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Cardiovascular disease encompasses a broad range of pathologies including narrow or blocked blood vessels, heart muscle and valve failure, heart arrhythmias, and hypertension.

Arrhythmia

Amiodarone

Amiodarone is a pan-specific inhibitor of phosphodiesterases

Disopyramide

Disopyramide is a clinically useful sodium channel blocker

Dofetilide

Dofetilide is a selective Kv11.1 (hERG) channel

Hypertension

Cyclothiazide

Positive allosteric modulator of AMPA receptors

Felodipine

Felodipine is a potent L-type Ca2+ channel blocker

Losartan potassium

Losartan is an angiotensin II receptor antagonist

Stem Cells

1-EBIO

Potassium channel activator that promotes cardiomyocyte differentiation

AS-8351

KDM5B histone demethylase inhibitor that helps induce cardiac reprogramming of fibroblasts

KY-02111

Wnt pathway inhibitor that promotes cardiac differentiation of human pluripotent stem cells

Atherosclerosis/Lipid metabolism

Ezetimibe

Prevents intestinal cholesterol uptake by the Niemann-Pick C1-like 1 protein

Fluvastatin Na

Clinically useful potent HMG-CoA reductase inhibitor

TMP-153

TMP-153 is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase

Heart failure and protection

Visnagin

Visnagin is natural product that protects against doxorubicin-induced cardiomyopathy

EPA free acid

Natural eicosanoid with various cardioprotective properties

Teprenone

HSP70 inducer displaying cardioprotective effects in rat model of myocardial infarction

Thrombosis

Argatroban

Argatroban is a potent and selective thrombin inhibitor

Ozagrel HCl

Ozagrel blocks platelet aggregation via inhibition of thromboxane synthetase

YM-254890

Gαaq/11 inhibitor that inhibits U46619-induced platelet aggregation

Cardiovascular

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