BiochemicalTargets

Transcription factors

Transcription factors are proteins that control the transcription of genetic information from DNA to messenger RNA by binding to various DNA sequences. There are over 1500 factors in the human genome that control cell division, growth, and death as well as many other functions. Focus Biomolecules offers many modulators of transcription factors such as PPAR, AhR, nuclear receptors, p53, TCF/β- catenin, NF-κB, and many more.

AP-1

  • Tanshinone IIA | AP-1 transcription factor inhibitor
    CAS:
    568-72-9
    Catalog Number:
    10-2186
    Activity:
    AP-1 transcription factor inhibitor
    Chemical Name:
    1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione
    Molecular Weight:
    294.35
    Molecular Formula:
    C19H18O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Andrographolide | Induces mitochondrial-mediated apoptosis
    CAS:
    5508-58-7
    Catalog Number:
    10-1173
    Activity:
    Induces mitochondrial-mediated apoptosis
    Molecular Weight:
    350.45
    Molecular Formula:
    C20H30O6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All AP-1 Products

Aryl hydrocarbon receptor

  • Laquinimod | Immunomodulator
    CAS:
    248281-84-7
    Catalog Number:
    10-4971
    Activity:
    Immunomodulator
    Chemical Names:
    5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
    Alternate Name:
    ABR-215062
    Molecular Weight:
    356.81
    Molecular Formula:
    C19H17ClN2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • CH-223191 | Arylhydrocarbon receptor antagonist
    CAS:
    301326-22-7
    Catalog Number:
    10-3089
    Activity:
    Arylhydrocarbon receptor antagonist
    Chemical Name:
    1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
    Molecular Weight:
    333.39
    Molecular Formula:
    C19H19N5O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Cinnabarinic acid | Endogenous AhR ligand
    CAS:
    606-59-7
    Catalog Number:
    10-2883
    Activity:
    Endogenous AhR ligand
    Chemical Name:
    2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
    Alternate Names:
    Cinnabaric acid
    Molecular Weight:
    300.22
    Molecular Formula:
    C14H8N2O6
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • DiMNF | AhR modulator (SAhRM)
    CAS:
    14756-24-2
    Catalog Number:
    10-1557
    Activity:
    AhR modulator (SAhRM)
    Chemical Name:
    2-(3,2-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
    Alternate Names:
    3’,4’-Dimethoxy-α-naphthoflavone
    Molecular Weight:
    332.45
    Molecular Formula:
    C21H16O4
    Solubility:
    Soluble in DMSO (up to 1.5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SR1 | Maintains stem cells in pluripotent state
    CAS:
    1227633-49-9
    Catalog Number:
    10-4508
    Activity:
    Maintains stem cells in pluripotent state
    Molecular Weight:
    466.00
    Molecular Formula:
    C24H23N5OS·HCl
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Aryl hydrocarbon receptor Products

CREB

  • JQ1 (+) | BET Bromodomain inhibitor
    CAS:
    1268524-70-4
    Catalog Number:
    10-1584
    Activity:
    BET Bromodomain inhibitor
    Chemical Name:
    (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
    Molecular Weight:
    456.99
    Molecular Formula:
    C23H25ClN4O2S
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All CREB Products

HIF

  • Roxadustat | Prolyl hydroxylase domain inhibitor / HIF stabilizer
    CAS:
    808118-40-3
    Catalog Number:
    10-4468
    Activity:
    Prolyl hydroxylase domain inhibitor / HIF stabilizer
    Chemical Name:
    2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
    Alternate Name:
    FG-4592
    Molecular Weight:
    352.35
    Molecular Formula:
    C19H16N2O5
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white or white solid
    Purity:
    99% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • YC-1 | Soluble guanylyl cyclase activator
    CAS:
    170632-47-0
    Catalog Number:
    10-1581
    Activity:
    Soluble guanylyl cyclase activator
    Chemical Name:
    3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
    Alternate Name:
    Lificiguat
    Molecular Weight:
    304.34
    Molecular Formula:
    C19H16N2O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Pink solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor
    CAS:
    1227158-85-1
    Catalog Number:
    10-4910
    Activity:
    HIF-1 / Mitochondrial complex I inhibitor
    Chemical Name:
    5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
    Molecular Weight:
    525.54
    Molecular Formula:
    C26H26F3N7O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • KC7F2 | HIF-1α inhibitor
    CAS:
    927822-86-4
    Catalog Number:
    10-4714
    Activity:
    HIF-1alpha inhibitor
    Chemical Name:
    N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
    Molecular Weight:
    570.38
    Molecular Formula:
    C16H16Cl4N2O4S4
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • HIF-2α-I2 | HIF-2α antagonist
    CAS:
    1422955-31-4
    Catalog Number:
    10-1508
    Activity:
    Hif-2α antagonist
    Chemical Name:
    N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
    Alternate Names:
    TC-S 7009
    Molecular Weight:
    308.65
    Molecular Formula:
    C12H6ClFN4O3
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 35 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All HIF Products

