog Number:
    10-1301
    Activity:
    FAAH inhibitor
    Chemical Name:
    Cyclohexylcarbamic acid 3′-(aminocarbonyl)-[1,1′-biphenyl]-3-yl ester
    Molecular Weight:
    338.41
    Molecular Formula:
    C20H22N2O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Palmitoylethanolamide | GPR55 agonist
    CAS:
    544-31-0
    Catalog Number:
    10-1297
    Activity:
    GPR55 agonist
    Alternate Names:
    PEA
    Chemical Name:
    N-(2-Hydroxyethyl)palmitamide
    Molecular Weight:
    299.49
    Molecular Formula:
    C18H37NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Cannabinoid Products

COX

  • Rofecoxib | Selective COX-2 inhibitor
    CAS:
    162011-90-7
    Catalog Number:
    10-2440
    Activity:
    Selective COX-2 inhibitor
    Alternate Names:
    MK-966
    Chemical Name:
    4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
    Molecular Weight:
    314.36
    Molecular Formula:
    C17H14O4S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Sulindac Sulfide | NFkappaB inhibitor
    CAS:
    49627-27-2
    Catalog Number:
    10-2156
    Activity:
    NFkappaB inhibitor
    Chemical Name:
    (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
    Molecular Weight:
    340.42
    Molecular Formula:
    C20H17FO2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Celecoxib | COX II inhibitor
    CAS:
    169590-42-5
    Catalog Number:
    10-2124
    Activity:
    COX II inhibitor
    Alternate Names:
    SC-58635
    Chemical Name:
    4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
    Molecular Weight:
    381.38
    Molecular Formula:
    C17H14F3N3O2S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Oxaprozin | NFkB inhibitor
    CAS:
    21256-18-8
    Catalog Number:
    10-1128
    Activity:
    NFκB inhibitor
    Chemical Name:
    4,5-Diphenyl-2-oxazolepropanoic acid
    Molecular Weight:
    293.32
    Molecular Formula:
    C18H15NO3
    Solubility:
    Soluble in DMSO
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All COX Products

GABA

  • Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor
    CAS:
    145821-59-6
    Catalog Number:
    10-4384
    Activity:
    GABA transporter 1 (GAT1) inhibitor
    Chemical Name:
    (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
    Alternate Name:
    NO-328
    Molecular Weight:
    412.00
    Molecular Formula:
    C20H25NO2S2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All GABA Products

Nitric oxide

  • TRIM | Nitric oxide synthase inhibitor
    CAS:
    25371-96-4
    Catalog Number:
    10-2699
    Activity:
    Nitric oxide synthase inhibitor
    Chemical Name:
    1-(2-Trifluoromethylphenyl)imidazole
    Molecular Weight:
    212.18
    Molecular Formula:
    C107F3N2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Nitric oxide Products

Other Pain

View All Other Pain Products

Prostanoid receptors

  • Grapiprant | EP4 Receptor antagonist
    CAS:
    415903-37-6
    Catalog Number:
    10-4006
    Activity:
    EP4 Receptor antagonist
    Chemical Name:
    1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
    Alternate Names:
    CJ-023423; ARY-007
    Molecular Weight:
    491.61
    Molecular Formula:
    C26H29N5O3S
    Solubility:
    Soluble in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • SC-51089 | Prostaglandin E2 (EP1) antagonist
    CAS:
    146033-02-5
    Catalog Number:
    10-1135
    Activity:
    PGE2 (EP1 receptor) antagonist
    Chemical Names:
    8-Chlorodibenz(Z)[b,f]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
    Molecular Weight:
    459.34
    Molecular Formula:
    C22H19ClN4O3·HCl
    Solubility:
    Soluble in DMSO (25 mg/ml) or water (25 mg/mL)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Prostanoid receptors Products

Sodium channels

  • ICA-121431 | Selective Sodium channel blocker
    CAS:
    313254-51-2
    Catalog Number:
    10-4085
    Activity:
    Selective Nav1.1/1.3 inhibitor
    Chemical Names:
    2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
    Molecular Weight:
    449.54
    Molecular Formula:
    C23H19N3O3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to beige solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BAY-1797 | P2X4 antagonist
    CAS:
    2055602-83-8
    Catalog Number:
    10-3980
    Activity:
    P2X4 antagonist
    Chemical Names:
    N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
    Molecular Weight:
    416.88
    Molecular Formula:
    C20H17ClN2O4S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale brown solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • A-438079 HCl | P2X7 antagonist
    CAS:
    899431-18-6
    Catalog Number:
    10-4063
    Activity:
    P2X7 antagonist
    Chemical Names:
    3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
    Molecular Weight:
    342.61
    Molecular Formula:
    C13H9Cl2N5·HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • PF-05089771 | Selective Nav1.7 inhibitor
    CAS:
    1235403-62-9
    Catalog Number:
    10-3990
    Activity:
    Selective Nav1.7 channel blocker
    Chemical Name:
    4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
    Alternate Name:
    PF771
    Molecular Weight:
    500.34
    Molecular Formula:
    C18H12Cl2FN5O3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • A-803467 | NaV1.8 blocker
    CAS:
    944261-79-4
    Catalog Number:
    10-1066
    Activity:
    NaV1.8 blocker
    Chemical Name:
    5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
    Molecular Weight:
    357.8
    Molecular Formula:
    C19H16ClNO4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Sodium channels Products

TRP channels

  • Arvanil | TRPV1 channel activator
    CAS:
    128007-31-8
    Catalog Number:
    10-2741
  • PBMC·HCl | TRPM8 blocker
    CAS:
    1352138-54-5 (free base)
    Catalog Number:
    10-5707
    Activity:
    TRPM8 blocker
    Chemical Name:
    (S)-1-Phenylethyl(2-aminoethyl)(4-(benzyloxy)-3-methoxybenzyl)carbamate hydrochloride
    Molecular Weight:
    471.00
    Molecular Formula:
    C26H30N2O4·HCl
    Solubility:
    Soluble in DMSO (up to 30 mg/ml); water (10 mg/ml).
    Physical Properties:
    Off-white to pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Resiniferatoxin | TRPV1 activator
    CAS:
    57444-62-9
    Catalog Number:
    10-2103
  • Icilin | TRPM8 activator
    CAS:
    36945-98-9
    Catalog Number:
    10-4380
    Activity:
    TRPM8 activator
    Alternate Names:
    AG 3-5
    Chemical Name:
    3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one
    Molecular Weight:
    311.29
    Molecular Formula:
    C16H13N3O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml),
    Physical Properties:
    Yellow solid
    Purity:
    >98% by TLC
    NMR (conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • HC-067047 | TRPV4 blocker
    CAS:
    883031-03-6
    Catalog Number:
    10-1480
    Activity:
    TRPV4 blocker
    Chemical Name:
    2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
    Molecular Weight:
    471.51
    Molecular Formula:
    C26H28F3N3O2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All TRP channels Products

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