PhysioProcesses

Diabetes

Diabetes is a disease characterized by either the inability to produce enough insulin or a lack of cellular response to insulin. The resulting high blood sugar levels lead to myriad health issues including cardiovascular disease, vision loss, nerve damage, and kidney disease. Current therapies for glycemic control include metformin, sulfonylureas and PPAR-γ agonists. Newer modalities targeting the incretin axis include dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) agonists. A novel method for controlling glucose via the kidneys is inhibition of sodium glucose co-transporter 2 (SGLT2).

Adipogenesis

  • Belumosudil | ROCK2 Inhibitor
    CAS:
    911417-87-3
    Catalog Number:
    10-4165
    Activity:
    Selective Rho kinase 2 (ROCK2) inhibitor
    Chemical Names:
    2-[3-[4-(1H-Indazol-5-yl)amino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide; KD025; SLx-2119
    Molecular Weight:
    452.52
    Molecular Formula:
    C26H24N6O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Formononetin | PPARgamma activator; increases adipocyte thermogenesis
    CAS:
    485-72-3
    Catalog Number:
    10-2252
    Activity:
    PPARγ activator; increases adipocyte thermogenesis
    Chemical Name:
    7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
    Alternate Name:
    7-Hydroxy-4′-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
    Molecular Weight:
    268.26
    Molecular Formula:
    C16H12O4
    Solubility:
    Soluble in DMSO (up to 100 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Obeticholic Acid | FXR agonist
    CAS:
    459789-99-2
    Catalog Number:
    10-2838
    Activity:
    FXR agonist
    Chemical Name:
    3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
    Alternate Names:
    6-Ethylchenodeoxycholic acid; 6-ECDCA
    Molecular Weight:
    420.63
    Molecular Formula:
    C26H44O4
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • BADGE | PPAR gamma antagonist
    CAS:
    1675-54-3
    Catalog Number:
    10-2618
    Activity:
    PPARγ antagonist
    Chemical Name:
    2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
    Alternate Names:
    Bisphenol A diglycidyl ether
    Molecular Weight:
    340.41
    Molecular Formula:
    C21H24O4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White low melting point solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 20(S)-Hydroxycholesterol | Smoothened activator
    CAS:
    516-72-3
    Catalog Number:
    10-4540
    Activity:
    Smoothened activator
    Chemical Name:
    5-Cholesten-3β, 20α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Adipogenesis Products

Adiponectin

  • Miglitol | beta-glucosidase inhibitor / antidiabetic
    CAS:
    72432-03-2
    Catalog Number:
    10-2332
    Activity:
    α-glucosidase inhibitor / antidiabetic
    Alternate Names:
    N-(2-Hydroxyethyl)-1-deoxynojirimycin; BAY-1099
    Chemical Name:
    (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
    Molecular Weight:
    207.23
    Molecular Formula:
    C8H17NO5
    Solubility:
    Soluble in DMSO (up to 50 mg/ml with warming), or in Water (up to 60 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • AdipoRon | Adiponectin agonist
    CAS:
    924416-43-3
    Catalog Number:
    10-1483
    Activity:
    Adiponection agonist
    Chemical Name:
    2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
    Molecular Weight:
    428.54
    Molecular Formula:
    C27H28N2O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Adiponectin Products

Aldose reductase

  • Epalrestat | Aldose reductase inhibitor
    CAS:
    82159-09-9
    Catalog Number:
    10-4423
    Activity:
    Aldose reductase inhibitor
    Alternate Names:
    ONO-2235
    Chemical Name:
    2-[(5Z)-5-[(E)-3-Phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid
    Molecular Weight:
    319.4
    Molecular Formula:
    C15H13NO3S2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    >98% by TLC
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Aldose reductase Products

AMPK

  • Cordycepin | AMPK activator
    CAS:
    73-03-0
    Catalog Number:
    10-2408
    Activity:
    AMPK activator
    Chemical Name:
    3’-Deoxyadenosine
    Alternate Name:
    NSC 63984
    Molecular Weight:
    251.24
    Molecular Formula:
    C10H13N5O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% byHPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Punicalagin | Anti-inflammatory
    CAS:
    65995-63-3
    Catalog Number:
    10-4583
    Activity:
    Anti-inflammatory / antioxidant / anti-tumor agent
    Molecular Weight:
    1084.72
    Molecular Formula:
    C48H28O30
    Solubility:
    Soluble in Water (greater than 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Metformin HCl | Anti-diabetic agent
    CAS:
    1115-70-4
    Catalog Number:
    10-2469
    Activity:
    Anti-diabetic agent
    Chemical Name:
    1,1-Dimethylbiguanide hydrochloride
    Molecular Weight:
    165.63
    Molecular Formula:
    C4H11N5 HCl
    Solubility:
    Soluble in DMSO (up to 8 mg/ml) or in Water (up to 16 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • A-769662 | AMPK activator
    CAS:
    844499-71-4
    Catalog Number:
    10-1171
    Activity:
    AMPK activator
    Chemical Name:
    4-Hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
    Molecular Weight:
    360.39
    Molecular Formula:
    C20H12N2O3S
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AICAR | AMPK activator
    CAS:
    2627-69-2
    Catalog Number:
    10-1092
    Activity:
    AMPK activator
    Alternate Names:
    Acadesine
    Chemical Name:
    5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
    Molecular Weight:
    258.24
    Molecular Formula:
    CH14N4O5
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Water (up to 15 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date  of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All AMPK Products

