Cancer

Cancer is a collection of related genetic diseases that cause cells to divide uncontrollably and spread to surrounding tissues. Phenotypic changes to cancer cells include abnormal shape, fast rate of division, high metabolic rate, and invasion of surrounding tissues. The aberrant genes that lead to cancer can arise from DNA damage caused by environmental sources, errors that occur during cell division, or inherited. Tumor promoting genetic mutations occur in oncogenes that activate pathways related to cell proliferation or inactivate cell death pathways. Mutations in tumor suppressor genes lead to loss of function in growth inhibition, DNA damage repair, and apoptosis activation pathways.

Angiogenesis

  • Bortezomib | Proteasome inhibitor
    CAS:
    179324-69-7
    Catalog Number:
    10-2120
    Activity:
    Proteasome inhibitor
    Alternate Names:
    MG-341, PS-341
    Chemical Name:
    N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
    Molecular Weight:
    384.25
    Molecular Formula:
    C19H25BN4O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Cediranib | VEGFR inhibitor
    CAS:
    288383-20-0
    Catalog Number:
    10-4142
  • E7820 | RBM39 molecular glue
    CAS:
    289483-69-8
    Catalog Number:
    10-3935
  • ABT-869 | Dual VEGFR and PDGFR kinase inhibitor
    CAS:
    796967-16-3
    Catalog Number:
    10-5268
  • Vandetanib | VEGFR2 inhibitor
    CAS:
    443913-73-3
    Catalog Number:
    10-2185
    Activity:
    VEGFR2 inhibitor
    Chemical Names:
    4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
    Alternate Name:
    ZD6474
    Molecular Weight:
    475.35
    Molecular Formula:
    C22H24BrFN4O2
    Solubility:
    Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Angiogenesis Products

Autophagy

  • GNS561 | PPT1 inhibitor/STING activator
    CAS:
    1914148-73-4
    Catalog Number:
    10-4138
  • PF-543 HCl | Sphingosine kinase-1 inhibitor
    CAS:
    1706522-79-3
    Catalog Number:
    10-4998
  • Vacuolin-1 | Autophagy/PIKfyve inhibitor
    CAS:
    351986-85-1
    Catalog Number:
    10-5151
  • Verteporfin | YAP Inhibitor
    CAS:
    129497-78-5
    Catalog Number:
    10-3487
    Activity:
    YAP inhibitor
    Chemical Names:
    (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
    Alternate Name:
    CL 318,952; BPD-MA
    Molecular Weight:
    718.79
    Molecular Formula:
    C41H42N4O8
    Solubility:
    Soluble in DMSO (up to 14 mg/ml)
    Physical Properties:
    Black solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Torin1 | mTOR inhibitor
    CAS:
    1222998-36-8
    Catalog Number:
    10-3013
    Activity:
    mTOR inhibitor
    Chemical Name:
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
    Molecular Weight:
    607.62
    Molecular Formula:
    C35H28F3N5O2
    Solubility:
    Soluble in DMSO (up to 8 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Autophagy Products

Cancer Cell Metabolism

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Cancer Stem Cells

  • Compound E | gamma-secretase inhibitor
    CAS:
    209986-17-4
    Catalog Number:
    10-3479
  • STF-118804 | NAMPT inhibitor
    CAS:
    894187-61-2
    Catalog Number:
    10-5640
  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • Sulconazole | Antifungal/ Prevents cancer stem cell formation
    CAS:
    61318-91-0
    Catalog Number:
    10-3955
    Activity:
    Antifungal/Prevents cancer stem cell formation
    Chemical Names:
    1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
    Molecular Weight:
    460.75
    Molecular Formula:
    C18H15Cl3N2S·HNO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Nitisinone | Tyrosine metabolism inhibitor
    CAS:
    104206-65-7
    Catalog Number:
    10-4648
    Activity:
    Tyrosine metabolism inhibitor
    Chemical Names:
    2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
    Alternate Name:
    NTBC
    Molecular Weight:
    329.23
    Molecular Formula:
    C14H10F3NO5
    Solubility:
    Soluble in DMSO (at least 70 mg/ml); ethanol (10 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Cancer Stem Cells Products

Cell Cycle

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Cellular Stress

  • AZD7648 | DNA-PK inhibitor/CRISPR enhancer
    CAS:
    2230820-11-6
    Catalog Number:
    10-4108
  • MitoBloCK-10 | TIMM44 blocker
    CAS:
    394694-98-5
    Catalog Number:
    10-5324
  • Honokiol-DCA | TRAP1 Inhibitor
    CAS:
    1620160-42-0
    Catalog Number:
    10-3596
  • Luminespib | HSP90 inhibitor
    CAS:
    747412-49-3
    Catalog Number:
    10-4672
    Activity:
    HSP90 inhibitor
    Chemical Names:
    5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
    Alternate Name:
    NVP-AUY922; VER-52296
    Molecular Weight:
    465.54
    Molecular Formula:
    C26H31N3O5
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Cellular Stress Products

