CANCER

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Neurodegeneration

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Inflammation

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Diabetes

View All Physiological Processes & Diseases

Cardiovascular disease encompasses a broad range of pathologies including narrow or blocked blood vessels, heart muscle and valve failure, heart arrhythmias, and hypertension.

Home >> Cardiovascular

Arrhythmia

Amiodarone

Amiodarone is a pan-specific inhibitor of phosphodiesterases

Disopyramide

Disopyramide is a clinically useful sodium channel blocker

Dofetilide

Dofetilide is a selective Kv11.1 (hERG) channel

Hypertension

Cyclothiazide

Positive allosteric modulator of AMPA receptors

Felodipine

Felodipine is a potent L-type Ca2+ channel blocker

Losartan potassium

Losartan is an angiotensin II receptor antagonist

Stem Cells

1-EBIO

Potassium channel activator that promotes cardiomyocyte differentiation

AS-8351

KDM5B histone demethylase inhibitor that helps induce cardiac reprogramming of fibroblasts

KY-02111

Wnt pathway inhibitor that promotes cardiac differentiation of human pluripotent stem cells

Atherosclerosis/Lipid metabolism

Ezetimibe

Prevents intestinal cholesterol uptake by the Niemann-Pick C1-like 1 protein

Fluvastatin Na

Clinically useful potent HMG-CoA reductase inhibitor

TMP-153

TMP-153 is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase

Heart failure and protection

Visnagin

Visnagin is natural product that protects against doxorubicin-induced cardiomyopathy

EPA free acid

Natural eicosanoid with various cardioprotective properties

Teprenone

HSP70 inducer displaying cardioprotective effects in rat model of myocardial infarction

Thrombosis

Argatroban

Argatroban is a potent and selective thrombin inhibitor

Ozagrel HCl

Ozagrel blocks platelet aggregation via inhibition of thromboxane synthetase

YM-254890

Gαaq/11 inhibitor that inhibits U46619-induced platelet aggregation

NEW PRODUCTS

BIOCHEMICAL TARGETS

PROCESSES AND DISEASES

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

Synthesis and Characterization of Destruxins

In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR,...

Tumor immune surveillance news

Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel...

Rare enzyme activator, Mitapivat

Mitapivat is an allosteric activator of red blood cell pyruvate kinase, the enzyme that performs the final step of glycolysis: it catalyzes the...

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