Ions and other channels

Ion Channels are pore-forming proteins that allow the selective passage of ions through plasma or intracellular organelle membranes based on an electric gradient. In addition to transducing electrical currents in the body, they play a role in cellular signaling, pH regulation, and cell volume regulation. Ion channels can be defined by what opens and closes the channel: voltage-gated channels open and close based on the voltage gradient across the plasma membrane or ligand-gated channels by the binding of various ligands to the channel. They are also be defined by the type of ion that selectively passes through (calcium, sodium, potassium etc.) or by the physical stimulation that opens or closes them (mechanosensitive, light sensitive, or temperature sensitive). Many disease states are caused by perturbed ion channel function (channelopathies) including epilepsy, cystic fibrosis, long QT syndrome, and various musculo-skeletal disorders. Pharmacologic manipulation of ion channels is widely used to treat cardiovascular disorders, pain, diabetes, constipation and is being investigated for use in cancer, inflammation, immunomodulation, kidney diseases and infection.

AMPA

  • Domoic acid | Marine natural product neurotoxin
    CAS:
    14277-97-5
    Catalog Number:
    10-2472
  • Cyclothiazide | AMPA receptor positive allosteric modulator
    CAS:
    2259-96-3
    Catalog Number:
    10-2449
    Activity:
    AMPA receptor positiv e allosteric modulator
    Chemical Name:
    6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
    Alternate Names:
    LY-35483
    Molecular Weight:
    389.88
    Molecular Formula:
    C14H16ClN3O4S2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • L-Theanine | Neuroprotectant
    CAS:
    3081-61-6
    Catalog Number:
    10-4513
    Activity:
    GABA agonist
    Chemical Name:
    N-Ethyl-L-glutamine
    Molecular Weight:
    174.2
    Molecular Formula:
    C7H14N2O3
    Solubility:
    Soluble in Water (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All AMPA Products

Aquaporins

  • AqB013 | Aquaporin blocker
    CAS:
    1021869-51-1
    Catalog Number:
    10-5723
  • TGN-020 | Aquaporin 4 blocker
    CAS:
    51987-99-6
    Catalog Number:
    10-1546
    Activity:
    Aquaporin 4 blocker
    Chemical Name:
    N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
    Molecular Weight:
    206.22
    Molecular Formula:
    C8H6N4OS
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • CVPA | Aquaporin 1 inhibitor
    CAS:
    37710-81-9
    Catalog Number:
    10-1430
    Activity:
    Aquaporin 1 inhibitor
    Alternate Names:
    3,3′-(1,3-Phenylene)bis(2-propenoic acid)
    Chemical Name:
    3-[3-(2-Carboxy-vinyl)-phenyl]-acrylic acid
    Molecular Weight:
    218.21
    Molecular Formula:
    C12H10O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of pruchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Aquaporins Products

Calcium

  • CBD3063 | Cav2.2 blocker
    CAS:
    1281060-70-5
    Catalog Number:
    10-4954
  • YM-58483 | CRAC channel blocker
    CAS:
    223499-30-7
    Catalog Number:
    10-2935
    Activity:
    CRAC channel blocker
    Chemical Names:
    N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
    Alternate Name:
    BTP2
    Molecular Weight:
    421.32
    Molecular Formula:
    C15H9F6N5OS
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Manidipine dihydrochloride | Calcium channel blocker
    CAS:
    89226-75-5
    Catalog Number:
    10-2045
    Activity:
    Calcium channel blocker
    Chemical Names:
    5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
    Alternate Name:
    CV-4093
    Molecular Weight:
    683.63
    Molecular Formula:
    C35H38N4O6·2HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ionomycin Ca | Calcium Ionophore
    CAS:
    56092-82-1
    Catalog Number:
    10-2078
    Activity:
    Calcium ionophore
    Fermentation product from:
    Streptomyces conglobatus
    Molecular Weight:
    747.07
    Molecular Formula:
    C41H70O9·Ca
    Solubility:
    Soluble in DMSO (10 mg/ml); Ethanol (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • TTA-P2 | Potent and selective T-type calcium channel antagonist
    CAS:
    918430-49-6
    Catalog Number:
    10-3993
    Activity:
    Selective T-type calcium channel antagonist
    Chemical Names:
    (±)-3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
    Molecular Weight:
    431.37
    Molecular Formula:
    C21H29Cl2FN2O2
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    >97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Calcium Products