Myc

  • 10074-G5 | c-Myc inhibitor
    CAS:
    413611-93-5
    Catalog Number:
    10-5627
    Activity:
    c-Myc inhibitor
    Chemical Names:
    7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
    Molecular Weight:
    332.32
    Molecular Formula:
    C18H12N4O3
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • WP1066 | JAK2/STAT3 inhibitor
    CAS:
    857064-38-1
    Catalog Number:
    10-4831
    Activity:
    JAK2/STAT3 inhibitor
    Chemical Name:
    (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
    Molecular Weight:
    356.22
    Molecular Formula:
    C18H14BrN3O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • THZ1 | Potent and selective CDK7 inhibitor
    CAS:
    1604810-83-4
    Catalog Number:
    10-4120
    Activity:
    Potent and selective CDK7 inhibitor
    Chemical Name:
    (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
    Molecular Weight:
    566.05
    Molecular Formula:
    C31H28ClN7O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Purvalanol A | CDK inhibitor
    CAS:
    212844-53-6
    Catalog Number:
    10-2868
    Activity:
    CDK Inhibitor
    Chemical Name:
    (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
    Alternate Names:
    NG-60
    Molecular Weight:
    388.89
    Molecular Formula:
    C19H25ClN6O
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    Pale green solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc
    CAS:
    1028486-01-2
    Catalog Number:
    10-4124
    Activity:
    Potent and selective inhibitor of Aurora A / Destabilizes Myc
    Chemical Name:
    4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
    Alternate Names:
    MLN8237
    Molecular Weight:
    518.92
    Molecular Formula:
    C27H20ClFN4O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Myc Products

NF-kB

View All NF-kB Products

Nrf2

  • Lipoic acid | Endogenous antioxidant and cofactor
    CAS:
    1077-28-7
    Catalog Number:
    10-5094
  • Probucol | Antioxidant hypercholesterolemic agent
    CAS:
    23288-49-5
    Catalog Number:
    10-2679
  • CBR-470-1 | NRF2 signaling activator
    CAS:
    2416095-06-0
    Catalog Number:
    10-4680
  • CDDO-Me | Nrf2 activator
    CAS:
    218600-53-4
    Catalog Number:
    10-5449
    Activity:
    Nrf2 activator
    Chemical Names:
    2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
    Alternate Name:
    Bardoxolone methyl; NSC-713200; RTA 402; TP-155
    Molecular Weight:
    505.70
    Molecular Formula:
    C32H43NO4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Sulfopin | Pin1 inhibitor
    CAS:
    2451481-08-4
    Catalog Number:
    10-4450
    Activity:
    Pin1 inhibitor
    Chemical Names:
    2-Chloro-N-(2,2-dimethylpropyl)-N-(1,1-dioxothiolan-3-yl)acetamide
    Molecular Weight:
    281.80
    Molecular Formula:
    C11H20ClNO3S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Nrf2 Products

Other Transcription factors

  • Verrucarin A | Steroid receptor coactivator-3 inhibitor
    CAS:
    3148-09-2
    Catalog Number:
    10-3564
  • PY-60 | YAP Activator
    CAS:
    2765218-56-0
    Catalog Number:
    10-3924
  • Ceapin-A7 | ATF6α/UPR inhibitor
    CAS:
    2323027-38-7
    Catalog Number:
    10-3974
    Activity:
    ATF6α/UPR inhibitor
    Chemical Names:
    N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
    Molecular Weight:
    470.33
    Molecular Formula:
    C20H12F6N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • WP631 | SP-1 activated transcription inhibitor
    CAS:

    Not available

    Catalog Number:
    10-3497
    Activity:
    SP-1 activated transcription inhibitor
    Chemical Names:

    4-Methylbenzyl-N-bis[daunomycin], mesylate salt

    Molecular Weight:
    1349.38
    Molecular Formula:
    C62H64N2O20 ∙ 2CH3SO3H
    Solubility:
    Soluble in DMSO (up to 5 mg/ml)
    Physical Properties:
    Red solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des,)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AA147 | ATF6 activator
    CAS:
    393121-74-9
    Catalog Number:
    10-3973
    Activity:
    Activator of ER stress sensing protein ATF6
    Chemical Names:
    N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide; Compound 147
    Molecular Weight:
    255.32
    Molecular Formula:
    C16H17NO2
    Solubility:
    Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
    Physical Properties:
    Beige to pale orange solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Other Transcription factors Products

p53

View All p53 Products

STAT

  • WP1066 | JAK2/STAT3 inhibitor
    CAS:
    857064-38-1
    Catalog Number:
    10-4831
    Activity:
    JAK2/STAT3 inhibitor
    Chemical Name:
    (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
    Molecular Weight:
    356.22
    Molecular Formula:
    C18H14BrN3O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
    CAS:
    83280-65-3
    Catalog Number:
    10-3442
    Activity:
    STAT3 inhibitor / Cancer cell stemness inhibitor
    Chemical Name:
    2-Acetylnsphtho[2,3-b]furan-4,9-dione
    Alternate Names:
    BBI608
    Molecular Weight:
    240.21
    Molecular Formula:
    C14H8O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant
    CAS:
    21802-37-9
    Catalog Number:
    10-2897
    Activity:
    Blocks STAT1 signaling / Immunosuppressant
    Chemical Name:
    (2Z)-4-Methoxy-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
    Molecular Weight:
    229.23
    Molecular Formula:
    C12H11N3O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Niclosamide | STAT3 signaling inhibitor
    CAS:
    50-65-7
    Catalog Number:
    10-2474
    Activity:
    STAT3 signaling inhibitor
    Chemical Name:
    5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
    Molecular Weight:
    327.13
    Molecular Formula:
    C13H8Cl2N2O4
    Solubility:
    Soluble in DMSO (up to 3 mg/ml), or in Ethanol (up to 6 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Stattic | STAT3 inhibitor
    CAS:
    19983-44-9
    Catalog Number:
    10-2524
    Activity:
    STAT3 inhibitor
    Chemical Name:
    6-Nitrobenzo[b]thiophene 1,1-dioxide
    Molecular Weight:
    211.2
    Molecular Formula:
    C8H5NO4S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    Light yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All STAT Products

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