Immunology

The human immune system is composed of two major parts, the adaptive immune system and the innate immune system. The initial reaction to a pathogen involves the innate system, a non-specific response that involves inflammation, leukocytes, and the complement system. The adaptive immune system response is carried out by B cell and T cell lymphocytes. B cells are activated to secrete antibodies to the pathogen, present antigen, and secrete cytokines and various T cells kill target cells, activate macrophages, and stimulate B cells to produce antibodies. The adaptive immune system also creates immunological memory through memory B and T cells that provide enhanced protection to future infection.

Adenosine A2A

  • Preladenant | Potent and selective adenosine A2A antagonist
    CAS:
    377727-87-2
    Catalog Number:
    10-4102
    Chemical Name:
    4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
    Alternate Name:
    SCH 420814
    Molecular Weight:
    503.57
    Molecular Formula:
    C29H29N9O3
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming).
    Physical Properties:
    Beige solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • CPI-444 | Adenosine A2A receptor antagonist
    CAS:
    1202402-40-1
    Catalog Number:
    10-4101
    Activity:
    Adenosine A2A receptor antagonist
    Chemical Name:
    7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
    Alternate Name:
    Ciforadenant
    Molecular Weight:
    407.43
    Molecular Formula:
    C20H21N7O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Adenosine A2A Products

Cancer immunotherapy

  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • JPH203 | LAT1 inhibitor
    CAS:
    1597402-27-1
    Catalog Number:
    10-4464
    Activity:
    LAT1 inhibitor
    Chemical Names:
    (2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride
    Alternate Name:
    KYT-0353; Nanvuralant
    Molecular Weight:
    545.24
    Molecular Formula:
    C23H19Cl2N3O4·2HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale orange/yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Luminespib | HSP90 inhibitor
    CAS:
    747412-49-3
    Catalog Number:
    10-4672
    Activity:
    HSP90 inhibitor
    Chemical Names:
    5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
    Alternate Name:
    NVP-AUY922; VER-52296
    Molecular Weight:
    465.54
    Molecular Formula:
    C26H31N3O5
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • BX795 | Dual TBK1/IKKε inhibitor – enhances lentiviral transduction efficiency
    CAS:
    702675-74-9
    Catalog Number:
    10-4677
    Activity:
    Dual inhibitor of TBK1/IKKε
    Chemical Names:
    N-[3-[[5-Iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
    Molecular Weight:
    591.47
    Molecular Formula:
    C23H26IN7O2S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ganetespib | HSP90 inhibitor
    CAS:
    888216-25-9
    Catalog Number:
    10-4474
    Activity:
    HSP90 inhibitor
    Chemical Name:

    3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

    Molecular Weight:
    364.40
    Molecular Formula:
    C20H20N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cancer immunotherapy Products

Chemokines

  • SX-682 | CXCR1/2 inhibitor
    CAS:
    1648843-04-2
    Catalog Number:
    10-4925
    Activity:
    CXCR1/2 inhibitor
    Chemical Names:
    [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid
    Molecular Weight:
    467.20
    Molecular Formula:
    C19H14BF4N3O4S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AZD2098 | CCR4 antagonist
    CAS:
    566203-88-1
    Catalog Number:
    10-4262
    Activity:
    CCR4 antagonist
    Chemical Names:
    2,3-Dichloro-N-(3-methoxypyrazine-2-yl)benzenesulfonamide
    Molecular Weight:
    334.17
    Molecular Formula:
    C11H9Cl2N3O3S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white/beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • CDN1163 | SERCA activator
    CAS:
    892711-75-0
    Catalog Number:
    10-4627
    Activity:
    Allosteric SERCA activator
    Chemical Names:
    4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
    Molecular Weight:
    320.39
    Molecular Formula:
    C20H20N2O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Plerixafor | CXCR4 antagonist
    CAS:
    155148-31-5
    Catalog Number:
    10-2864
    Activity:
    CXCR4 antagonist
    Molecular Weight:
    794.48
    Molecular Formula:
    C28H54N8 • 8HCl
    Solubility:
    Soluble in Water (up to at least 55 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • GSK583 | RIP2 kinase inhibitor
    CAS:
    1346547-00-9
    Catalog Number:
    10-4761
    Activity:
    RIP2 kinase inhibitor
    Chemical Name:
    6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine
    Molecular Weight:
    398.45
    Molecular Formula:
    C20H19FN4O2S
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Chemokines Products

