Cellular Metabolism
AUTOPHAGY
Ion & Other Channels
Epigenetics
Cytoskeleton
Kinases
Mitochondria
Nuclear Receptors
Bioactive Lipids
Ubiquitin Proteasome
View all Biochemical Targets
Bioactive lipids are a diverse group of endogenous molecules that are involved in a wide array of biological processes. Members of this family include prostaglandins, leukotrienes, sphingolipids, fatty acids and their metabolic products, steroids, phospholipids, vitamins, endocannabinoids, and acylglycerol derivatives.
Sphingolipids
Dihydrosphingosine
Biosynthetic precursor of sphingosine and an inhibitor of PKC and PLA2, PLD.
N,N-Dimethylsphingosine
Endogenous sphingolipid.
Sphingosine-1-phosphate
Endogenous sphingolipid involved in many cellular responses.
Eicosanoids
Anandamide
Anandamide is an endogenous cannabinoid receptor agonist
Prostaglandin A1
PGA1 is a naturally occurring prostaglandin with diverse biological actions
Prostaglandin E2
PGE2 is a naturally occurring prostaglandin with diverse biological actions
Lipid metabolism inhibitors
JZL-184
JZL-184 is an inhibitor of MAG lipase
JNJ-1661010
JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor
RHC-80267
RHC-80267 is a DAG lipase inhibitor
Lipid receptor agonists and antagonists
Grapiprant
Potent and selective EP4 receptor antagonist
AH-7614
AH-7614 is a selective free fatty acid receptor (FFA4) inhibitor
GRI-977143
GRI-977143 is a selective agonist of the lysophosphatidic acid 2 receptor (LPA2)
WEB-2086
WEB-2086 is a potent and selective antagonist of the platelet activating factor (PAF) receptor
Fatty acids
Erucamide
Endogenous fatty acid amide with antidepressant and antianxiety effects
Oleoylethanolamide
Endogenous anandamide-like lipid that acts as a GPR119 agonist
Lipid biosynthesis inhibitors
Cerulenin
Cerulenin inhibits fatty acid synthase by binding to b-keto-acyl-ACP synthase
Fatostatin
Fatostatin blocks fat synthesis by inhibiting the activation of SREBP
Hymeglusin
Hymeglusin is an inhibitor of HMG-CoA synthase
Myriocin
Blocks sphingolipid biosynthesis via inhibition of serine palmitoyltransferase
Cholesterol derivatives
20(S)-Hydroxycholesterol
Endogenous LXR ligand and smoothened activator
24(S),25-Epoxycholesterol
Endogenous LXR ligand. Controls cellular cholesterol homeostasis
24(S)-Hydroxycholesterol
Endogenous LXR and ROR ligand
25-Hydroxycholesterol
Biologically active cholesterol metabolite
Lipid phosphates
Sphingosine-1-phosphate
Endogenous sphingolipid involved in many cellular responses
Lysophosphatidic acid (Oleoyl)
Endogenous LPA receptor agonist
Phosphatidyl ethanol
Endogenous metabolite of phosphatidyl choline
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