Cellular Metabolism

AUTOPHAGY

Ion & Other Channels

Epigenetics

Cytoskeleton

Kinases

Mitochondria

Nuclear Receptors

Bioactive Lipids

Ubiquitin Proteasome

View all Biochemical Targets

Nuclear receptors are ligand-gated transcription factors that regulate various physiological processes such as reproduction, inflammation, metabolism, development, and immune function. The 48 human nuclear receptors are controlled by lipophilic signaling molecules: endocrine nuclear receptors bind various steroid hormones, thyroid hormone, or the biologically active forms of vitamins A and D and retinoic acid, adopted orphan nuclear receptors bind to various lipids, metabolic intermediates, or xenobiotics, and orphan receptors have no known endogenous ligand but still operate as transcription factors. Because of their ability to directly interact with and control DNA expression, they play a significant role in cancer, diabetes, immune disorders, and other pathologies.

AhR

Kynurenine

Endogenous ligand of the human arylhydrocarbon receptor

CH-223191

CH-223191 is a potent arylhydrocarbon receptor antagonist

6-Formylindolo[3,2-b]carbazole

Ultrapotent arylhydrocarbon receptor agonist

LXR

24(S),25-Epoxycholesterol

Endogenous ligand for LXR

5α, 6α-Epoxycholesterol

Endogenous ligand for LXR

SR9243

SR9243 is an LXR inverse agonist that reduces glycolytic and lipogenic gene expression

RAR

Adapalene

Stable retinoic acid analog that acts as a selective RARβ and RARγ agonist.

Ro 41-5253

Ro 41-5253 is a selective RARα antagonist

PPAR

GW-501516

GW-501516 is a potent and selective PPARδ agonist

Rosiglitazone maleate

Potent and selective PPARγ agonist

WY-14643

WY-14643 is a selective PPARα agonist

ROR

SR1001

SR1001 is an inverse agonist for both RORα and RORγt.

SR0987

SR0987 is an RORγt agonist that drives proliferation of Th17 cells ansd decreases PD-1 levels

Nuclear Receptors

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

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