Cellular Stress

Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.

Autophagy

  • Vacuolin-1 | Autophagy/PIKfyve inhibitor
    CAS:
    351986-85-1
    Catalog Number:
    10-5151
  • AR7 | Activates chaperone mediated autophagy
    CAS:
    80306-38-3
    Catalog Number:
    10-5515
    Activity:
    Activates chaperone mediated autophagy
    Chemical Names:
    7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
    Molecular Weight:
    257.72
    Molecular Formula:
    C15H12ClNO
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Pale pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • R-59022 | DAG kinase inhibitor
    CAS:
    93076-89-2
    Catalog Number:
    10-3579
    Activity:
    SGLT2 inhibitor
    Chemical Names:
    6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
    Molecular Weight:
    459.58
    Molecular Formula:
    C27H26FN3OS
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Torin1 | mTOR inhibitor
    CAS:
    1222998-36-8
    Catalog Number:
    10-3013
    Activity:
    mTOR inhibitor
    Chemical Name:
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
    Molecular Weight:
    607.62
    Molecular Formula:
    C35H28F3N5O2
    Solubility:
    Soluble in DMSO (up to 8 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Purvalanol A | CDK inhibitor
    CAS:
    212844-53-6
    Catalog Number:
    10-2868
    Activity:
    CDK Inhibitor
    Chemical Name:
    (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
    Alternate Names:
    NG-60
    Molecular Weight:
    388.89
    Molecular Formula:
    C19H25ClN6O
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    Pale green solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Autophagy Products

DNA Damage Response

  • AZD7648 | DNA-PK inhibitor/CRISPR enhancer
    CAS:
    2230820-11-6
    Catalog Number:
    10-4108
  • LD2 | PRMT9 inhibitor
    CAS:
    1134334-55-6
    Catalog Number:
    10-4872
    Activity:
    PRMT9 inhibitor
    Chemical Names:
    4-Chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole
    Molecular Weight:
    247.68
    Molecular Formula:
    C12H10ClN3O
    Solubility:
    Soluble in DMSO (at least 40 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • TH10785 | OGG1 activator
    CAS:
    1002801-51-5
    Catalog Number:
    10-5698
  • VE-821 | Potent and selective ATR inhibitor
    CAS:
    1232410-49-9
    Catalog Number:
    10-5589
    Activity:
    ATR inhibitor
    Chemical Names:
    3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
    Molecular Weight:
    368.41
    Molecular Formula:
    C18H16N4O3S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SU0268 | OGG1 inhibitor
    CAS:
    2210228-45-6
    Catalog Number:
    10-4700
    Activity:
    OGG1 Inhibitor
    Chemical Names:
    3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
    Molecular Weight:
    475.56
    Molecular Formula:
    C26H25N3O4S
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All DNA Damage Response Products

ER Stress

  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Ceapin-A7 | ATF6α/UPR inhibitor
    CAS:
    2323027-38-7
    Catalog Number:
    10-3974
    Activity:
    ATF6α/UPR inhibitor
    Chemical Names:
    N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
    Molecular Weight:
    470.33
    Molecular Formula:
    C20H12F6N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AA147 | ATF6 activator
    CAS:
    393121-74-9
    Catalog Number:
    10-3973
    Activity:
    Activator of ER stress sensing protein ATF6
    Chemical Names:
    N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide; Compound 147
    Molecular Weight:
    255.32
    Molecular Formula:
    C16H17NO2
    Solubility:
    Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
    Physical Properties:
    Beige to pale orange solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tunicamycin | ER stress inducer
    CAS:
    11089-65-9
    Catalog Number:
    10-2111
    Activity:
    ER stress inducer
    Molecular Weight:
    840.0 (Avg)
    Molecular Formula:
    C38H62N4O16 (tun. B)
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity
    CAS:
    159989-65-8
    Catalog Number:
    10-3050
    Activity:
    HIV protease inhibtior / Anticancer activity
    Chemical Name:
    (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
    Alternate Name:
    AG-1343
    Molecular Weight:
    663.88
    Molecular Formula:
    C32H45N3O4S • CH3SO3H
    Solubility:
    Soluble in DMSO (up to 70 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All ER Stress Products

Heat Shock

  • Luminespib | HSP90 inhibitor
    CAS:
    747412-49-3
    Catalog Number:
    10-4672
    Activity:
    HSP90 inhibitor
    Chemical Names:
    5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
    Alternate Name:
    NVP-AUY922; VER-52296
    Molecular Weight:
    465.54
    Molecular Formula:
    C26H31N3O5
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • CCT251236 | HSF1 inhibitor
    CAS:
    1693731-40-6
    Catalog Number:
    10-4410
    Activity:
    Heat Shock Transcription Factor 1 stress pathway inhibitor
    Chemical Names:
    N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide
    Molecular Weight:
    552.63
    Molecular Formula:
    C32H32N4O5
    Solubility:
    Soluble in DMSO (5 mg/ml)
    Physical Properties:
    Off-white/beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ganetespib | HSP90 inhibitor
    CAS:
    888216-25-9
    Catalog Number:
    10-4474
    Activity:
    HSP90 inhibitor
    Chemical Name:

    3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

    Molecular Weight:
    364.40
    Molecular Formula:
    C20H20N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Radicicol | HSP90 inhibitor
    CAS:
    12772-57-5
    Catalog Number:
    10-2102
    Activity:
    HSP90 inhibitor
    Chemical Name:
    (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
    Alternate Names:
    Monorden
    Molecular Weight:
    364.78
    Molecular Formula:
    C18H17ClO6
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 8 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Compound 115-7c | HSP70 modulator
    Catalog Number:
    10-1567
    CAS#:
    908074-72-6
    Activity:
    HSP70 modulator
    Chemical Name:
    4-(5-((Benzyloxycarbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid
    Alternate Names:
    SW02
    Molecular Weight:
    477.34
    Molecular Formula:
    C23H22Cl2N2O5
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Heat Shock Products

HSP

  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
  • KNK437 | HSP70 inhibitor
    CAS:
    218924-25-5
    Catalog Number:
    10-5561
    Activity:
    HSP70 inhibitor
    Chemical Names:
    3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
    Molecular Weight:
    245.23
    Molecular Formula:
    C13H11NO4
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BIIB021 | HSP90 Inhibitor
    CAS:
    848695-25-0
    Catalog Number:
    10-4641
    Activity:
    Potent HSP90 inhibitor
    Chemical Names:
    6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine; CNF2024
    Molecular Weight:
    318.76
    Molecular Formula:
    C14H15ClN6O
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
    Shipping Code:
    RT
  • 17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand
    Catalog Number:
    10-1577
    Activity:
    Geldanamycin affinity chromatography ligand
    Chemical Name:
    17-(6-Aminohexylamino)-17-demethoxygeldanamycin
    Alternate Names:
    AH-GDM
    Molecular Weight:
    644.80
    Molecular Formula:
    C34H52N4O8
    Solubility:
    Soluble in DMSO (up to at least 50 mg/ml)
    Physical Properties:
    Dark red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 17-PAAG | Propargyl geldanamycin click reagent
    Catalog Number:
    10-1601
    Activity:
    Propargyl geldanamysin click reagent
    Chemical Name:
    17-(Propargylamino)-17-desmethoxygeldanamycin
    Molecular Weight:
    538.67
    Molecular Formula:
    C31H41N3O8
    Solubility:
    Soluble in DMSO (up to at least 50 mg/ml) or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    Violet solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All HSP Products

Hypoxia

  • Roxadustat | Prolyl hydroxylase domain inhibitor / HIF stabilizer
    CAS:
    808118-40-3
    Catalog Number:
    10-4468
    Activity:
    Prolyl hydroxylase domain inhibitor / HIF stabilizer
    Chemical Name:
    2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
    Alternate Name:
    FG-4592
    Molecular Weight:
    352.35
    Molecular Formula:
    C19H16N2O5
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white or white solid
    Purity:
    99% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • YC-1 | Soluble guanylyl cyclase activator
    CAS:
    170632-47-0
    Catalog Number:
    10-1581
    Activity:
    Soluble guanylyl cyclase activator
    Chemical Name:
    3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
    Alternate Name:
    Lificiguat
    Molecular Weight:
    304.34
    Molecular Formula:
    C19H16N2O2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Pink solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor
    CAS:
    1227158-85-1
    Catalog Number:
    10-4910
    Activity:
    HIF-1 / Mitochondrial complex I inhibitor
    Chemical Name:
    5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
    Molecular Weight:
    525.54
    Molecular Formula:
    C26H26F3N7O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • KC7F2 | HIF-1α inhibitor
    CAS:
    927822-86-4
    Catalog Number:
    10-4714
    Activity:
    HIF-1alpha inhibitor
    Chemical Name:
    N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
    Molecular Weight:
    570.38
    Molecular Formula:
    C16H16Cl4N2O4S4
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • ISRIB | Integrated stress response inhibitor
    CAS:
    159403-47-8
    Catalog Number:
    10-1539
    Activity:
    Integrated stress response inhibitor
    Chemical Name:
    N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
    Alternate Names:
    trans-ISRIB
    Molecular Weight:
    451.34
    Molecular Formula:
    C22H24Cl2N2O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Hypoxia Products

