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The human immune system is composed of two major parts, the adaptive immune system and the innate immune system. The initial reaction to a pathogen involves the innate system, a non-specific response that involves inflammation, leukocytes, and the complement system. The adaptive immune system response is carried out by B cell and T cell lymphocytes. B cells are activated to secrete antibodies to the pathogen, present antigen, and secrete cytokines and various T cells kill target cells, activate macrophages, and stimulate B cells to produce antibodies. The adaptive immune system also creates immunological memory through memory B and T cells that provide enhanced protection to future infection.

Home >> Immunology

Immunosuppressants

FK-506

FK-506 induced immunosuppression by inhibiting T cell proliferation

Mycophenolic acid

Blocks the biosynthesis of guanine nucleotides via inhibition of 5′-monophosphate dehydrogenase

Caerulomycin

Suppresses T cell activation and IFNγ secretion

Triptolide

Triptolide is a potent immunosuppressive and antiinflammatory agent

STING

H151

H151 is an inhibitor of STING in mouse and human cells

DMXAA

DMXAA is a STING agonist in mice

2′,3′-cGAMP

2′,3′-cGAMP is an endogenous agonist of STING

Chemokines

PF-4136309

PF-4136309 is a potent and selective inhibitor of CCR2

Maraviroc

Maraviroc is a potent and selective inhibitor of CCR5

Reparixin

Reparixin is an allosteric CXCR1/2 antagonist

Cancer Immunotherapy

Epacadostat

Epacadostat is a potent and selective inhibitor of IDO1

CPI-444

CPI-444 is a potent and selective adenosine A2A antagonist

Motolimod

Selective TLR8 agonist

SHP099

SHP099 is an SHP2 phosphatase inhibitor that mediates PD-1 and CTLA immune checkpoint pathways

Toll-like receptors

Motolimod

Motolimod is a selective TLR8 agonist

Resiquimod

Resiquimod is a TLR7/8 agonist

Suplatast tosilate

Suplatast suppresses innate immunity by downregulating TLR2 and TLR4

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