Chloride

  • Milbemectin | RDL GABA agonist and Glutamate-gated Cl channel activator
    CAS:
    1799297-76-9
    Catalog Number:
    10-5257
  • Glyburide | K-ATP channel blocker
    CAS:
    10238-21-8
    Catalog Number:
    10-1325
    Activity:
    K-ATP channel blocker
    Alternate Names:
    Glibenclamide
    Chemical Name:
    5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]suphonyl]phenyl]ethyl]-2-methoxybenzamide
    Molecular Weight:
    494.01
    Molecular Formula:
    C23H28ClN3O5S
    Solubility:
    Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Chloride Products

GABAA

  • Flumazenil | Benzodiazepine antagonist
    CAS:
    78755-81-4
    Catalog Number:
    10-1081
    Activity:
    Benzodiazepine antagonist
    Chemical Name:

    8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

    Alternate Names:

    Ro 1722;  Ro 15-1788

    Molecular Weight:
    303.29
    Molecular Formula:
    C15H14FN3O3
    Solubility:
    Soluble in DMSO (up to 8 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor
    CAS:
    145821-59-6
    Catalog Number:
    10-4384
    Activity:
    GABA transporter 1 (GAT1) inhibitor
    Chemical Name:
    (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
    Alternate Name:
    NO-328
    Molecular Weight:
    412.00
    Molecular Formula:
    C20H25NO2S2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Allopregnanolone | GABA-A positive allosteric modulator
    CAS:
    516-54-1
    Catalog Number:
    10-3489
    Activity:
    GABA-A positive allosteric modulator
    Chemical Name:
    (3α,5α)-3-Hydroxy-pregnan-20-one
    Alternate Name:
    (3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
    Molecular Weight:
    318.49
    Molecular Formula:
    C21H34O2
    Solubility:
    Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Flupirtine maleate | K+ channel activator
    CAS:
    75507-68-5
    Catalog Number:
    10-2416
    Activity:
    K+ channel activator
    Chemical Name:
    N-[2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
    Alternate Names:
    D9998
    Molecular Weight:
    420.39
    Molecular Formula:
    C15H17FN4O2 • C4H4O4
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Muscimol HBr | GABA-A agonist
    CAS:
    18174-72-6
    Catalog Number:
    10-1448
    Activity:
    GABA-A receptor agonist
    Chemical Name:
    5-Aminomethyl-3-hydroxyisoxazole hydrobromide
    Molecular Weight:
    234.21
    Molecular Formula:
    C14H6N2O2 •HBr
    Solubility:
    Soluble in Water (up to 10 mg/ml). Also soluble in DMSO and Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All GABAA Products

Ionophores

  • Cereulide | Mitochondrial toxin
    CAS:
    157232-64-9
    Catalog Number:
    10-2746
    Activity:
    Mitochondrial toxin
    Source:
    Isolated from Bacillus cereus
    Molecular Weight:
    1153.40
    Molecular Formula:
    C57H96N6O18
    Solubility:
    Soluble in DMSO or Ethanol
    Supplier As:
    Supplied in Methanol at a concentration of 25μg/500μl
    Purity:
    98% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Diluted solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Salinomycin Na | Cancer stem cell inhibitor
    CAS:
    55721-31-8
    Catalog Number:
    10-2654
    Activity:
    Cancer stem cell inhibitor
    Chemical Name:
    from Streptomyces albus
    Molecular Weight:
    772.98
    Molecular Formula:
    C42H69O11 Na
    Solubility:
    Soluble in DMSO.
    Physical Properties:
    White solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Valinomycin | Induces loss of mitochondrial membrane potential
    CAS:
    2001-95-8
    Catalog Number:
    10-2112
    Activity:
    Induces loss of mitochondrial membrane potential
    Chemical Name:
    Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3
    Molecular Weight:
    1111.35
    Molecular Formula:
    C54H90N6O18
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Nigericin Na | Induces rapid intracellular acidification
    CAS:
    28643-80-3
    Catalog Number:
    10-2089
    Activity:
    Induces rapid intracellular acidification
    Alternate Names:
    Antibiotic K178, Antibiotic X-464, Azalomycin M, PolyetherinA
    Molecular Weight:
    746.96
    Molecular Formula:
    C40H57O11 Na
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Nonactin | Monovalent cation ionophore K+ and NH4+
    CAS:
    6833-84-7
    Catalog Number:
    10-2090
    Activity:
    Monovalent cation ionophore (K+ and NH4+)
    Alternate Names:
    Polynactin; Werramycin A
    Chemical Name:
    Isolated from Streptomyces griseus
    Molecular Weight:
    736.95
    Molecular Formula:
    C40H64O12
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Ionophores Products

