BiochemicalTargets

Gene regulation

Gene regulation is a broad topic that includes epigenetics, transcription, translation, post-translational modification, protein degradation, and all possible steps in between that affect DNA, RNA, and proteins. Focus Biomolecules offers modulators for each of these categories.

CRISPR

  • Trifluorothymidine | Proapoptotic antiproliferative agent
    CAS:
    70-00-8
    Catalog Number:
    10-1283
    Activity:
    Thymidylate synthase inhibitor / Anti-cancer agent
    Chemical Name:
    2’-Deoxy-5-trifluoromethyluridine
    Alternate Names:
    α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFT
    Molecular Weight:
    296.20
    Molecular Formula:
    C10H11F3N2O5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All CRISPR Products

DNA Polymerase

  • Fludarabine | DNA biosynthesis inhibitor
    CAS:
    21679-14-1
    Catalog Number:
    10-5047
    Activity:
    DNA synthesis inhibitor
    Chemical Names:
    9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218
    Molecular Weight:
    285.23
    Molecular Formula:
    C10H12FN5O4
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 7-Aminoactinomycin D | Fluorescent DNA Probe
    CAS:
    7240-37-1
    Catalog Number:
    10-2053
    Activity:
    Fluorescent DNA probe
    Molecular Weight:
    1270.42
    Molecular Formula:
    C62H87N13O16
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Purple solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions should be made fresh daily.
    Shipping Code:
    RT
  • Gemcitabine HCl | DNA polymerase inhibitor
    CAS:
    122111-03-9
    Catalog Number:
    10-2140
    Activity:
    DNA polymerase inhibitor
    Alternate Names:
    dFdC
    Chemical Name:
    2′-Deoxy-2′,2′-difluorocytidine hydrochloride
    Molecular Weight:
    299.66
    Molecular Formula:
    C9H11F2N3O4 HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Aphidicolin | DNA polymerase inhibitor
    CAS:
    38966-21-1
    Catalog Number:
    10-2058
    Activity:
    DNA polymerase inhibitor
    Chemical Name:
    (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
    Molecular Weight:
    338.48
    Molecular Formula:
    C20H34O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All DNA Polymerase Products

DNA Topoisomerase

  • Ciprofloxacin HCl | Fluoroquinoline antibiotic
    CAS:
    86393-32-0
    Catalog Number:
    10-3917
    Activity:
    Fluoroquinoline antibiotic
    Chemical Names:
    1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinolin-3-carboxylic acid hydrochloride hydrate
    Molecular Weight:
    385.83
    Molecular Formula:
    C17H18FN3O3·HCl·H2O
    Solubility:
    Soluble in water (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Topotecan HCl | DNA topoisomerase I inhibitor
    CAS:
    119413-54-6
    Catalog Number:
    10-2479
  • ß-Lapachone | Topoisomerase-1 inhibitor
    CAS:
    4707-32-8
    Catalog Number:
    10-2386
    Activity:
    Topoisomerase I inhibitor
    Chemical Name:
    3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
    Alternate Name:
    NSC-26326
    Molecular Weight:
    242.27
    Molecular Formula:
    C15H14O3
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • SN-38 | DNA topoisomerase I inhibitor
    CAS:
    86639-52-3
    Catalog Number:
    10-2425
    Activity:
    DNA topoisomerase I inhibitor
    Chemical Name:
    7-Ethyl-10-hydroxycamptothecin
    Molecular Weight:
    392.41
    Molecular Formula:
    C22H20N2O5
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Gemcitabine HCl | DNA polymerase inhibitor
    CAS:
    122111-03-9
    Catalog Number:
    10-2140
    Activity:
    DNA polymerase inhibitor
    Alternate Names:
    dFdC
    Chemical Name:
    2′-Deoxy-2′,2′-difluorocytidine hydrochloride
    Molecular Weight:
    299.66
    Molecular Formula:
    C9H11F2N3O4 HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All DNA Topoisomerase Products

eIF2a

  • ISRIB | Integrated stress response inhibitor
    CAS:
    159403-47-8
    Catalog Number:
    10-1539
    Activity:
    Integrated stress response inhibitor
    Chemical Name:
    N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
    Alternate Names:
    trans-ISRIB
    Molecular Weight:
    451.34
    Molecular Formula:
    C22H24Cl2N2O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Salubrinal | eIF2α Phosphatase inhibitor
    CAS:
    405060-95-9
    Catalog Number:
    10-4517
    Activity:
    eIF2α Phosphatase inhibitor
    Chemical Name:
    3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
    Molecular Weight:
    479.81
    Molecular Formula:
    C21H17Cl3N4OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml),
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All eIF2a Products

Nuclear Receptors

  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    CAS:
    178946-89-9
    Catalog Number:
    10-3280
    Activity:
    Nurr1 activator; NFkB inhibitor
    Chemical Name:
    3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
    Molecular Weight:
    356.85
    Molecular Formula:
    C23H17ClN2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Nuclear Receptors Products

