Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

VIEW ALL Biochemical Targets

Ion Channels are pore-forming proteins that allow the selective passage of ions through plasma or intracellular organelle membranes based on an electric gradient. In addition to transducing electrical currents in the body, they play a role in cellular signaling, pH regulation, and cell volume regulation. Ion channels can be defined by what opens and closes the channel: voltage-gated channels open and close based on the voltage gradient across the plasma membrane or ligand-gated channels by the binding of various ligands to the channel. They are also be defined by the type of ion that selectively passes through (calcium, sodium, potassium etc.) or by the physical stimulation that opens or closes them (mechanosensitive, light sensitive, or temperature sensitive). Many disease states are caused by perturbed ion channel function (channelopathies) including epilepsy, cystic fibrosis, long QT syndrome, and various musculo-skeletal disorders. Pharmacologic manipulation of ion channels is widely used to treat cardiovascular disorders, pain, diabetes, constipation and is being investigated for use in cancer, inflammation, immunomodulation, kidney diseases and infection.

Calcium

BAY K8644

L-type calcium channel activator

Niguldipine

L-type calcium channel blocker

Potassium

Cereulide

Potent ionophore with high selectivity of K+

ML-297

ML-297 is a selective GIRK1/2 channel activator

Sodium

4,9-Anydrotetrodotoxin

AnhydroTTX is a selective blocker of the Nav1.6 sodium channel

A-803467

Potent and selective blocker of the Nav1.8 channel

TRP

AC1903

AC1903 is a potent and selective TRPC5 blocker

PBMC

Potent and selective inhibitor of TRPM8 channels

GSK1702934A

GSK1702934A is a TRPC3/6 activator

Ion Channels

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

FOCUS NEWS:

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and vaccines for this new virus to halt the ongoing pandemic’s onslaught. Fortunately, the SARS-CoV-2 genome is highly...

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