Kainate

  • Domoic acid | Marine natural product neurotoxin
    CAS:
    14277-97-5
    Catalog Number:
    10-2472
  • L-Theanine | Neuroprotectant
    CAS:
    3081-61-6
    Catalog Number:
    10-4513
    Activity:
    GABA agonist
    Chemical Name:
    N-Ethyl-L-glutamine
    Molecular Weight:
    174.2
    Molecular Formula:
    C7H14N2O3
    Solubility:
    Soluble in Water (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Kainic acid | Kainate receptor agonist/neurotoxin
    CAS:
    487-79-6
    Catalog Number:
    10-2453
    Activity:
    Kainate receptor agonist; neurotoxin
    Chemical Name:
    (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid, hydrate
    Molecular Weight:
    213.24
    Molecular Formula:
    C10H15NO4 (xH2O)
    Solubility:
    Soluble in Water (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Kainate Products

Nicotinic acetylcholine (nAChR)

  • PNU 282987 | nAChR agonist
    CAS Number:
    123464-89-1
    Catalog Number:
    10-4496
    Activity:
    nAChR agonist
    Chemical Name:
    N-(3R)-1-Azabicyclo[2.2.2}oct-3-yl-4-chlorobenzamide
    Molecular Weight:
    264.75
    Molecular Formula:
    C14H17ClN2O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Nicotinic acetylcholine (nAChR) Products

NMDA

  • Huperzine A | Acetylcholinesterase Inhibitor
    CAS:
    102518-79-6
    Catalog Number:
    10-2399
  • Flupirtine maleate | K+ channel activator
    CAS:
    75507-68-5
    Catalog Number:
    10-2416
    Activity:
    K+ channel activator
    Chemical Name:
    N-[2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
    Alternate Names:
    D9998
    Molecular Weight:
    420.39
    Molecular Formula:
    C15H17FN4O2 • C4H4O4
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Memantine HCl | NMDA antagonist / Anti-Alzheimer’s
    CAS:
    41100-52-1
    Catalog Number:
    10-2346
    Activity:
    NMDA antagonist / Anti-Alzheimer’s
    Chemical Name:
    3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
    Alternate Names:
    3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
    Molecular Weight:
    215.76
    Molecular Formula:
    C12H21N • HCl
    Solubility:
    Soluble in Water (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Ibotenic acid | NMDA and mGluR agonist
    CAS:
    2552-55-8
    Catalog Number:
    10-2693
    Activity:
    NMDA and mGluR agonist
    Chemical Name:
    α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate
    Molecular Weight:
    176.13
    Molecular Formula:
    C5H6N2O4 • H2O
    Solubility:
    Soluble in Water (up to 1 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • D(+)-Cycloserine | NMDA, glycine site partial agonist
    CAS:
    68-41-7
    Catalog Number:
    10-2279
    Activity:
    NMDA, glycine site partial agonist
    Chemical Name:
    (R)-4-Amino-3-isoxazolidone
    Molecular Weight:
    102.09
    Molecular Formula:
    C3H6N2O2
    Solubility:
    Soluble in Water (up to 100 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All NMDA Products

