CANCER

Immunology

Stem Cells

Cell Death

Neurodegeneration

Cellular Stress

Inflammation

Proteasome

Diabetes

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Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.

DNA damage

Rucaparib phosphate

Rucaparib is a potent PARP1 inhibitor

RI-1

RI-1 is a selective inhibitor of RAD51

Lomeguatrib

Lomeguatrib is a potent inhibitor of the DNA methyltransferase MGMT

Mirin

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex

Heat shock proteins

Radicicol

Inhibits HSP90 by binding to the ATP-binding pocket

17-DMAG

17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines

Teprenone

Teprenone is an inducer of HSP70

Compound 115-7c

KArtificial co-chaperone for HSP70

Autophagy

3-Methyladenine

Inhibits autophagy by blocking autophagosome formation

Bafilomycin A1

Bafilomycin A1 inhibits autophagy by disrupting the fusion between autophagosomes and lysosomes

Seriniquinone

Induces autophagy via targeting of dermicidin

Ophiobolin A

Ophiobolin A is a natural product that induces autophagy

SMER-28

SMER-28 induces autophagy by an mTOR-independent pathway

Reactive oxygen species

Bakuchiol

Bakuchiol is a natural terpenoid antioxidant

Carnosic acid

Carnosic acid is an antioxidant and free radical scavenger

DMNQ

DMNQ is non-alkylating redox cycling quinone useful for studying ROS and oxidative stress

L-Ergothioneine

L-Ergothioneine is an endogenous antioxidant

Unfolded protein response

Azoramide

Azoramide improve ER folding and activates ER chaperone capacity

Toyocamycin

Toyocamycin inhibits the unfolded protein response

4m8C

Inhibits the unfolded protein response via inhibition of IRE1 ribonuclease

STF-083010

STF-083010 inhibits IRE1 endonuclease activity

ER Stress

TUDCA

TUDCA is a classic inhibitor of ER stress

Patulin

Patulin induces apoptosis through an ROS-mediated ER stress pathway

Tunicamycin

Tunicamycin causes ER stress-induced autophagy

Salubrinal

Salubrinal is an eIF2a phosphatase inhibitor that mitigates ER stress

Cellular Stress

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BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

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