Other Gene Regulation

  • HC-258 | Covalent TEAD inhibitor
    CAS:
    N/A
    Catalog Number:
    10-3931
  • Streptonigrin | Induces heterochromatin formation
    CAS:
    3930-19-6
    Catalog Number:
    10-3484
    Activity:
    Induces heterochromatin formation
    Source:
    Fermenation product from Streptomyces flocculus
    Alternate Names:
    Bruneomycin; NSC-45383
    Molecular Weight:
    506.47
    Molecular Formula:
    C25H22N4O8
    Solubility:
    Soluble in DMSO
    Physical Properties:
    Black solid
    Purity:
    >95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Fludarabine | DNA biosynthesis inhibitor
    CAS:
    21679-14-1
    Catalog Number:
    10-5047
    Activity:
    DNA synthesis inhibitor
    Chemical Names:
    9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218
    Molecular Weight:
    285.23
    Molecular Formula:
    C10H12FN5O4
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Chromomycin A3 | DNA Stain
    CAS:
    7059-24-7
    Catalog Number:
    10-2064
    Activity:
    DNA stain
    Chemical Names:
    Aburamycin B; CMA3; NSC-58514
    Molecular Weight:
    1183.25
    Molecular Formula:
    C57H82O26
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • JTE-607 | mRNA processing inhibitor
    CAS:
    188791-09-5
    Catalog Number:
    10-4842
    Activity:
    mRNA processing inhibitor
    Chemical Name:
    Ethyl (2S)-2-[[3,5-Dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate dihydrochloride
    Molecular Weight:
    597.36
    Molecular Formula:
    C25H31Cl2N3O5 • 2HCl
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Off-white to pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Other Gene Regulation Products

PARP

  • Rucaparib phosphate | PARP1 inhibitor
    CAS:
    459868-92-9
    Catalog Number:
    10-3321
    Activity:
    PARP1 inhibitor
    Chemical Name:
    8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
    Alternate Name:
    AG-14699; PF01367338
    Molecular Weight:
    421.36
    Molecular Formula:
    C19H18FN3O • H3PO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Olaparib | PARP1 inhibitor
    CAS:
    763113-22-0
    Catalog Number:
    10-2154
    Activity:
    PARP1 inhibitor
    Chemical Name:
    4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one
    Alternate Names:
    AZD-2281; KU-59436
    Molecular Weight:
    434.47
    Molecular Formula:
    C24H23FN4O3
    Solubility:
    Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • PJ-34 HCl | PARP1/2 inhibitor
    CAS:
    344458-15-7
    Catalog Number:
    10-2395
    Activity:
    PARP1,2 inhibitor
    Chemical Name:
    N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
    Molecular Weight:
    331.81
    Molecular Formula:
    C17H17N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Water (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ME-0328 | PARP3 inhibitor
    CAS:
    1445251-22-8
    Catalog Number:
    10-1484
    Activity:
    PARP3 inhibitor
    Chemical Name:
    3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
    Molecular Weight:
    321.38
    Molecular Formula:
    C19H19N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 3-Aminobenzamide | PARP inhibitor
    CAS:
    3544-24-9
    Catalog Number:
    10-1239
    Activity:
    PARP inhibitor
    Alternate Names:
    3-AB
    Molecular Weight:
    136.15
    Molecular Formula:
    C7H8N2O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 4 mg/ml).
    Physical Properties:
    White to tan solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All PARP Products

Protein Synthesis

  • eFT508 | Potent MNK1/2 inhibitor
    CAS:
    1849590-01-7
    Catalog Number:
    10-4081
  • Halofuginone HBr | Prolyl-tRNA synthetase inhibitor
    CAS:
    64924-67-0
    Catalog Number:
    10-2381
  • Homoharringtonine | Protein synthesis inhibitor
    CAS:
    26833-87-4
    Catalog Number:
    10-3033
    Activity:
    Protein synthesis inhibitor
    Chemical Names:
    Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
    Alternate Name:
    HHT; NSC141633; Omacetaxine mepesuccinate
    Molecular Weight:
    545.63
    Molecular Formula:
    C29H39NO9
    Solubility:
    Soluble in DMSO (75 mg/ml)
    Physical Properties:
    Pale yellow to off-white solid
    Purity:
    >95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
    CAS:
    2188-68-3
    Catalog Number:
    10-2608
    Activity:
    Protein synthesis inhibitor/SCAP degrader
    Chemical Names:
    Galanthidine; Amarylline; Narcissine
    Molecular Weight:
    323.77
    Molecular Formula:
    C16H17NO4·HCl
    Solubility:
    Soluble in water (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Emetine hydrochloride | Protein synthesis inhibitor
    CAS:
    316-42-7
    Catalog Number:
    10-3001
    Activity:
    Protein synthesis inhibitor
    Chemical Names:
    (2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride hydrate
    Molecular Weight:
    553.56
    Molecular Formula:
    C29H40N2O4·2HCl·XH2O
    Solubility:
    Soluble in Water (100 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Protein Synthesis Products

RNA Polymerase

View All RNA Polymerase Products

Telomerase

  • Cycloastragenol | Telomerase activator/Senolytic agent
    CAS:
    84605-18-5
    Catalog Number:
    10-3715
  • BIBR1532 | Telomerase inhibitor
    CAS:
    321674-73-1
    Catalog Number:
    10-3920
  • Helenalin | NFkB inhibitor
    CAS:
    6754-13-8
    Catalog Number:
    10-2783
    Activity:
    NFκB inhibitor
    Chemical Name:
    Natural sesquiterpenoid from Arnica species
    Molecular Weight:
    262.31
    Molecular Formula:
    C15H18O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Hypericin | Protein kinase C inhibitor
    CAS:
    548-04-9
    Catalog Number:
    10-2077
    Activity:
    Protein kinase C inhibitor
    Chemical Name:
    1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
    Molecular Weight:
    504.45
    Molecular Formula:
    C30H16O8
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Brown solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Telomerase Products

Transcription

View All Transcription Products

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Menu
Menu
Menu
Menu
VIEW DISTRIBUTORS LIST
Facebook Twitter Linkedin
Menu
Menu

Website Created by Advanta Advertising LLC.