DNA Damage/Repair

The dysregulation of the balance of DNA damage and repair leads to genomic mutation and is primary to tumor development and progression. It can also be involved in neurodegeneration and inflammation. The balance can be perturbed by mutagens, radiation, inherited mutations, inflammation, and cell cycle disruption. Many small molecule reagents are available that can either cause DNA damage or modulate the DNA repair response.

Alkylation

  • 2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    CAS:
    10356-76-0
    Catalog Number:
    10-2685
    Activity:
    Irreversible DNA methyl transferase inhibitor
    Alternate Names:
    FCDR; NSC-48006; FdCyd
    Chemical Name:
    5-Fluoro-2’deoxycytidine
    Molecular Weight:
    245.21
    Molecular Formula:
    C9H12FN3O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Mitomycin C | DNA crosslinking and damaging agent
    CAS:
    50-07-7
    Catalog Number:
    10-1170
    Activity:
    DNA crosslinking and damaging agent
    Chemical Name:
    Natural fermentation product from Streptomyces sp.
    Molecular Weight:
    334.33
    Molecular Formula:
    C15H18N4O5
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Water (up to 1 mg/ml).
    Physical Properties:
    Blue-violet solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Storing aqueous solutions is not recommended.
    Shipping Code:
    RT
View All Alkylation Products

ATM / ATR

  • VE-821 | Potent and selective ATR inhibitor
    CAS:
    1232410-49-9
    Catalog Number:
    10-5589
    Activity:
    ATR inhibitor
    Chemical Names:
    3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
    Molecular Weight:
    368.41
    Molecular Formula:
    C18H16N4O3S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • AZ20 | ATR kinase inhibitor
    CAS:
    1233339-22-4
    Catalog Number:
    10-4675
    Activity:
    ATR kinase inhibitor
    Chemical Name:
    4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole
    Molecular Weight:
    412.51
    Molecular Formula:
    C21H24N4O3S
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • KU-55933 | ATM Kinase Inhibitor
    CAS:
    587871-26-9
    Catalog Number:
    10-1518
    Activity:
    ATM Kinase Inhibitor
    Chemical Name:
    2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
    Molecular Weight:
    395.5
    Molecular Formula:
    C21H17NO3S2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All ATM / ATR Products

Cell Cycle Checkpoints

  • Adavosertib | Wee1 kinase inhibitor
    CAS:
    955365-80-7
    Catalog Number:
    10-4823
    Activity:
    Wee1 kinase inhibitor
    Chemical Names:
    1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
    Alternate Name:
    MK-1775; AZD1775
    Molecular Weight:
    500.61
    Molecular Formula:
    C27H32N8O2
    Solubility:
    Soluble in DMSO (70 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AZD7762 | Checkpoint kinase 1/2 inhibitor
    CAS:
    860352-01-8 (free base)
    Catalog Number:
    10-4771
    Activity:
    Checkpoint kinase 1/2 inhibitor
    Chemical Name:
    3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochloride
    Molecular Weight:
    398.88
    Molecular Formula:
    C17H19FN4O2S • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Yellow or brown solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • LY2603618 | Potent and selective Chk1 inhibitor
    CAS:
    911222-45-2
    Catalog Number:
    10-4123
    Activity:
    Potent and selective Chk1 inhibitor
    Chemical Name:
    N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)urea
    Alternate Names:
    Rabusertib
    Molecular Weight:
    436.30
    Molecular Formula:
    C18H22BrN5O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Nocodazole | Microtubule inhibitor
    CAS:
    31430-18-9
    Catalog Number:
    10-2387
    Activity:
    Microtubule inhibitor/CRISPR enhancer
    Alternate Names:
    R-17934
    Chemical Name:
    Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
    Molecular Weight:
    301.32
    Molecular Formula:
    C14H11N3O3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Mirin | Mre11-Rad50-Nbs1 inhibitor
    CAS:
    299953-00-7
    Catalog Number:
    10-1069
    Activity:
    Mre11-Rad50-Nbs1 inhibitor
    Chemical Name:
    5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
    Molecular Weight:
    220.25
    Molecular Formula:
    C10H8N2O2S
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cell Cycle Checkpoints Products

