Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

View all Biochemical Targets

Bioactive lipids are a diverse group of endogenous molecules that are involved in a wide array of biological processes. Members of this family include prostaglandins, leukotrienes, sphingolipids, fatty acids and their metabolic products, steroids, phospholipids, vitamins, endocannabinoids, and acylglycerol derivatives.

Sphingolipids

Dihydrosphingosine

Biosynthetic precursor of sphingosine and an inhibitor of PKC and PLA2, PLD.

N,N-Dimethylsphingosine

Endogenous sphingolipid.

Sphingosine-1-phosphate

Endogenous sphingolipid involved in many cellular responses.

Eicosanoids

Anandamide

Anandamide is an endogenous cannabinoid receptor agonist

Prostaglandin A1

PGA1 is a naturally occurring prostaglandin with diverse biological actions

Prostaglandin E2

PGE2 is a naturally occurring prostaglandin with diverse biological actions

Lipid metabolism inhibitors

JZL-184

JZL-184 is an inhibitor of MAG lipase

JNJ-1661010

JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor

RHC-80267

RHC-80267 is a DAG lipase inhibitor

Lipid receptor agonists and antagonists

Grapiprant

Potent and selective EP4 receptor antagonist

AH-7614

AH-7614 is a selective free fatty acid receptor (FFA4) inhibitor

GRI-977143

GRI-977143 is a selective agonist of the lysophosphatidic acid 2 receptor (LPA2)

WEB-2086

WEB-2086 is a potent and selective antagonist of the platelet activating factor (PAF) receptor

Fatty acids

Erucamide

Endogenous fatty acid amide with antidepressant and antianxiety effects

Oleoylethanolamide

Endogenous anandamide-like lipid that acts as a GPR119 agonist

Lipid biosynthesis inhibitors

Cerulenin

Cerulenin inhibits fatty acid synthase by binding to b-keto-acyl-ACP synthase

Fatostatin

Fatostatin blocks fat synthesis by inhibiting the activation of SREBP

Hymeglusin

Hymeglusin is an inhibitor of HMG-CoA synthase

Myriocin

Blocks sphingolipid biosynthesis via inhibition of serine palmitoyltransferase

Cholesterol derivatives

20(S)-Hydroxycholesterol

Endogenous LXR ligand and smoothened activator

24(S),25-Epoxycholesterol

Endogenous LXR ligand. Controls cellular cholesterol homeostasis

24(S)-Hydroxycholesterol

Endogenous LXR and ROR ligand

25-Hydroxycholesterol

Biologically active cholesterol metabolite

Lipid phosphates

Sphingosine-1-phosphate

Endogenous sphingolipid involved in many cellular responses

Lysophosphatidic acid (Oleoyl)

Endogenous LPA receptor agonist

Phosphatidyl ethanol

Endogenous metabolite of phosphatidyl choline

Bioactive Lipids

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

FOCUS NEWS:

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