CANCER
Immunology
Stem Cells
Cell Death
Neurodegeneration
Cellular Stress
Inflammation
Proteasome
Diabetes
View All Physiological Processes & Diseases
Diabetes is a disease characterized by either the inability to produce enough insulin or a lack of cellular response to insulin. The resulting high blood sugar levels lead to myriad health issues including cardiovascular disease, vision loss, nerve damage, and kidney disease. Current therapies for glycemic control include metformin, sulfonylureas and PPAR-γ agonists. Newer modalities targeting the incretin axis include dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) agonists. A novel method for controlling glucose via the kidneys is inhibition of sodium glucose co-transporter 2 (SGLT2).
Adipogenesis
A-769662
Potent and reversible AMPK allosteric activator that inhibits fatty acid biosynthesis
Fatostatin
Fatostatin blocks adipogenesis by inhibiting the activation of SREBP
GSK
Alsterpaullone
Alsterpaullone is a potent inhibitor of GSK-3β
CHIR-99021
Potent and selective inhibitor of GSK-3β
SB-216763
Potent and selective inhibitor of GSK-3α/β
AMPK
Dorsomorphin
Potent and selective inhibitor of AMPK
AICAR
AICAR is an activator of AMPK
Metformin
Inhibits gluconeogenesis by activating the AMPK pathway
PPAR
Rosiglitazone maleate
Clinically useful PPARγ agonist
Pioglitazone HCl
Clinically useful PPARγ agonist
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