mTOR

  • INK-128 | TORC1/2 inhibitor
    CAS:
    1224844-38-5
    Catalog Number:
    10-3362
    Activity:
    TORC1/2 inhibitor
    Chemical Name:
    3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    Alternate Names:
    MLN-0128
    Molecular Weight:
    309.33
    Molecular Formula:
    C15H15N7O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC/HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Niclosamide | STAT3 signaling inhibitor
    CAS:
    50-65-7
    Catalog Number:
    10-2474
    Activity:
    STAT3 signaling inhibitor
    Chemical Name:
    5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
    Molecular Weight:
    327.13
    Molecular Formula:
    C13H8Cl2N2O4
    Solubility:
    Soluble in DMSO (up to 3 mg/ml), or in Ethanol (up to 6 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Metformin HCl | Anti-diabetic agent
    CAS:
    1115-70-4
    Catalog Number:
    10-2469
    Activity:
    Anti-diabetic agent
    Chemical Name:
    1,1-Dimethylbiguanide hydrochloride
    Molecular Weight:
    165.63
    Molecular Formula:
    C4H11N5 HCl
    Solubility:
    Soluble in DMSO (up to 8 mg/ml) or in Water (up to 16 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • NVP-BEZ235 | PI3-K and mTOR inhibitor
    CAS:
    915019-65-7
    Catalog Number:
    10-2153
    Activity:
    PI 3-K and mTOR inhibitor
    Chemical Name:
    2-Methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
    Molecular Weight:
    469.55
    Molecular Formula:
    C30H23N5O
    Solubility:
    Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75¡C).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Everolimus | mTOR inhibitor
    CAS:
    159351-69-6
    Catalog Number:
    10-2136
    Activity:
    mTOR inhibitor
    Alternate Names:
    SDZ RAD; RAD001
    Chemical Name:
    40-O-(2-Hydroxyethyl)rapamycin
    Molecular Weight:
    958.25
    Molecular Formula:
    C53H84NO14
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All mTOR Products

NF-kB

  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • Isohelenin | NFkB inhibitor
    CAS:
    470-17-7
    Catalog Number:
    10-5393
    Activity:
    NFkB inhibitor
    Chemical Name:

    (3aR,8aR,9aR)-8a-Methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

    Molecular Weight:
    232.32
    Molecular Formula:
    C15H20O2
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC

    NMR (Conforms)

    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory
    CAS:
    78273-80-0
    Catalog Number:
    10-5046
    Activity:
    Histamine H2 antagonist, antiulcer, anti-inflammatory
    Chemical Name:
    2-Hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
    Molecular Weight:
    306.40
    Molecular Formula:
    C17H26N2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Colorless to pale yellow oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Withaferin A | NFkB and angiogenesis inhibitor
    CAS:
    5119-48-2
    Catalog Number:
    10-2114
    Activity:
    NFκB and angiogenesis inhibitor
    Chemical Name:
    (4β, 5β, 6β, 22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
    Molecular Weight:
    470.60
    Molecular Formula:
    C28H38O6
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    CAS:
    178946-89-9
    Catalog Number:
    10-3280
    Activity:
    Nurr1 activator; NFkB inhibitor
    Chemical Name:
    3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
    Molecular Weight:
    356.85
    Molecular Formula:
    C23H17ClN2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All NF-kB Products

Other

  • 2-AAPA | Glutathione/thioredoxin reductase inhibitor
    CAS:
    1133387-90-2
    Catalog Number:
    10-3238
    Activity:
    Glutathione/thioredoxin reductase inhibitor
    Chemical Names:
    R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
    Molecular Weight:
    518.65
    Molecular Formula:
    C18H22N4O6S4
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
    Shipping Code:
    RT
  • TIC10 | Mitochondrial caseinolytic protease P activator / Anticancer agent
    CAS:
    1616632-77-9
    Catalog Number:
    10-4090
    Activity:
    Mitochondrial caseinolytic protease P activator / Anticancer agent
    Chemical Name:
    7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
    Alternate Name:
    ONC201
    Molecular Weight:
    386.49
    Molecular Formula:
    C24H26N4O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml with warming).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by TLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • C22 Ceramide | MCSR inhibitor
    CAS:
    869501-30-4
    Catalog Number:
    10-1615
    Activity:
    MCSR inhibitor
    Molecular Weight:
    622.06
    Molecular Formula:
    C40H79NO3
    Solubility:
    Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Fascaplysin | CDK4 inhibitor
    CAS:
    114719-57-2
    Catalog Number:
    10-1517
    Activity:
    CDK4 inhibitor
    Chemical Name:
    12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b’]diindol-5-ium chloride
    Molecular Weight:
    306.75
    Molecular Formula:
    C18H11ClN2O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
    Physical Properties:
    Dark red-brown solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Other Products