Other Ions and Other Channels

  • T-10418 | G2A agonist
    CAS:
    1608784-68-4
    Catalog Number:
    10-4916
  • Ivabradine HCl | Heart failure / unstable angina drug
    CAS:
    1448849-67-6
    Catalog Number:
    10-2694
    Activity:
    Heart failure / unstable angina drug
    Chemical Name:
    3-[3-[[(7S)-3,4-Dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
    Molecular Weight:
    505.05
    Molecular Formula:
    C27H36N2O5 • HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Riluzole | Sodium channel blocker / Neuroprotective
    CAS:
    1744-22-5
    Catalog Number:
    10-2815
    Activity:
    Sodium channel blocker / Neuroprotective
    Chemical Name:
    2-Amino-6-(trifluoromethoxy)benzothiazole
    Molecular Weight:
    234.20
    Molecular Formula:
    C8H5F3N2OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • 2GBI | Hv1 channel blocker
    CAS:
    5418-95-1
    Catalog Number:
    10-3127
    Activity:
    Hv1 channel blocker
    Chemical Name:
    2-Guanidinobenzimidazole
    Molecular Weight:
    175.19
    Molecular Formula:
    C8H9N5
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
    Physical Properties:
    Beige solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Other Ions and Other Channels Products

P2X

  • BAY-1797 | P2X4 antagonist
    CAS:
    2055602-83-8
    Catalog Number:
    10-3980
    Activity:
    P2X4 antagonist
    Chemical Names:
    N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
    Molecular Weight:
    416.88
    Molecular Formula:
    C20H17ClN2O4S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale brown solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • A-438079 HCl | P2X7 antagonist
    CAS:
    899431-18-6
    Catalog Number:
    10-4063
    Activity:
    P2X7 antagonist
    Chemical Names:
    3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
    Molecular Weight:
    342.61
    Molecular Formula:
    C13H9Cl2N5·HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All P2X Products

Potassium

View All Potassium Products

Sodium

  • ICA-121431 | Selective Sodium channel blocker
    CAS:
    313254-51-2
    Catalog Number:
    10-4085
    Activity:
    Selective Nav1.1/1.3 inhibitor
    Chemical Names:
    2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
    Molecular Weight:
    449.54
    Molecular Formula:
    C23H19N3O3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to beige solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PF-05089771 | Selective Nav1.7 inhibitor
    CAS:
    1235403-62-9
    Catalog Number:
    10-3990
    Activity:
    Selective Nav1.7 channel blocker
    Chemical Name:
    4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
    Alternate Name:
    PF771
    Molecular Weight:
    500.34
    Molecular Formula:
    C18H12Cl2FN5O3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AA43279 | Nav1.1 activator
    CAS:
    354812-16-1
    Catalog Number:
    10-3503
    Activity:
    Nav1.1 activator
    Chemical Name:
    3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
    Molecular Weight:
    248.30
    Molecular Formula:
    C12H12N2O2S
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    Tan solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Rufinamide | Anticonvulsant / Improves cognition
    CAS:
    106308-44-5
    Catalog Number:
    10-4275
    Activity:
    Anticonvulsant / Improves cognition
    Chemical Name:
    1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
    Molecular Weight:
    238.19
    Molecular Formula:
    C10H8F2N4O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Riluzole | Sodium channel blocker / Neuroprotective
    CAS:
    1744-22-5
    Catalog Number:
    10-2815
    Activity:
    Sodium channel blocker / Neuroprotective
    Chemical Name:
    2-Amino-6-(trifluoromethoxy)benzothiazole
    Molecular Weight:
    234.20
    Molecular Formula:
    C8H5F3N2OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Sodium Products

TRP

  • Arvanil | TRPV1 channel activator
    CAS:
    128007-31-8
    Catalog Number:
    10-2741
  • T-10418 | G2A agonist
    CAS:
    1608784-68-4
    Catalog Number:
    10-4916
  • CBA | TRPM4 blocker
    CAS:
    351424-20-9
    Catalog Number:
    10-3643
  • PBMC·HCl | TRPM8 blocker
    CAS:
    1352138-54-5 (free base)
    Catalog Number:
    10-5707
    Activity:
    TRPM8 blocker
    Chemical Name:
    (S)-1-Phenylethyl(2-aminoethyl)(4-(benzyloxy)-3-methoxybenzyl)carbamate hydrochloride
    Molecular Weight:
    471.00
    Molecular Formula:
    C26H30N2O4·HCl
    Solubility:
    Soluble in DMSO (up to 30 mg/ml); water (10 mg/ml).
    Physical Properties:
    Off-white to pale yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • GFB-8438 | Selective TRPC5 inhibitor
    CAS:
    2304549-73-1
    Catalog Number:
    10-4270
View All TRP Products

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