DNA Repair

  • SU0268 | OGG1 inhibitor
    CAS:
    2210228-45-6
    Catalog Number:
    10-4700
    Activity:
    OGG1 Inhibitor
    Chemical Names:
    3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
    Molecular Weight:
    475.56
    Molecular Formula:
    C26H25N3O4S
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • LNT 1 | FEN1 Inhibitor
    CAS:
    824983-91-7
    Catalog Number:
    10-4036
    Activity:
    FEN1 inhibitor
    Chemical Names:
    1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione; FEN1-IN-1
    Molecular Weight:
    332.33
    Molecular Formula:
    C15H12N2O5S
    Solubility:
    Soluble in DMSO (15 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RK-33 | DDX3 inhibitor
    CAS:
    1070773-09-9
    Catalog Number:
    10-4839
    Activity:
    DDX3 inhibitor
    Chemical Name:
    3,7-Bis(4-methoxybenzyl)-3,7-dihydro-1,3,4,6,7,9-hexaza-2H-cyclopenta[e]azulene-2-one
    Molecular Weight:
    428.44
    Molecular Formula:
    C23H20N6O3
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • IMP-1700 | Bacterial DNA repair inhibitor
    CAS:
    1458674-25-3
    Catalog Number:
    10-3950
    Activity:
    Bacterial DNA repair inhibitor
    Chemical Name:
    1-Cyclopropyl-6-fluoro-4-oxo-7-(4-(4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
    Molecular Weight:
    534.53
    Molecular Formula:
    C25H22F4N4O5S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Lomeguatrib | MGMT inhibitor
    CAS:
    192441-08-0
    Catalog Number:
    10-4017
    Activity:
    MGMT inhibitor
    Chemical Name:
    2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
    Alternate Name:
    O6-(4-Bromothenyl)guanine
    Molecular Weight:
    326.17
    Molecular Formula:
    C10H8BrN5O3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming).
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All DNA Repair Products

DNA-PK

  • AZD7648 | DNA-PK inhibitor/CRISPR enhancer
    CAS:
    2230820-11-6
    Catalog Number:
    10-4108
  • NU7441 | DNA-PK inhibitor
    CAS:
    503468-95-9
    Catalog Number:
    10-4810
    Activity:
    DNA-PK inhibitor
    Chemical Name:
    8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
    Alternate Name:
    Ku-57788
    Molecular Weight:
    413.49
    Molecular Formula:
    C25H19NO3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming).
    Physical Properties:
    Off-white to beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All DNA-PK Products

Intercalation

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    CAS:
    23541-50-6
    Catalog Number:
    10-2429
    Activity:
    DNA Damaging Agent / Anticancer agent
    Alternate Names:
    Daunomycin; rubidomycin; RP-13057
    Molecular Weight:
    536.98
    Molecular Formula:
    C27H39NO10 • HCl
    Solubility:
    Soluble in water (up to 25 mg/ml)
    Physical Properties:
    Red solid
    Purity:
    95% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Epirubicin HCl | DNA damaging agent
    CAS:
    56390-09-1
    Catalog Number:
    10-2761
    Activity:
    DNA damaging agent
    Chemical Name:
    4′-Epidoxorubicin
    Molecular Weight:
    579.99
    Molecular Formula:
    C27H29NO11 HCl
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
    Physical Properties:
    Red orange solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Doxorubicin HCl | DNA damaging agent
    CAS:
    25316-40-9
    Catalog Number:
    10-2130
    Activity:
    DNA damaging agent
    Alternate Names:
    Adriamycin; NSC-123127
    Molecular Weight:
    579.99
    Molecular Formula:
    C27H29NO11 HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    Red-orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Intercalation Products

Markers

  • Chromomycin A3 | DNA Stain
    CAS:
    7059-24-7
    Catalog Number:
    10-2064
    Activity:
    DNA stain
    Chemical Names:
    Aburamycin B; CMA3; NSC-58514
    Molecular Weight:
    1183.25
    Molecular Formula:
    C57H82O26
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 8-Oxo-2′-deoxyguanosine | Marker for DNA damage
    CAS:
    88847-89-6
    Catalog Number:
    10-2690
    Activity:
    Marker for DNA damage
    Alternate Names:
    8-Oxo-dG; Oxo-dG
    Chemical Name:
    8-Oxo-7,8-dihydro-2′-deoxyguanosine
    Molecular Weight:
    283.25
    Molecular Formula:
    C10H13N5O5
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Markers Products

Other DNA Damage / Repair

View All Other DNA Damage / Repair Products

Oxidation

  • TH10785 | OGG1 activator
    CAS:
    1002801-51-5
    Catalog Number:
    10-5698
  • Ochratoxin A | Mycotoxin
    CAS:
    303-47-9
    Catalog Number:
    10-3562
  • Bleomycin sulfate | Induces double strand DNA breaks
    CAS:
    9041-93-4
    Catalog Number:
    10-2623
    Activity:
    Fibrosis-inducing agent
    Source:
    From Streptomyces verticillus
    Molecular Weight:
    1512.62
    Molecular Formula:
    C55H85N17O25S4
    Solubility:
    Soluble in Water (up to 20 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    Contains a mixture of A2 (~70%) and B2 (~30%) forms
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Epirubicin HCl | DNA damaging agent
    CAS:
    56390-09-1
    Catalog Number:
    10-2761
    Activity:
    DNA damaging agent
    Chemical Name:
    4′-Epidoxorubicin
    Molecular Weight:
    579.99
    Molecular Formula:
    C27H29NO11 HCl
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
    Physical Properties:
    Red orange solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Oxidation Products

