PhysioProcesses

Cardiovascular

Cardiovascular disease encompasses a broad range of pathologies including narrow or blocked blood vessels, heart muscle and valve failure, heart arrhythmias, and hypertension.

Arrhythmia

  • ML277 | Potent Kv7.1 activator
    CAS:
    1401242-74-7
    Catalog Number:
    10-4074
  • Norfluoxetine HCl | Fluoxetine Metabolite
    CAS:
    57226-68-3
    Catalog Number:
    10-2671
    Alternate Name:
    Desmethylfluoxetine
    Activity:
    Fluoxetine metabolite
    Chemical Name:
    3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)
    Molecular Weight:
    331.76
    Molecular Formula:
    C16H16F3NO HCl
    Solubility:
    Soluble in DMSO ( up to at least 25 mg/ml)
    Physical Properties:
    Beige waxy solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Disopyramide | Antiarrhythmic
    CAS:
    3737-09-5
    Catalog Number:
    10-4302
    Activity:
    Antiarrhythmic
    Chemical Name:
    4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide
    Molecular Weight:
    339.48
    Molecular Formula:
    C21H29N3O
    Solubility:
    Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL)
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Lorcainide HCl | Voltage-gated sodium channel blocker
    CAS:
    58934-46-6
    Catalog Number:
    10-1157
    Activity:
    Voltage-gated sodium channel blocker
    Chemical Name:
    N-(4-Chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide hydrochloride
    Molecular Weight:
    407.38
    Molecular Formula:
    C22H27ClN2O • HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Powder
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month
    Shipping Code:
    RT
  • Flecainide acetate | Sodium channel blocker
    CAS:
    54143-56-5
    Catalog Number:
    10-2992
    Activity:
    Sodium channel blocker
    Chemical Name:
    N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
    Molecular Weight:
    474.39
    Molecular Formula:
    C17H20F6N3O3 • C2H4O2
    Solubility:
    Soluble in DMSO (up to 45 mg/ml) or in Water (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Arrhythmia Products

Atherosclerosis

  • Lomitapide | Microsomal triglyceride transfer protein inhibitor
    CAS:
    182431-12-5
    Catalog Number:
    10-4664
  • Probucol | Antioxidant hypercholesterolemic agent
    CAS:
    23288-49-5
    Catalog Number:
    10-2679
  • Bempedoic acid | ATP citrate lyase inhibitor
    CAS:
    738606-46-7
    Catalog Number:
    10-4114
  • 1G244 | DPP8/9 inhibitor
    CAS:
    847928-32-9
    Catalog Number:
    10-4584
    Activity:
    DPP8/9 inhibitor
    Chemical Names:
    (S)-2-Amino-4-{4-[bis-(4-fluorophenyl)-methyl]piperazin-1-yl}-1-(1,3-dihydro-isoindol-2-yl)-butane-1,4-dione
    Alternate Name:
    PTX-1210
    Molecular Weight:
    504.57
    Molecular Formula:
    C29H30F2N4O2
    Solubility:
    Soluble in DMSO (>20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Belnacasan | ICE/caspase-1 inhibitor
    CAS:
    273404-37-8
    Catalog Number:
    10-4399
    Activity:
    ICE/caspase-1 inhibitor
    Chemical Names:
    (S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; VX-765
    Molecular Weight:
    508.99
    Molecular Formula:
    C24H33ClN4O6
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Atherosclerosis Products

Cardiac Stem Cells

  • PTC-209 | BMI-1 inhibitor
    CAS:
    315704-66-6
    Catalog Number:
    10-4022
    Activity:
    BMI-1 inhibitor
    Chemical Names:
    N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine
    Molecular Weight:
    495.19
    Molecular Formula:
    C17H13Br2N5OS
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    CAS:
    10045-45-1
    Catalog Number:
    10-3204
    Activity:
    K+ channel activator; Promotes cardiomyocyte differentiation
    Chemical Name:
    1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
    Alternate Names:
    1-Ethylbenzimidazolinone
    Molecular Weight:
    162.19
    Molecular Formula:
    C9H10N2O
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
    Physical Properties:
    Crystalline solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AS-8351 | KDM5B histone demethylase inhibitor
    CAS:
    796-42-9
    Catalog Number:
    10-1597
    Activity:
    KDM5B histone demethylase inhibitor
    Chemical Names:
    2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
    Molecular Weight:
    291.30
    Molecular Formula:
    C17H13N3O2
    Solubility:
    Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • XAV-939 | Tankyrase inhibitor/Cardiomyogenesis inducer
    CAS:
    284028-89-3
    Catalog Number:
    10-1186
    Activity:
    Tankyrase inhibitor / Cardiomyogenesis inducer
    Chemical Name:
    2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thino[4,3-d]pyrimidin-4-ol
    Molecular Weight:
    312.31
    Molecular Formula:
    C14H11F3N2OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SU-5402 | FGFR Phosphorylation inhibitor
    CAS:
    215543-92-3
    Catalog Number:
    10-2520
    Activity:
    FGFR Phosphorylation inhibitor
    Alternate Names:
    PF-02969207
    Chemical Name:
    3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
    Molecular Weight:
    296.32
    Molecular Formula:
    C17H16N2O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Cardiac Stem Cells Products

