Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

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Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.

Home >> Cellular Metabolism

Glucose

2-NBD-Glucose

Fluorescent glucose uptake probe

SR9243

LXR inverse agonist that reduces glycolytic and lipogenic gene expression

Koningic acid

Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase

Glutamine

CB-839

Potent and selective inhibitor of glutaminase (KGA and GAC)

R162

Selective inhibitor of glutamate dehydrogenase 1(GDH1)

Complex Carbohydrates

Thiamet G

Thiamet G is a potent and selective inhibitor of O-GlcNAcase

NGI-1

NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)

Kifunensine

Inhibits glycoprotein processing via inhibition of class I a-mannosidases

Lipid

FSG67

Inhibitor of glycerol-3-phosphate acyltransferase

MF-438

A potent inhibitor of stearoyl-CoA desaturase 1

BMS-303141

ATP citrate lyase (ACL) inhibitor

Polyamine

Mitoguazone 2HCl

Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)

POB

Pro-drug inhibitor of ornithine decarboxylase

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Focus Biomolecules at ASCB Cell Biology

Focus will be exhibiting at ASCB Cell Biology, Dec 3-7 in Washington DC. Stop by our booth #2205 and chat with our scientists! Learn about our new...

Filipin III for Cholesterol Research

Filipin III is a microbial natural product isolated from Streptomyces filipinensis. It is an important fluorescent probe for cellular cholesterol...

Sinefungin in Antiviral Research

Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces...

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