Chemotherapeutics

  • Capivasertib | pan-AKT inhibitor
    CAS:
    1143532-39-1
    Catalog Number:
    10-4383
  • Actinomycin D | Transcription inhibitor
    CAS:
    50-76-0
    Catalog Number:
    10-2054
    Activity:
    Transcription inhibitor
    Molecular Weight:
    1255.42
    Molecular Formula:
    C62H86N12O16
    Solubility:
    Soluble in DMSO (50 mg/ml).
    Physical Properties:
    Orange-red solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
    Shipping Code:
    RT
  • Bortezomib | Proteasome inhibitor
    CAS:
    179324-69-7
    Catalog Number:
    10-2120
    Activity:
    Proteasome inhibitor
    Alternate Names:
    MG-341, PS-341
    Chemical Name:
    N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
    Molecular Weight:
    384.25
    Molecular Formula:
    C19H25BN4O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • SAHA | HDAC inhibitor
    CAS:
    149647-78-9
    Catalog Number:
    10-1067
    Activity:
    HDAC inhibitor
    Alternate Names:
    Vorinostat
    Chemical Name:
    Suberoylanilide-hydroxamic acid
    Molecular Weight:
    264.33
    Molecular Formula:
    C14H20N2O3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
    Shipping Code:
    RT
  • Methotrexate | Dihydrofolate reductase inhibitor
    CAS:
    133073-73-1
    Catalog Number:
    10-1260
    Activity:
    Dihydrofolate reductase inhibitor
    Chemical Names:
    N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740
    Molecular Weight:
    683.63
    Molecular Formula:
    C20H22N8O5·XH2O
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Chemotherapeutics Products

Chimeric Antigen Receptor Cells

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Cytoskeleton

  • UR214-9 | Septin inhibitor
    CAS:
    2456263-31-1
    Catalog Number:
    10-4397
  • RGN6024 | Tubulin destabilizer
    CAS:
    3055038-20-2
    Catalog Number:
    10-4227
  • Colchicine | Microtubule depolymerizer
    CAS:
    64-86-8
    Catalog Number:
    10-2310
    Activity:
    Microtubule depolymerizing agent
    Chemical Name:
    (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
    Molecular Weight:
    399.45
    Molecular Formula:
    C22H25NO6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml), in Water (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White to pale-yellow solid
    Purity:
    99% by TLC/HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Dynarrestin | Cytoplasmic dynein 1/2 inhibitor
    CAS:
    2222768-84-3
    Catalog Number:
    10-4196
  • Cytochalasin B | Actin filament disrupting agent
    CAS:
    14930-96-2
    Catalog Number:
    10-2069
    Activity:
    Actin filament disrupting agent
    Fermentation product:
    from Drechslera dematioidea
    Alternate Name:
    NSC107658; Phominone
    Molecular Weight:
    479.61
    Molecular Formula:
    C29H37NO5
    Solubility:
    Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Cytoskeleton Products

DNA Damage/Repair

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Drug resistance

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Epigenetics

  • Tucidinostat | Class I HDAC inhibitor
    CAS:
    1616493-44-7
    Catalog Number:
    10-4404
  • DC2-C1 | YTHDC2 inhibitor
    CAS:
    N/A
    Catalog Number:
    10-4889
  • AZ1 | USP25/28 inhibitor
    CAS:
    2165322-94-9
    Catalog Number:
    10-4317
  • Trichostatin A | HDAC inhibitor
    CAS:
    58880-19-6
    Catalog Number:
    10-2110
    Activity:
    HDAC inhibitor
    Alternate Names:
    TSA
    Chemical Name:
    (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    Molecular Weight:
    302.38
    Molecular Formula:
    C17H22N2O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 3 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • DC-Y13-27 | YTHDF2 inhibitor
    CAS:
    3069691-93-6
    Catalog Number:
    10-4884
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Gene Regulation/Transcription

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Growth factors

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Immuno-oncology

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Kinases

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Metastasis

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Other Cancer

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p53 & Other Tumor Suppressors

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Programmed cell death

  • Violacein | Immunostimulant
    CAS:
    548-54-9
    Catalog Number:
    10-5073
  • Geranylgeranoic acid | Bioactive Isoprenoid
    CAS:
    35750-48-2
    Catalog Number:
    10-3337
  • BMS-1166 | PD-1/PD-L1 inhibitor
    CAS:
    1818314-88-3
    Catalog Number:
    10-4903
  • Bortezomib | Proteasome inhibitor
    CAS:
    179324-69-7
    Catalog Number:
    10-2120
    Activity:
    Proteasome inhibitor
    Alternate Names:
    MG-341, PS-341
    Chemical Name:
    N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
    Molecular Weight:
    384.25
    Molecular Formula:
    C19H25BN4O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Brefeldin A | Inhibits intracellular transport
    CAS:
    20350-15-6
    Catalog Number:
    10-1071
    Activity:
    Inhibits intracellular transport
    Alternate Names:
    Fermentation product from Penicillium brefeldianum
    Molecular Weight:
    280.37
    Molecular Formula:
    C16H24O4
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Programmed cell death Products

Stem Cells

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Tumor Microenvironment

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Ubiquitin proteasome

  • Ixazomib | Proteasome inhibitor
    CAS:
    1072833-77-2
    Catalog Number:
    10-5185
  • MS102 | USP2 inhibitor
    CAS:
    N/A
    Catalog Number:
    10-4937
  • AZ1 | USP25/28 inhibitor
    CAS:
    2165322-94-9
    Catalog Number:
    10-4317
  • Bortezomib | Proteasome inhibitor
    CAS:
    179324-69-7
    Catalog Number:
    10-2120
    Activity:
    Proteasome inhibitor
    Alternate Names:
    MG-341, PS-341
    Chemical Name:
    N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
    Molecular Weight:
    384.25
    Molecular Formula:
    C19H25BN4O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ARV-110 | Androgen receptor degrader
    CAS:
    2222112-77-6
    Catalog Number:
    10-3016
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Wnt/ß-Catenin

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