Cardioprotection

View All Cardioprotection Products

Heart Failure

  • AZD5904 | Myeloperoxidase inhibitor
    CAS:
    618913-30-7
    Catalog Number:
    10-4058
    Activity:
    Myeloperoxidase inhibitor
    Chemical Names:
    3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one
    Alternate Name:
    TX4
    Molecular Weight:
    252.29
    Molecular Formula:
    C10H12N4O2S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BI 749327 | Selective TRPC6 blocker
    CAS:
    2361241-23-6
    Catalog Number:
    10-4318
    Activity:
    Selective TRPC6 blocker
    Chemical Names:
    [4-(6-Aminopyridazin-3-yl)piperidin-1-yl]-[4-[4-(trifluoromethyl)phenoxy]phenyl]methanone
    Molecular Weight:
    442.44
    Molecular Formula:
    C23H21F3N4O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Metolazone | UPR activator and longevity inducer
    CAS:
    17560-51-9
    Catalog Number:
    10-5417
    Activity:
    UPR activator and longevity inducer
    Chemical Name:

    7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

    Molecular Weight:
    365.83
    Molecular Formula:
    C16H16ClN3O3S
    Solubility:
    Soluble in DMSO (up to 36 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
    Shipping Code:
    RT
  • PKSI-527 | Selective plasma kallikrein inhibitor
    CAS:
    128837-71-8
    Catalog Number:
    10-2220
    Activity:
    Selective plasma kallikrein inhibitor
    Chemical Names:
    trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
    Molecular Weight:
    474.01
    Molecular Formula:
    C25H31N3O4·HCl
    Solubility:
    Soluble in Water (5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Picotamide | Antiplatelet agent
    CAS:
    32828-81-2
    Catalog Number:
    10-3925
    Activity:
    Antiplatelet agent
    Molecular Weight:
    376.41
    Molecular Formula:
    C21H20N4O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Heart Failure Products

Hypertension

View All Hypertension Products

Ischemia

  • Muscone | Cardioprotective and neuroprotective agent
    CAS:
    541-91-3
    Catalog Number:
    10-2757
  • Apixaban | Factor Xa inhibitor
    CAS:
    503612-47-3
    Catalog Number:
    10-5660
    Activity:
    Factor Xa inhibitor
    Chemical Names:
    4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
    Molecular Weight:
    459.51
    Molecular Formula:
    C25H25N5O4
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Bepridil | Calcium channel blocker\Active against SARS-CoV2
    CAS:
    74764-40-2
    Catalog Number:
    10-4958
    Activity:
    Calcium channel blocker/anti-SARS-CoV2
    Chemical Name:
    N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline hydrochloride
    Molecular Weight:
    403.00
    Molecular Formula:
    C24H34N2O·HCl
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Anagrelide HCl | PDE3 inhibitor
    CAS:
    58579-51-4
    Catalog Number:
    10-1220
    Activity:
    PDE3 inhibitor
    Chemical Name:
    6,7-dichloro-1,5-dihydroimidazo[2,1 –b]quinazolin-2(3H)-one hydrochloride
    Alternate Names:
    BL-4162A
    Molecular Weight:
    292.55
    Molecular Formula:
    C10H7Cl2N3O • HCl
    Solubility:
    Soluble in DMSO (up to 2.5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Go-6983 | PKC inhibitor
    CAS:
    133053-19-7
    Catalog Number:
    10-2621
    Activity:
    PKC inhibitor
    Chemical Names:
    3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
    Molecular Weight:
    442.51
    Molecular Formula:
    C26H26N4O3
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Red-orange solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Ischemia Products

Lipid Metabolism

  • Bempedoic acid | ATP citrate lyase inhibitor
    CAS:
    738606-46-7
    Catalog Number:
    10-4114
  • Firsocostat | Allosteric acetyl-CoA carboxylase inhibitor
    CAS:
    1434635-54-7
    Catalog Number:
    10-4699
    Activity:
    Allosteric ACC inhibitor
    Chemical Names:
    2-[1-[(2R)-2-(2-Methoxyphenyl)-2-9oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
    Alternate Name:
    ND-630; NDI-010976; GS-0976
    Molecular Weight:
    569.63
    Molecular Formula:
    C28H31N3O8S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BMS-303141 | ATP citrate lyase (ACL) inhibitor
    CAS:
    943962-47-8
    Catalog Number:
    10-1414
    Activity:
    ATP citrate lyase (ACL) inhibitor
    Chemical Name:
    3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide
    Molecular Weight:
    424.30
    Molecular Formula:
    C19H15Cl2NO4S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ezetimibe | Cholesterol absorption inhibitor
    CAS:
    163222-33-1
    Catalog Number:
    10-2027
    Activity:
    Cholesterol absorption inhibitor
    Chemical Name:
    (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one
    Alternate Names:
    SCH 58235; Ezetrol
    Molecular Weight:
    409.43
    Molecular Formula:
    C24H21F2NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Atglistatin | ATGL inhibitor
    CAS:
    1469924-27-3
    Catalog Number:
    10-4598
    Activity:
    ATGL inhibitor
    Chemical Name:
    N’-[4’-(Dimethylamino)[1,1’-biphenyl]-3-yl]-N,N,-dimethylurea
    Molecular Weight:
    283.37
    Molecular Formula:
    C17H21N3O
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Lipid Metabolism Products

20% OFF

For Postdoc
Customers!

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Menu
Menu
Menu
Menu
VIEW DISTRIBUTORS LIST
Facebook Twitter Linkedin
Menu
Menu

Website Created by Advanta Advertising LLC.