p53

  • SR1078 | ROR agonist
    CAS:
    1246525-60-9
    Catalog Number:
    10-4066
  • Phenylhexyl isothiocyanate | Chemopreventive/HDAC inhibitor/p53 reactivator
    CAS:
    133920-06-6
    Catalog Number:
    10-5258
  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • RITA | p53 Activator
    CAS:
    213261-59-7
    Catalog Number:
    10-3385
    Activity:
    p53 Activator
    Chemical Names:
    5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol;
    NSC 652287
    Molecular Weight:
    292.37
    Molecular Formula:
    C14H12O3S2
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • UNC0379 | Selective SETD8 inhibitor
    CAS:
    1620401-82-2
    Catalog Number:
    10-4870
    Activity:
    Selective SETD8 inhibitor
    Chemical Name:
    6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
    Molecular Weight:
    413.56
    Molecular Formula:
    C23H35N5O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All p53 Products

PARG

  • GPI-16552 | PARG inhibitor
    CAS:
    443794-40-9
    Catalog Number:
    10-1502
    Activity:
    PARG inhibitor
    Chemical Name:
    N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide
    Molecular Weight:
    502.62
    Molecular Formula:
    C33H30N2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All PARG Products

PARP

  • Veliparib 2HCl | PARP 1/2 inhibitor
    CAS:
    912445-05-7
    Catalog Number:
    10-2419
    Activity:
    PARP 1/2 inhibitor
    Chemical Names:
    2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride
    Alternate Name:
    ABT-888
    Molecular Weight:
    317.22
    Molecular Formula:
    C13H16N4O·2HCl
    Solubility:
    Soluble in DMSO (30 mg/ml); water (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
  • Cordycepin | AMPK activator
    CAS:
    73-03-0
    Catalog Number:
    10-2408
    Activity:
    AMPK activator
    Chemical Name:
    3’-Deoxyadenosine
    Alternate Name:
    NSC 63984
    Molecular Weight:
    251.24
    Molecular Formula:
    C10H13N5O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% byHPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • UPF-1069 | PARP-2 inhibitor
    CAS:
    1048371-03-4
    Catalog Number:
    10-3779
    Activity:
    PPAR-2 inhibitor
    Chemical Name:
    5-(2-Oxo-3-phenylethoxy)-1(2H)-isoquinolinone
    Molecular Weight:
    279.29
    Molecular Formula:
    C17H13NO3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Rucaparib phosphate | PARP1 inhibitor
    CAS:
    459868-92-9
    Catalog Number:
    10-3321
    Activity:
    PARP1 inhibitor
    Chemical Name:
    8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
    Alternate Name:
    AG-14699; PF01367338
    Molecular Weight:
    421.36
    Molecular Formula:
    C19H18FN3O • H3PO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
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Topoisomerase

  • ICRF-193 | Topoisomerase II poison
    CAS:
    21416-88-6
    Catalog Number:
    10-5056
  • Ciprofloxacin HCl | Fluoroquinoline antibiotic
    CAS:
    86393-32-0
    Catalog Number:
    10-3917
    Activity:
    Fluoroquinoline antibiotic
    Chemical Names:
    1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinolin-3-carboxylic acid hydrochloride hydrate
    Molecular Weight:
    385.83
    Molecular Formula:
    C17H18FN3O3·HCl·H2O
    Solubility:
    Soluble in water (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Topotecan HCl | DNA topoisomerase I inhibitor
    CAS:
    119413-54-6
    Catalog Number:
    10-2479
  • ß-Lapachone | Topoisomerase-1 inhibitor
    CAS:
    4707-32-8
    Catalog Number:
    10-2386
    Activity:
    Topoisomerase I inhibitor
    Chemical Name:
    3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
    Alternate Name:
    NSC-26326
    Molecular Weight:
    242.27
    Molecular Formula:
    C15H14O3
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Epirubicin HCl | DNA damaging agent
    CAS:
    56390-09-1
    Catalog Number:
    10-2761
    Activity:
    DNA damaging agent
    Chemical Name:
    4′-Epidoxorubicin
    Molecular Weight:
    579.99
    Molecular Formula:
    C27H29NO11 HCl
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
    Physical Properties:
    Red orange solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Topoisomerase Products

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Plymouth Meeting, PA USA
1-855-FOCUS21

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