Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
VIEW ALL Biochemical Targets
Ion Channels are pore-forming proteins that allow the selective passage of ions through plasma or intracellular organelle membranes based on an electric gradient. In addition to transducing electrical currents in the body, they play a role in cellular signaling, pH regulation, and cell volume regulation. Ion channels can be defined by what opens and closes the channel: voltage-gated channels open and close based on the voltage gradient across the plasma membrane or ligand-gated channels by the binding of various ligands to the channel. They are also be defined by the type of ion that selectively passes through (calcium, sodium, potassium etc.) or by the physical stimulation that opens or closes them (mechanosensitive, light sensitive, or temperature sensitive). Many disease states are caused by perturbed ion channel function (channelopathies) including epilepsy, cystic fibrosis, long QT syndrome, and various musculo-skeletal disorders. Pharmacologic manipulation of ion channels is widely used to treat cardiovascular disorders, pain, diabetes, constipation and is being investigated for use in cancer, inflammation, immunomodulation, kidney diseases and infection.
Calcium
BAY K8644
L-type calcium channel activator
Niguldipine
L-type calcium channel blocker
Potassium
Cereulide
Potent ionophore with high selectivity of K+
ML-297
ML-297 is a selective GIRK1/2 channel activator
Sodium
4,9-Anydrotetrodotoxin
AnhydroTTX is a selective blocker of the Nav1.6 sodium channel
A-803467
Potent and selective blocker of the Nav1.8 channel
TRP
AC1903
AC1903 is a potent and selective TRPC5 blocker
PBMC
Potent and selective inhibitor of TRPM8 channels
GSK1702934A
GSK1702934A is a TRPC3/6 activator
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