Inflammation

Acute inflammation is an immune response to a pathogen, irritant, or injury to remove whatever has caused the response, dispose of damaged tissue, and initiate healing. Resident immune cells at the site of insult recognize pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS) and release various inflammatory mediators. Initial responses include vasodilation, increased vascular permeability, and extravasation of leukocytes. Mediators of inflammation include bradykinins, the complement system, cytokines, chemokines, leukotrienes, and prostaglandins among others. Chronic inflammation is characterized by infiltration of the tissue site by macrophages and lymphocytes leading to overall tissue damage. Chronic inflammatory diseases include diabetes, cardiovascular diseases, arthritis, allergies, cancer, and chronic obstructive pulmonary disease.

COX

  • SC-560 | Selective COX-1 inhibitor
    CAS:
    18817-13-2
    Catalog Number:
    10-2531
    Activity:
    Selective COX-1 inhibitor
    Chemical Name:
    5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
    Molecular Weight:
    352.74
    Molecular Formula:
    C17H12ClF3N2O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
    Physical Properties:
    Brown solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Rofecoxib | Selective COX-2 inhibitor
    CAS:
    162011-90-7
    Catalog Number:
    10-2440
    Activity:
    Selective COX-2 inhibitor
    Alternate Names:
    MK-966
    Chemical Name:
    4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
    Molecular Weight:
    314.36
    Molecular Formula:
    C17H14O4S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Sulindac Sulfide | NFkappaB inhibitor
    CAS:
    49627-27-2
    Catalog Number:
    10-2156
    Activity:
    NFkappaB inhibitor
    Chemical Name:
    (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
    Molecular Weight:
    340.42
    Molecular Formula:
    C20H17FO2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Celecoxib | COX II inhibitor
    CAS:
    169590-42-5
    Catalog Number:
    10-2124
    Activity:
    COX II inhibitor
    Alternate Names:
    SC-58635
    Chemical Name:
    4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
    Molecular Weight:
    381.38
    Molecular Formula:
    C17H14F3N3O2S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Oxaprozin | NFkB inhibitor
    CAS:
    21256-18-8
    Catalog Number:
    10-1128
    Activity:
    NFκB inhibitor
    Chemical Name:
    4,5-Diphenyl-2-oxazolepropanoic acid
    Molecular Weight:
    293.32
    Molecular Formula:
    C18H15NO3
    Solubility:
    Soluble in DMSO
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All COX Products

Cytokines

  • GAT2711 | α9 nAChR agonist
    CAS:
    N/A
    Catalog Number:
    10-4330
  • CDDO-Me | Nrf2 activator
    CAS:
    218600-53-4
    Catalog Number:
    10-5449
    Activity:
    Nrf2 activator
    Chemical Names:
    2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
    Alternate Name:
    Bardoxolone methyl; NSC-713200; RTA 402; TP-155
    Molecular Weight:
    505.70
    Molecular Formula:
    C32H43NO4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • GSK4112 | Rev-Erbα agonist
    CAS:
    1216744-19-2
    Catalog Number:
    10-5493
    Activity:
    Rev-Erbα agonist
    Chemical Names:
    N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester
    Alternate Name:
    SR6452
    Molecular Weight:
    396.89
    Molecular Formula:
    C18H21ClN2O4S
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • (5Z)-7-Oxozeaenol | TAK1 inhibitor
    CAS:
    253863-19-3
    Catalog Number:
    10-3023
    Activity:
    TAK1 inhibitor
    Chemical Names:
    (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
    Alternate Name:
    LL-Z-1640-2
    Molecular Weight:
    362.38
    Molecular Formula:
    C19H22O7
    Solubility:
    Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • NS1209 | AMPA antagonist
    CAS:
    245063-59-6
    Catalog Number:
    10-3934
View All Cytokines Products

Glucocorticoid receptors

  • Dexamethasone | Apoptosis inducing glucocorticoid
    CAS:
    50-02-2
    Catalog Number:
    10-1134
    Activity:
    Apoptosis inducing glucocorticoid
    Chemical Name:
    (11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    Molecular Weight:
    392.46
    Molecular Formula:
    C22H29FO5
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
View All Glucocorticoid receptors Products

