Intelliscreen™ DNA Damage Inducers Mini-Library
DNA damage-inducing agents have been a cornerstone of cancer treatment for decades. DNA damage of cancer cells can lead to inhibition of cellular proliferation and induction of cell death. The IntelliscreenTM DNA Damage Inducers mini-library contains classes of agents including alkylating/platinum-based reagents that directly interact with DNA, antimetabolites that interfere with DNA replication and repair, topoisomerase inhibitors, and antitumor antibiotics which function through a variety of mechanisms including intercalation, alkylation, and ROS production.
Catalog Number:
10-7330
Description:
25 compounds that induce DNA damage via different mechanisms
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$ 600.00
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
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2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
From $50.00CAS:10356-76-0Catalog Number:10-2685Activity:Irreversible DNA methyl transferase inhibitorAlternate Names:FCDR; NSC-48006; FdCydChemical Name:5-Fluoro-2’deoxycytidineMolecular Weight:245.21Molecular Formula:C9H12FN3O4Solubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
4-NDQ | Forms stable adducts with purine bases
CAS:56-57-5Catalog Number:10-3747 -
5-Azacytidine | DNA hypomethylation agent
From $20.00CAS:320-67-2Catalog Number:10-1267Activity:DNA hypomethylation agentAlternate Names:Ladakamycin; U-18496; NSC-102816; AzaCChemical Name:4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-oneMolecular Weight:244.21Molecular Formula:C8H12N4O5Solubility:Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.Shipping Code:RT -
5-Ethynyl-2′-deoxyuridine | DNA labeling
From $40.00CAS:61135-33-9Catalog Number:10-2794Activity:DNA labelingAlternate Names:5-EdUChemical Name:2′-Deoxy-5-ethynyluridineMolecular Weight:252.23Molecular Formula:C11H12N2O5Solubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:White or off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.Shipping Code:RT -
Actinomycin D | Transcription inhibitor
From $60.00CAS:50-76-0Catalog Number:10-2054Activity:Transcription inhibitorMolecular Weight:1255.42Molecular Formula:C62H86N12O16Solubility:Soluble in DMSO (50 mg/ml).Physical Properties:Orange-red solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.Shipping Code:RT -
Azaserine | Inhibits purine biosynthesis
CAS:115-02-6Catalog Number:10-4707 -
Bleomycin sulfate | Induces double strand DNA breaks
From $75.00CAS:9041-93-4Catalog Number:10-2623Activity:Fibrosis-inducing agentSource:From Streptomyces verticillusMolecular Weight:1512.62Molecular Formula:C55H85N17O25S4Solubility:Soluble in Water (up to 20 mg/ml)Physical Properties:White or off-white solidPurity:Contains a mixture of A2 (~70%) and B2 (~30%) forms
95% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
Camptothecin | Topoisomerase I inhibitor
From $40.00CAS:7689-03-4Catalog Number:10-1041Activity:Topoisomerase I inhibitorChemical Name:(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dioneMolecular Weight:348.35Molecular Formula:C20H16N2O4Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Tan solidPurity:98%Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Cisplatin | Anticancer agent
From $50.00CAS:15663-27-1Catalog Number:10-2204Activity:Anticancer agentChemical Name:Cis-DiaminodichloroplatinumAlternate Names:CDDP; cis-Diamineplatinum(II) dichlorideMolecular Weight:300.05Molecular Formula:Cl2H4N2PtSolubility:Soluble in Water (up to 2.5 mg/ml with warming)Physical Properties:Yellow solidPurity:98% by HPLC
Elemental Analysis (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water are not stable and must be used within 1 working day. do not store solutions.Shipping Code:RT -
Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
From $60.00CAS:23541-50-6Catalog Number:10-2429Activity:DNA Damaging Agent / Anticancer agentAlternate Names:Daunomycin; rubidomycin; RP-13057Molecular Weight:536.98Molecular Formula:C27H39NO10 • HClSolubility:Soluble in water (up to 25 mg/ml)Physical Properties:Red solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
Decitabine | DNA hypomethylation agent