Cytokines

  • Sotrastaurin
    CAS:
    425637-18-9
    Catalog Number:
    10-4350
    Molecular Weight:
    438.48
  • Locostatin | RKIP/Raf-1 kinase disruptor
    CAS:
    133812-16-5
    Catalog Number:
    10-5381
    Activity:
    RKIP/Raf-1 kinase disruptor
    Chemical Names:
    (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005
    Molecular Weight:
    245.28
    Molecular Formula:
    C14H15O3
    Solubility:
    Soluble in DMSO (60 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Methotrexate | Dihydrofolate reductase inhibitor
    CAS:
    133073-73-1
    Catalog Number:
    10-1260
    Activity:
    Dihydrofolate reductase inhibitor
    Chemical Names:
    N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740
    Molecular Weight:
    683.63
    Molecular Formula:
    C20H22N8O5·XH2O
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Apilimod | IL-12 and 23/PIKfyve inhibitor
    CAS:
    541550-19-0
    Catalog Number:
    10-4970
    Activity:
    IL-12 and 23/PIKfyve inhibitor
    Chemical Names:
    N-[(E)-(3-Methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine; STA5326
    Molecular Weight:
    418.50
    Molecular Formula:
    C23H26N6O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • CDN1163 | SERCA activator
    CAS:
    892711-75-0
    Catalog Number:
    10-4627
    Activity:
    Allosteric SERCA activator
    Chemical Names:
    4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
    Molecular Weight:
    320.39
    Molecular Formula:
    C20H20N2O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Cytokines Products

Glucocorticoid receptors

  • Dexamethasone | Apoptosis inducing glucocorticoid
    CAS:
    50-02-2
    Catalog Number:
    10-1134
    Activity:
    Apoptosis inducing glucocorticoid
    Chemical Name:
    (11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    Molecular Weight:
    392.46
    Molecular Formula:
    C22H29FO5
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
View All Glucocorticoid receptors Products

Histamine

  • Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination
    CAS:
    14976-57-9
    Catalog Number:
    10-4644
  • Tranilast | Antiallergy agent
    CAS:
    53902-12-8
    Catalog Number:
    10-2234
    Activity:
    NFκB inhibitor
    Alternate Names:
    Rizaben
    Chemical Name:
    N-(3′,4′-Dimethoxycinnamoyl)anthranilic acid
    Molecular Weight:
    327.34
    Molecular Formula:
    C18H17NO5
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforrms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Astemizole | hERG channel blocker
    CAS:
    68844-77-9
    Catalog Number:
    10-1064
    Activity:
    hERG channel blocker
    Chemical Name:
    1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
    Molecular Weight:
    457.58
    Molecular Formula:
    C28H31FN4O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Histamine Products

IDO

  • NLG919 | IDO pathway inhibitor
    CAS:
    1402836-58-1
    Catalog Number:
    10-4564
    Activity:
    IDO pathway inhibitor
    Chemical Names:
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
    Molecular Weight:
    282.39
    Molecular Formula:
    C18H22N2O
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Epacadostat | IDO1 inhibitor
    CAS:
    1204669-58-8
    Catalog Number:
    10-4499
    Activity:
    IDO1 inhibitor/ Cancer immunotherapy enhancer
    Chemical Name:
    N-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
    Alternate Name:
    INCB024360
    Molecular Weight:
    438.23
    Molecular Formula:
    C11H13BrFN7O4S
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PF-06840003 | IDO1 inhibitor
    CAS:
    198474-05-4
    Catalog Number:
    10-4498
    Activity:
    IDO1 inhibitor/Cancer immunotherapy enhancer
    Chemical Name:
    3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
    Alternate Name:
    EOS200271
    Molecular Weight:
    232.21
    Molecular Formula:
    C12H9FN2O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tryptanthrin | Immunomodulator/IDO2 inhibitor
    CAS:
    13220-57-0
    Catalog Number:
    10-2228
    Activity:
    Immunomodulator; IDO2 inhibitor
    Chemical Name:
    Indolo(2,1-b)quinazoline-6,12-dione
    Alternate Names:
    NSC 349447; Couroupitine A
    Molecular Weight:
    248.24
    Molecular Formula:
    C15H8N2O2
    Solubility:
    Soluble in DMSO (up to 24 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Indoximod | IDO modulator / tryptophan mimetic
    CAS:
    110117-83-4
    Catalog Number:
    10-4569
    Activity:
    IDO modulator / tryptophan mimetic
    Chemical Name:
    1-Methyl-D-tryptophan
    Molecular Weight:
    218.25
    Molecular Formula:
    C12H14N2O2
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All IDO Products