Inflammasome

  • Muscone | Cardioprotective and neuroprotective agent
    CAS:
    541-91-3
    Catalog Number:
    10-2757
  • ML365 | Potent and selective K2P3.1 blocker
    CAS:
    947914-18-3
    Catalog Number:
    10-4658
  • Probucol | Antioxidant hypercholesterolemic agent
    CAS:
    23288-49-5
    Catalog Number:
    10-2679
  • WNK463 | pan-WNK kinase inhibitor
    CAS:
    2012607-27-9
    Catalog Number:
    10-4109
    Activity:
    pan-WNK kinase inhibitor
    Chemical Names:
    N-tert-Butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridine-2-yl]piperidin-4-yl]imidazole-4-carboxamide
    Molecular Weight:
    463.47
    Molecular Formula:
    C21H24F3N7O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Urolithin A | Mitophagy Inducer
    CAS:
    1143-70-0
    Catalog Number:
    10-3722
    Activity:
    Mitophagy inducer
    Chemical Names:
    3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; 2′,7-Dihydroxy-3,4-benzocoumarin
    Molecular Weight:
    228.20
    Molecular Formula:
    C13H8O4
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Inflammasome Products

Leukotriene Receptors

  • Gliotoxin | Immunomodulator
    CAS:
    67-99-2
    Catalog Number:
    10-2076
    Activity:
    Immunomodulator
    Chemical Names:

    (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
    [1,2-a]indole-1,4-dione; Aspergillin

    Molecular Weight:
    326.39
    Molecular Formula:
    C13H14N2O4S2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    White lyophilized solid
    Purity:
    98%  HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    CAS:
    103177-37-3
    Catalog Number:
    10-2441
    Activity:
    Leukotriene CysLT1 antagonist / GRP17 antagonist
    Chemical Name:
    N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
    Alternate Names:
    ONO-1078
    Molecular Weight:
    481.51
    Molecular Formula:
    C27H23N5O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Montelukast sodium | Leukotriene antagonist and GPR17 antagonist
    CAS:
    151767-02-1
    Catalog Number:
    10-2597
    Activity:
    Leukotriene antagonist and GRP17 antagonist
    Chemical Name:
    2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
    Alternate Names:
    MK-0476
    Molecular Weight:
    608.17
    Molecular Formula:
    C35H35ClNO3S
    Solubility:
    Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
    Physical Properties:
    Solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • BML-111 | LXA agonist/anti-inflammatory
    CAS:
    78606-80-1
    Catalog Number:
    10-3202
    Activity:
    LXA agonist and anti-inflammatory
    Chemical Name:
    (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate
    Molecular Weight:
    192.21
    Molecular Formula:
    C8H16O5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Zafirlukast | HSP70 inhibitor and leukotriene antagonist
    CAS:
    107753-78-6
    Catalog Number:
    10-1100
    Activity:
    Hsp70 inhibitor
    Alternate Names:
    ICI-204219
    Molecular Weight:
    575.69
    Molecular Formula:
    C31H33N3O6S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White or pink solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Leukotriene Receptors Products

Lipoxygenase

  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells
    CAS:
    491-67-8
    Catalog Number:
    10-2773
    Activity:
    Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Chemical Name:
    5,6,7-Trihydroxyflavone
    Molecular Weight:
    270.24
    Molecular Formula:
    C15H10O5
    Physical Properties:
    Yellow or yellow-green solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
    Shipping Code:
    RT
  • EPA free acid | omega-3 fatty acid
    CAS:
    10417-94-4
    Catalog Number:
    10-1313
    Activity:
    omega-3 fatty acid
    Alternate Names:
    Eicosapentaenoic acid
    Chemical Name:
    Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic acid (20:5, n-3)
    Molecular Weight:
    302.46
    Molecular Formula:
    C20H30O2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 100 mg/ml).
    Physical Properties:
    Colorless to pale yellow oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months.
    Shipping Code:
    RT
  • MK-886 | FLAP inhibitor
    CAS:
    118414-82-7
    Catalog Number:
    10-1040
    Activity:
    FLAP inhibitor
    Alternate Names:
    L-663,536
    Chemical Name:
    3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
    Molecular Weight:
    472.08
    Molecular Formula:
    C27H34ClNO2S
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Lipoxygenase Products

Nf-KB

  • SP100030 | Dual NF-kB/AP-1 inhibitor
    CAS:
    154563-54-9
    Catalog Number:
    10-3996
  • ML365 | Potent and selective K2P3.1 blocker
    CAS:
    947914-18-3
    Catalog Number:
    10-4658
  • Probucol | Antioxidant hypercholesterolemic agent
    CAS:
    23288-49-5
    Catalog Number:
    10-2679
  • PD 123319 ditrifluoroacetate | Angiotensin II type II antagonist
    CAS:
    136676-91-0
    Catalog Number:
    10-4959
    Activity:
    Angiotensin II AT2 antagonist
    Chemical Names:
    (6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
    Molecular Weight:
    736.66
    Molecular Formula:
    C31H32N4O3·2CF3CO2H
    Solubility:
    Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • CDDO-Me | Nrf2 activator
    CAS:
    218600-53-4
    Catalog Number:
    10-5449
    Activity:
    Nrf2 activator
    Chemical Names:
    2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
    Alternate Name:
    Bardoxolone methyl; NSC-713200; RTA 402; TP-155
    Molecular Weight:
    505.70
    Molecular Formula:
    C32H43NO4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Nf-KB Products

