CANCER

Immunology

Stem Cells

Cell Death

Neurodegeneration

Cellular Stress

Inflammation

Proteasome

Diabetes

View All Physiological Processes & Diseases

Cancer is a collection of related genetic diseases that cause cells to divide uncontrollably and spread to surrounding tissues. Phenotypic changes to cancer cells include abnormal shape, fast rate of division, high metabolic rate, and invasion of surrounding tissues. The aberrant genes that lead to cancer can arise from DNA damage caused by environmental sources, errors that occur during cell division, or inherited. Tumor promoting genetic mutations occur in oncogenes that activate pathways related to cell proliferation or inactivate cell death pathways. Mutations in tumor suppressor genes lead to loss of function in growth inhibition, DNA damage repair, and apoptosis activation pathways.

Cytoskeleton

Epothilone B

Epothilone B induces microtubule polymerization

Cytochalasin D

Cytochalasin D is a potent inhibitor of actin polymerization

K858

K858 is a selective mitotic kinesin Eg5 inhibitor

Kinases

R428

AXL inhibitor that suppresses myeloid cell activation

Galunisertib

TGF-β kinase inhibitor that reverses TGF-β and Treg mediated T cell suppression

RO-3306

RO-3306 is a selective inhibitor of CDK1

KU-55933

KU-55933 is a potent and selective ATM kinase inhibitor

NU7441

DNA protein kinase inhibitor

DNA Damage / Repair

Rucaparib phosphate

Rucaparib is a potent PARP1 inhibitor

RI-1

RI-1 is a selective inhibitor of RAD51

Lomeguatrib

Lomeguatrib is a potent inhibitor of the DNA methyltransferase MGMT

Mirin

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex

Epigenetics

I-BET762

I-BET762 is a potent inhibitor of the BET family of bromodomains

SP2509

SP2509 is a potent and reversible inhibitor of LSD1

CPI-455

CPI-455 is a potent and selective inhibitor of the lysine demethylase KDM5

EPZ015666

Potent and selective inhibitor of the arginine methyltransferase PRMT5

Metabolism

Koningic acid

Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase

CB-839

Potent and selective inhibitor of glutaminase (KGA and GAC)

2-NBD-Glucose

Fluorescent glucose uptake probe

Kifunensine

Kifunensine Inhibits glycoprotein processing via inhibition of class I α-mannosidases

Immunology

Epacadostat

Epacadostat is a potent and selective inhibitor of IDO1

CPI-444

CPI-444 is a potent and selective adenosine A2A antagonist

Motolimod

Selective TLR8 agonist

SHP099

SHP099 is an SHP2 phosphatase inhibitor that mediates PD-1 and CTLA immune checkpoint pathways

Cancer

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and...

REV-ERB agonists and Cancer

Researchers at the Salk Institute, the University of California, and the University of Texas have identified a potential new class of cancer...

SHP099 targets ALK inhibitor resistant cancer

Multiple cellular pathways can lead to acquired resistance to ALK inhibitors.  A common pathway is activation of alternate kinase pathways,...

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