Immunosuppressants

View All Immunosuppressants Products

Kinases

View All Kinases Products

Leukotriene receptors

  • Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    CAS:
    103177-37-3
    Catalog Number:
    10-2441
    Activity:
    Leukotriene CysLT1 antagonist / GRP17 antagonist
    Chemical Name:
    N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
    Alternate Names:
    ONO-1078
    Molecular Weight:
    481.51
    Molecular Formula:
    C27H23N5O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Zafirlukast | HSP70 inhibitor and leukotriene antagonist
    CAS:
    107753-78-6
    Catalog Number:
    10-1100
    Activity:
    Hsp70 inhibitor
    Alternate Names:
    ICI-204219
    Molecular Weight:
    575.69
    Molecular Formula:
    C31H33N3O6S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White or pink solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • MK-571 | Cys LT1 antagonist
    CAS:
    115104-28-4
    Catalog Number:
    10-1039
    Activity:
    Cys LT1 antagonist
    Alternate Names:
    L-660711
    Chemical Name:
    5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid
    Molecular Weight:
    515.09
    Molecular Formula:
    C26H27ClN2O3S2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    95% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Leukotriene receptors Products

Lipoxygenase

  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells
    CAS:
    491-67-8
    Catalog Number:
    10-2773
    Activity:
    Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Chemical Name:
    5,6,7-Trihydroxyflavone
    Molecular Weight:
    270.24
    Molecular Formula:
    C15H10O5
    Physical Properties:
    Yellow or yellow-green solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
    Shipping Code:
    RT
  • Zileuton | 5-LO inhibitor
    CAS:
    111406-87-2
    Catalog Number:
    10-1098
    Activity:
    5-LO inhibitor
    Chemical Name:
    N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
    Molecular Weight:
    236.29
    Molecular Formula:
    C11H12N2O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • MK-886 | FLAP inhibitor
    CAS:
    118414-82-7
    Catalog Number:
    10-1040
    Activity:
    FLAP inhibitor
    Alternate Names:
    L-663,536
    Chemical Name:
    3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
    Molecular Weight:
    472.08
    Molecular Formula:
    C27H34ClNO2S
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Lipoxygenase Products

NF-kB

  • EV-96 | Cysteine-reactive T cell activation suppressor
    CAS:
    N/A
    Catalog Number:
    10-3949
  • 2E151 | Vaccine co-adjuvant
    CAS:
    2416963-37-4
    Catalog Number:
    10-4145
  • Tryptanthrin | Immunomodulator/IDO2 inhibitor
    CAS:
    13220-57-0
    Catalog Number:
    10-2228
    Activity:
    Immunomodulator; IDO2 inhibitor
    Chemical Name:
    Indolo(2,1-b)quinazoline-6,12-dione
    Alternate Names:
    NSC 349447; Couroupitine A
    Molecular Weight:
    248.24
    Molecular Formula:
    C15H8N2O2
    Solubility:
    Soluble in DMSO (up to 24 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Rocaglamide | TNFalpha inhibitor
    CAS:
    84573-16-0
    Catalog Number:
    10-2484
    Activity:
    TNFalpha inhibitor
    Molecular Weight:
    505.57
    Molecular Formula:
    C29H31NO7
    Solubility:
    Soluble in DMSO or Ethanol
    Physical Properties:
    White solid supplied as a thin film on vial.
    Purity:
    97% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.
    Shipping Code:
    RT
  • Triptolide | Immunosuppressant
    CAS:
    38748-32-2
    Catalog Number:
    10-2631
    Activity:
    Immunsuppressant
    Chemical Name:
    (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
    Alternate Names:
    PG490
    Molecular Weight:
    360.40
    Molecular Formula:
    C20H24O6
    Solubility:
    Soluble in DMSO (up to 7 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All NF-kB Products