NMDA receptors

  • Memantine HCl | NMDA antagonist / Anti-Alzheimer’s
    CAS:
    41100-52-1
    Catalog Number:
    10-2346
    Activity:
    NMDA antagonist / Anti-Alzheimer’s
    Chemical Name:
    3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
    Alternate Names:
    3,5-Dimethyl-tricyclo[3.3.1.13,7]decam-1-amine HCl
    Molecular Weight:
    215.76
    Molecular Formula:
    C12H21N • HCl
    Solubility:
    Soluble in Water (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • MDL29,951 | GPR17 activator
    CAS:
    130798-51-5
    Catalog Number:
    10-4537
    Activity:
    GPR17 activator
    Chemical Name:
    3-(2-Carboxy-4,6-dichloroindol-3-yl)propionic acid
    Molecular Weight:
    302.11
    Molecular Formula:
    C12H9Cl2NO4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    NMR: (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • KB-R7943 mesylate | NCX inhibitor
    CAS:
    182004-65-5
    Catalog Number:
    10-1163
    Activity:
    TRPC channel blocker
    Chemical Name:
    2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
    Molecular Weight:
    427.49
    Molecular Formula:
    C16H17N3O3S CH3SO3H
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All NMDA receptors Products

Other Inflammation

View All Other Inflammation Products

PAF

  • WEB-2086 | PAF receptor antagonist
    CAS:
    105219-56-5
    Catalog Number:
    10-1389
    Activity:
    PAF receptor antagonist
    Alternate Names:
    Apafant
    Chemical Name:
    4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
    Molecular Weight:
    455.96
    Molecular Formula:
    C22H22ClN5O2S
    Solubility:
    Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Ginkgolide B | PAF receptor antagonist
    CAS:
    15291-77-7
    Catalog Number:
    10-1080
    Activity:
    PAF antagonist
    Alternate Names:
    BN 52021
    Chemical Name:
    Natural product isolated from Ginko biloba
    Molecular Weight:
    424.41
    Molecular Formula:
    C20H24O10
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All PAF Products

Pattern recognition receptors

  • Loxoribine | TLR7 agonist
    CAS:
    121288-39-9
    Catalog Number:
    10-3780
    Activity:
    TLR7 agonist
    Chemical Name:
    7-Allyl-7,8-dihydro-8-oxoguanosine
    Alternate Name:
    RWJ-21757
    Molecular Weight:
    339.30
    Molecular Formula:
    C13H17N5O6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    96% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Allopregnanolone | GABA-A positive allosteric modulator
    CAS:
    516-54-1
    Catalog Number:
    10-3489
    Activity:
    GABA-A positive allosteric modulator
    Chemical Name:
    (3α,5α)-3-Hydroxy-pregnan-20-one
    Alternate Name:
    (3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
    Molecular Weight:
    318.49
    Molecular Formula:
    C21H34O2
    Solubility:
    Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Imiquimod | TLR7 Agonist
    CAS:
    99011-02-6
    Catalog Number:
    10-4230
    Alternate Name:
    R837
    Activity:
    TLR7 agonist
    Chemical Name:
    1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine
    Molecular Weight:
    240.30
    Molecular Formula:
    C14H16N4
    Solubility:
    Soluble in DMSO (2 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Motolimod | TLR8 agonist
    CAS:
    926927-61-9
    Catalog Number:
    10-4920
    Activity:
    TLR8 agonist/Cancer immunotherapy enhancer
    Alternate Name:
    VTX-2337
    Chemical Name:
    2-Amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-1-benzapine-4-carboxamide
    Molecular Weight:
    458.61
    Molecular Formula:
    C28H34N4O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white or pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • FPS-ZM1 | RAGE receptor antagonist
    CAS:
    945714-67-0
    Catalog Number:
    10-4616
    Activity:
    RAGE receptor antagonist
    Chemical Name:
    4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
    Molecular Weight:
    327.85
    Molecular Formula:
    C20H22ClNO
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Pattern recognition receptors Products