From $60.00CAS:2353-33-5Catalog Number:10-2412Activity:DNA hypomethylation agentAlternate Names:NSC-127716Chemical Name:5-Aza-2′-deoxycytidineMolecular Weight:228.21Molecular Formula:C8H12N4O4Solubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 11 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.Shipping Code:RT -
Doxorubicin HCl | DNA damaging agent
From $50.00CAS:25316-40-9Catalog Number:10-2130Activity:DNA damaging agentAlternate Names:Adriamycin; NSC-123127Molecular Weight:579.99Molecular Formula:C27H29NO11 HClSolubility:Soluble in Water (up to 25 mg/ml).Physical Properties:Red-orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.Shipping Code:RT -
Epirubicin HCl | DNA damaging agent
From $48.00CAS:56390-09-1Catalog Number:10-2761Activity:DNA damaging agentChemical Name:4′-EpidoxorubicinMolecular Weight:579.99Molecular Formula:C27H29NO11 HClSolubility:Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).Physical Properties:Red orange solidPurity:97% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.Shipping Code:RT -
Etoposide | Topoisomerase II inhibitor
From $50.00CAS:33419-42-0Catalog Number:10-1123Activity:Topoisomerase II inhibitorChemical Name:4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-ß-D-glucopyranosideMolecular Weight:588.56Molecular Formula:C29H32O13Solubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
Fludarabine | DNA biosynthesis inhibitor
From $45.00CAS:21679-14-1Catalog Number:10-5047Activity:DNA synthesis inhibitorChemical Names:9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218Molecular Weight:285.23Molecular Formula:C10H12FN5O4Solubility:Soluble in DMSO (30 mg/ml)Physical Properties:White solidPurity:98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Gemcitabine HCl | DNA polymerase inhibitor
From $40.00CAS:122111-03-9Catalog Number:10-2140Activity:DNA polymerase inhibitorAlternate Names:dFdCChemical Name:2′-Deoxy-2′,2′-difluorocytidine hydrochlorideMolecular Weight:299.66Molecular Formula:C9H11F2N3O4 HClSolubility:Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).Physical Properties:White solidPurity:98%Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.Shipping Code:RT -
IMT1 | Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
CAS:2304621-31-4Catalog Number:10-3918 -
Melphalan | DNA alkylating agent
CAS:148-82-3Catalog Number:10-3302 -
Methotrexate | Dihydrofolate reductase inhibitor
From $50.00CAS:133073-73-1Catalog Number:10-1260Activity:Dihydrofolate reductase inhibitorChemical Names:N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740Molecular Weight:683.63Molecular Formula:C20H22N8O5·XH2OSolubility:Soluble in DMSO (45 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Mitomycin C | DNA crosslinking and damaging agent
From $55.00CAS:50-07-7Catalog Number:10-1170Activity:DNA crosslinking and damaging agentChemical Name:Natural fermentation product from Streptomyces sp.Molecular Weight:334.33Molecular Formula:C15H18N4O5Solubility:Soluble in DMSO (up to 15 mg/ml) or in Water (up to 1 mg/ml).Physical Properties:Blue-violet solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Storing aqueous solutions is not recommended.Shipping Code:RT -
Mitoxantrone | Topoisomerase II inhibitor
CAS:65271-80-9Catalog Number:10-2811 -
SN-38 | DNA topoisomerase I inhibitor
From $75.00CAS:86639-52-3Catalog Number:10-2425Activity:DNA topoisomerase I inhibitorChemical Name:7-Ethyl-10-hydroxycamptothecinMolecular Weight:392.41Molecular Formula:C22H20N2O5Solubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
ß-Lapachone | Topoisomerase-1 inhibitor
From $52.00CAS:4707-32-8Catalog Number:10-2386Activity:Topoisomerase I inhibitorChemical Name:3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dioneAlternate Name:NSC-26326Molecular Weight:242.27Molecular Formula:C15H14O3Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Temozolomide | Autophagy inducer
From $75.00CAS:85622-93-1Catalog Number:10-2390Activity:Autophagy inducerAlternate Names:NSC-362856Chemical Name:8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-oneMolecular Weight:194.15Molecular Formula:C6H6N6O2Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Tirapazamine | Induces single or double strand breaks
CAS:27314-97-2Catalog Number:10-3802