Oxidative Stress

View All Oxidative Stress Products

p53

  • CBL0137 | Inhibitor of the histone chaperone FACT
    CAS:
    1197996-80-7
    Catalog Number:
    10-4026
  • BMH-21 | RNA Polymerase I inhibitor
    CAS:
    896705-16-1
    Catalog Number:
    10-5688
  • Tenovin-1 | SIRT1/2 inhibitor
    CAS:
    380315-80-0
    Catalog Number:
    10-2982
    Activity:
    SIRT1/2 Inhibitor
    Chemical Names:
    N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
    Molecular Weight:
    369.48
    Molecular Formula:
    C20H23N3O2S
    Solubility:
    Soluble in DMSO (10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RITA | p53 Activator
    CAS:
    213261-59-7
    Catalog Number:
    10-3385
    Activity:
    p53 Activator
    Chemical Names:
    5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol;
    NSC 652287
    Molecular Weight:
    292.37
    Molecular Formula:
    C14H12O3S2
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PRIMA-1(MET) | Reactivates mutant p53
    CAS:
    5291-32-7
    Catalog Number:
    10-4175
    Activity:
    Reactivates mutant p53
    Chemical Name:
    2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
    Alternate Names:
    APR-246
    Molecular Weight:
    199.25
    Molecular Formula:
    C10H17NO3
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    95%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All p53 Products

Programmed cell death

View All Programmed cell death Products

ROS

  • Elesclomol | Copper chelator/Cuproptosis inducer
    CAS:
    488832-69-5
    Catalog Number:
    10-4238
  • Honokiol | SIRT3 activator
    CAS:
    35354-74-6
    Catalog Number:
    10-2311
    Activity:
    SIRT3 activator
    Chemical Names:
    3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
    Alternate Name:
    NSC-293100
    Molecular Weight:
    266.34
    Molecular Formula:
    C18H18O2
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% TLC/GC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • RSL3 | GPX4 inhibitor/Ferroptosis inducer
    CAS:
    1219810-16-8
    Catalog Number:
    10-3417
    Activity:
    GPX4 inhibitor/Ferroptosis inducer
    Chemical Names:
    (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
    Alternate Name:
    1S,3R-RSL3
    Molecular Weight:
    440.88
    Molecular Formula:
    C23H21ClN2O5
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
View All ROS Products

Ubiquitin Proteasome

  • Iberdomide | Cereblon modulator/Molecular glue
    CAS:
    1323403-33-3
    Catalog Number:
    10-3921
  • CC-90009 | Cereblon modulator/Molecular glue
    CAS:
    1860875-51-9
    Catalog Number:
    10-3922
  • ML-792 | SUMO-activating enzyme inhibitor
    CAS:
    1644342-14-2
    Catalog Number:
    10-4985
  • Thiolutin | Inhibitor of the DUB PSMD14
    CAS
    87-11-6
    Catalog Number:
    10-2106
    Activity:
    Inhibitor of the DUB PSMD14
    Chemical Names:
    N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;
    Acetopyrrothin
    Molecular Weight:
    228.29
    Molecular Formula:
    C8H8N2O2S2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • P22077 | Selective USP7 inhibitor
    CAS:
    1247819-59-5
    Catalog Number:
    10-4125
    Activity:
    Selective USP7 inhibitor
    Chemical Name:
    1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
    Molecular Weight:
    315.32
    Molecular Formula:
    C12H7F2NO3S2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Ubiquitin Proteasome Products

UPR

  • GSK2606414 | PERK inhibitor
    CAS:
    1337531-36-8
    Catalog Number:
    10-4716
  • Metolazone | UPR activator and longevity inducer
    CAS:
    17560-51-9
    Catalog Number:
    10-5417
    Activity:
    UPR activator and longevity inducer
    Chemical Name:

    7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

    Molecular Weight:
    365.83
    Molecular Formula:
    C16H16ClN3O3S
    Solubility:
    Soluble in DMSO (up to 36 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Ceapin-A7 | ATF6α/UPR inhibitor
    CAS:
    2323027-38-7
    Catalog Number:
    10-3974
    Activity:
    ATF6α/UPR inhibitor
    Chemical Names:
    N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
    Molecular Weight:
    470.33
    Molecular Formula:
    C20H12F6N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AA147 | ATF6 activator
    CAS:
    393121-74-9
    Catalog Number:
    10-3973
    Activity:
    Activator of ER stress sensing protein ATF6
    Chemical Names:
    N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide; Compound 147
    Molecular Weight:
    255.32
    Molecular Formula:
    C16H17NO2
    Solubility:
    Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
    Physical Properties:
    Beige to pale orange solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Tunicamycin | ER stress inducer
    CAS:
    11089-65-9
    Catalog Number:
    10-2111
    Activity:
    ER stress inducer
    Molecular Weight:
    840.0 (Avg)
    Molecular Formula:
    C38H62N4O16 (tun. B)
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All UPR Products

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