Prostanoid receptors & prostaglandins

  • Grapiprant | EP4 Receptor antagonist
    CAS:
    415903-37-6
    Catalog Number:
    10-4006
    Activity:
    EP4 Receptor antagonist
    Chemical Name:
    1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
    Alternate Names:
    CJ-023423; ARY-007
    Molecular Weight:
    491.61
    Molecular Formula:
    C26H29N5O3S
    Solubility:
    Soluble in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • TG 4-155 | EP2 receptor antagonist
    CAS:
    1164462-05-8
    Catalog Number:
    10-1574
    Activity:
    EP2 receptor antagonist
    Chemical Name:
    (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
    Molecular Weight:
    394.47
    Molecular Formula:
    C23H26N2O4
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Zileuton | 5-LO inhibitor
    CAS:
    111406-87-2
    Catalog Number:
    10-1098
    Activity:
    5-LO inhibitor
    Chemical Name:
    N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
    Molecular Weight:
    236.29
    Molecular Formula:
    C11H12N2O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Prostanoid receptors & prostaglandins Products

ROS

  • Auraptene | Neuroprotective / Neuritogenic agent
    CAS:
    495-02-3
    Catalog Number:
    10-2593
    Activity:
    Neuroprotective / Neuritogenic agent
    Chemical Name:
    7-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one
    Alternate Name:
    7-Geranyloxycoumarin
    Molecular Weight:
    298.36
    Molecular Formula:
    C19H22O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Bakuchiol | Antioxidant
    CAS:
    10309-37-2
    Catalog Number:
    10-3161
    Activity:
    Antioxidant
    Chemical Name:
    (S)-Bakuchiol, 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol
    Molecular Weight:
    258.42
    Molecular Formula:
    C17H22O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Colorless oil
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Pirfenidone | Antifibrotic
    CAS:
    53179-13-8
    Catalog Number:
    10-2307
    Activity:
    Antifibrotic
    Chemical Name:
    5-Methyl-1-phenyl-2(1H)-pyridinone
    Molecular Weight:
    185.23
    Molecular Formula:
    C12H11NO
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • L-Ergothioneine | Endogenous Antioxidant
    CAS:
    497-30-3
    Catalog Number:
    10-3012
    Activity:
    Antioxidant – endogenous
    Chemical Name:
    (α-S)-α-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt
    Alternate Names:
    2-Mercaptohistidine betaine; NSC-7175
    Molecular Weight:
    229.31
    Molecular Formula:
    C9H16N3O2S
    Solubility:
    Soluble in Water (up to 10 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for no more then 1 day.
    Shipping Code:
    RT
  • MCI-186 | Antioxidant
    CAS:
    89-25-8
    Catalog Number:
    10-2295
    Activity:
    Antioxidant-nonphenolic
    Alternate Names:
    Edaravone
    Chemical Name:
    3-Methyl-1-phenyl-2-pyrazolin-5-one
    Molecular Weight:
    174.2
    Molecular Formula:
    C10H10N2O
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All ROS Products

STING

  • LB244 | STING antagonist
    CAS:
    N/A
    Catalog Number:
    10-4133
  • RU.521 | cGAS Inhibitor
    CAS:
    2262452-06-0
    Catalog Number:
    10-4140
    Activity:
    cGAS Inhibitor
    Chemical Name:

    3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

    Molecular Weight:
    415.23
    Molecular Formula:
    C19H12Cl2N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • 2′,3′-cGAMP | Endogenous STING agonist
    CAS:
    1441190-66-4
    Catalog Number:
    10-1639
    Activity:
    Endogenous STING agonist
    Chemical Name:
    Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
    Alternate Name:
    2′,3’cyclic GMP-AMP
    Molecular Weight:
    718.38
    Molecular Formula:
    C20H22N10O13P2·2Na
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • DMXAA | STING agonist
    CAS:
    117570-53-3
    Catalog Number:
    10-2676
    Activity:
    STING agonist
    Chemical Name:
    5,6-Dimethylxanthenone-4-acetic acid
    Alternate Names:
    ASA404; Vadimezan
    Molecular Weight:
    282.29
    Molecular Formula:
    C17H14O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • α-Mangostin | STING agonist (human)
    CAS:
    6147-11-1
    Catalog Number:
    10-3433
    Activity:
    STING agonist (human)
    Chemical Name:
    1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
    Alternate Names:
    Mangostine; Mangostin
    Molecular Weight:
    410.46
    Molecular Formula:
    C24H26O6
    Solubility:
    Soluble in DMSO (up to 50 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All STING Products

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