Other Immunology

View All Other Immunology Products

Pattern recognition receptors

  • Vesatolimod | TLR7 agonist/antiviral
    CAS:
    1228585-88-3
    Catalog Number:
    10-4921
    Activity:
    TLR7 agonist
    Chemical Names:
    4-Amino-2-butoxy-8-[[3-(pyrrolidine-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one
    Alternate Name:
    GS-9620
    Molecular Weight:
    410.52
    Molecular Formula:
    C22H30N6O2
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Loxoribine | TLR7 agonist
    CAS:
    121288-39-9
    Catalog Number:
    10-3780
    Activity:
    TLR7 agonist
    Chemical Name:
    7-Allyl-7,8-dihydro-8-oxoguanosine
    Alternate Name:
    RWJ-21757
    Molecular Weight:
    339.30
    Molecular Formula:
    C13H17N5O6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    96% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Allopregnanolone | GABA-A positive allosteric modulator
    CAS:
    516-54-1
    Catalog Number:
    10-3489
    Activity:
    GABA-A positive allosteric modulator
    Chemical Name:
    (3α,5α)-3-Hydroxy-pregnan-20-one
    Alternate Name:
    (3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
    Molecular Weight:
    318.49
    Molecular Formula:
    C21H34O2
    Solubility:
    Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Imiquimod | TLR7 Agonist
    CAS:
    99011-02-6
    Catalog Number:
    10-4230
    Alternate Name:
    R837
    Activity:
    TLR7 agonist
    Chemical Name:
    1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine
    Molecular Weight:
    240.30
    Molecular Formula:
    C14H16N4
    Solubility:
    Soluble in DMSO (2 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Motolimod | TLR8 agonist
    CAS:
    926927-61-9
    Catalog Number:
    10-4920
    Activity:
    TLR8 agonist/Cancer immunotherapy enhancer
    Alternate Name:
    VTX-2337
    Chemical Name:
    2-Amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-1-benzapine-4-carboxamide
    Molecular Weight:
    458.61
    Molecular Formula:
    C28H34N4O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white or pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Pattern recognition receptors Products

Prostanoid receptors & prostaglandins

  • Grapiprant | EP4 Receptor antagonist
    CAS:
    415903-37-6
    Catalog Number:
    10-4006
    Activity:
    EP4 Receptor antagonist
    Chemical Name:
    1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
    Alternate Names:
    CJ-023423; ARY-007
    Molecular Weight:
    491.61
    Molecular Formula:
    C26H29N5O3S
    Solubility:
    Soluble in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Prostaglandin E2 | Prostaglandin E (EP) receptor agonist
    CAS:
    363-24-6
    Catalog Number:
    10-1358
    Activity:
    Prostaglandin E (EP) receptor agonist
    Alternate Names:
    Dinoprost
    Chemical Name:
    (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
    Molecular Weight:
    352.47
    Molecular Formula:
    C20H32O5
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    Blue Ice
  • Zileuton | 5-LO inhibitor
    CAS:
    111406-87-2
    Catalog Number:
    10-1098
    Activity:
    5-LO inhibitor
    Chemical Name:
    N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
    Molecular Weight:
    236.29
    Molecular Formula:
    C11H12N2O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Prostanoid receptors & prostaglandins Products

RORγt

  • SR0987 |RORγt agonist
    CAS:
    303126-97-8
    Catalog Number:
    10-4008
    Activity:
    RORγt Agonist/Cancer immunotherapy enhancer
    Chemical Name:
    2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
    Molecular Weight:
    397.70
    Molecular Formula:
    C16H10F6NO2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All RORγt Products

STING

  • NVS-STG2 | Molecular glue STING agonist
    CAS:
    3030588-01-0
    Catalog Number:
    10-4134
  • STING Degrader 2 | STING molecular glue
    CAS:
    N/A
    Catalog Number:
    10-3939
  • SR-717 | STING agonist
    CAS:
    2375421-09-1
    Catalog Number:
    10-4850
    Activity:
    STING agonist
    Chemical Names:
    Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
    Molecular Weight:
    381.27
    Molecular Formula:
    C15H8F2N5O3·Li
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
    Shipping Code:
    RT
  • RU.521 | cGAS Inhibitor
    CAS:
    2262452-06-0
    Catalog Number:
    10-4140
    Activity:
    cGAS Inhibitor
    Chemical Name:

    3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

    Molecular Weight:
    415.23
    Molecular Formula:
    C19H12Cl2N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • CPI-455 | Lysine demethylase KDM5 inhibitor
    CAS:
    1628208-23-0
    Catalog Number:
    10-4035
    Activity:
    Lysine demethylase KDM5 inhibitor
    Chemical Name:
    7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
    Molecular Weight:
    278.32
    Molecular Formula:
    C16H14N4O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All STING Products

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View All TGF-b Products

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Plymouth Meeting, PA USA
1-855-FOCUS21

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