Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
VIEW ALL BIOCHEMICAL TARGETS
Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.
Glucose
2-NBD-Glucose
Fluorescent glucose uptake probe
SR9243
LXR inverse agonist that reduces glycolytic and lipogenic gene expression
Koningic acid
Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase
Glutamine
CB-839
Potent and selective inhibitor of glutaminase (KGA and GAC)
R162
Selective inhibitor of glutamate dehydrogenase 1(GDH1)
Complex Carbohydrates
Thiamet G
Thiamet G is a potent and selective inhibitor of O-GlcNAcase
NGI-1
NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)
Kifunensine
Inhibits glycoprotein processing via inhibition of class I a-mannosidases
Lipid
FSG67
Inhibitor of glycerol-3-phosphate acyltransferase
MF-438
A potent inhibitor of stearoyl-CoA desaturase 1
BMS-303141
ATP citrate lyase (ACL) inhibitor
Polyamine
Mitoguazone 2HCl
Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)
POB
Pro-drug inhibitor of ornithine decarboxylase
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