Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
VIEW ALL Biochemical Targets
The phosphorylation state of a biologically relevant molecule affects its activity, reactivity, and ability to interact with other molecules. The enzymes responsible for adding phosphate groups, kinases, act on many types of molecules including proteins, lipids, carbohydrates, and nucleotides. These kinases mediate multiple signal transduction pathways and are responsible for modulating many essential cellular functions including metabolism, proliferation, differentiation, and survival. Dysfunction of kinases is involved in many pathological states including cancer, neurodegeneration, inflammation, metabolic and developmental disorders, and autoimmune diseases.
Immuno-Regulatory
R428
AXL inhibitor that suppresses myeloid cell activation
Pexidartinib
Dual inhibitor of CSF1R and c-KIT; Inhibits suppression of antitumor immunity
Galunisertib
TGF-β kinase inhibitor that reverses TGF-β and Treg mediated T cell suppression
Cell Cycle / Cell Division
Ribociclib
Clinically useful inhibitor of CDK4/6
RO-3306
RO-3306 is a selective inhibitor of CDK1
Alisertib
Alisertib is a potent and selective inhibitor of Aurora A kinase
DNA Damage Response
KU-55933
KU-55933 is a potent and selective ATM kinase inhibitor
NU7441
DNA protein kinase inhibitor
AZ20
Potent and selective ATR kinase inhibitor
Metabolic
PFK15
PFK15 is a phosphofructo-2-kinase (PFKFB3) inhibitor. Antagonizes glucose and F26BP uptake
GSK2334470
GSK2334470 is a potent and selective PDK1 inhibitor.
NU7441
DNA protein kinase inhibitor
Growth Factor
Afatinib
Potent and highly selective inhibitor of EGFR and HER2
NVP-BGJ398
NVP-BGJ398 is a potent and selective-pan FGFR inhibitor
Protein Kinase C
Enzastaurin
Enzastaurin is a potent and selective PKCβ inhibitor
PMA
PKC activator
NPC-15437
Protein kinase C inhibitor which interacts with the C1 domain of PKC
25-Hydroxycholesterol
Biologically active cholesterol metabolite
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