DPP4

  • Saxagliptin HCl | DPP-IV inhibitor
    CAS:
    709031-78-7
    Catalog Number:
    10-4076
    Activity:
    DPP-IV inhibitor
    Chemical Names:
    (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride; BMS-477118
    Molecular Weight:
    416.45
    Molecular Formula:
    C18H25N3O2·HCl
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Vildagliptin Supplier | DPPIV inhibitor
    CAS:
    274901-16-5
    Catalog Number:
    10-2887
    Activity:
    DPP4 inhibitor
    Chemical Name:
    (S)-1-[N-(3-Hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile
    Alternate Names:
    LAF237
    Molecular Weight:
    303.40
    Molecular Formula:
    C17H25N3O2
    Solubility:
    Soluble in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
  • P32/98 | DPPIV inhibitor
    CAS:
    136259-20-6
    Catalog Number:
    10-1142
    Activity:
    DPPIV inhibitor
    Alternate Names:
    Isoleucine thiazolidide hemi-fumarate
    Chemical Name:
    (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemi-fumarate
    Molecular Weight:
    260.36
    Molecular Formula:
    C9H18N2OS·1/2(C4H4O4)
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Water (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All DPP4 Products

FFAR

  • GW1100 | GPR40 antagonist
    CAS:
    306974-70-9
    Catalog Number:
    10-4516
    Activity:
    GPR40 antagonist
    Chemical Name:
    1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
    Molecular Weight:
    520.59
    Molecular Formula:
    C27H25FN4O4S
    Solubility:
    Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    96% by LCMS
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.
    Shipping Code:
    RT
  • AH-7614 | GPR120 antagonist
    CAS:
    6326-06-3
    Catalog Number:
    10-1521
    Activity:
    GPR120 antagonist
    Chemical Name:
    4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
    Molecular Weight:
    351.43
    Molecular Formula:
    C20H17NO3S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • DC260126 | GPR40 antagonist
    CAS:
    346692-04-4
    Catalog Number:
    10-1531
    Activity:
    GPR40 antagonist
    Chemical Name:
    N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
    Molecular Weight:
    307.37
    Molecular Formula:
    C16H18NO2S
    Solubility:
    Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml).
    Physical Properties:
    Brown waxy solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • GSK-137647 | GPR120 agonist
    CAS:
    349085-82-1
    Catalog Number:
    10-1516
    Activity:
    GPR120 agonist
    Chemical Name:
    4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
    Molecular Weight:
    305.40+L302
    Molecular Formula:
    C16H19NO3S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • GW-9508 | GPR40 agonist
    CAS:
    885101-89-3
    Catalog Number:
    10-1108
    Activity:
    GPR40 agonist
    Chemical Name:
    4-(3-Phenoxybenzylamino)phenylpropionic acid
    Molecular Weight:
    347.42
    Molecular Formula:
    C22H21NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All FFAR Products

Glucose metabolism

  • Mirabegron | beta-3 Adrenergic agonist
    CAS:
    223673-61-8
    Catalog Number:
    10-4228
  • Canagliflozin | SGLT2 inhibitor
    CAS:
    842133-18-0
    Catalog Number:
    10-3576
    Activity:
    SGLT2 inhibitor
    Chemical Names:
    (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol;
    JNJ-24831754
    Molecular Weight:
    444.52
    Molecular Formula:
    C24H25FO5S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • BMS-309403 | FABP4 inhibitor
    CAS:
    300657-03-8
    Catalog Number:
    10-4762
    Activity:
    FABP4 inhibitor
    Chemical Name:
    2-[3-[2-(5-Ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
    Molecular Weight:
    474.55
    Molecular Formula:
    C31H26N2O3
    Solubility:
    Soluble in DMSO (up to at lease 25 mg/ml).
    Physical Properties:
    Off-white or pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Roflumilast | PDE4 inhibitor
    CAS:
    162401-32-3
    Catalog Number:
    10-2657
    Activity:
    PDE4 inhibitor
    Chemical Name:
    3(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide
    Alternate Names:
    BYK-20869
    Molecular Weight:
    403.21
    Molecular Formula:
    C17H14N2Cl2F2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Metformin HCl | Anti-diabetic agent
    CAS:
    1115-70-4
    Catalog Number:
    10-2469
    Activity:
    Anti-diabetic agent
    Chemical Name:
    1,1-Dimethylbiguanide hydrochloride
    Molecular Weight:
    165.63
    Molecular Formula:
    C4H11N5 HCl
    Solubility:
    Soluble in DMSO (up to 8 mg/ml) or in Water (up to 16 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Glucose metabolism Products

GPCRs

  • Efaroxan HCl | α2 adrenergic antagonist
    CAS:
    89197-00-2
    Catalog Number:
    10-1342
    Activity:
    α2 adrenergic antagonist
    Alternate Names:
    RX 821037A
    Chemical Name:
    2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran, hydrochloride
    Molecular Weight:
    252.74
    Molecular Formula:
    C13H16N2O HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All GPCRs Products

GSK-3

  • 6BIO | GSK-3 inhibitor
    CAS:
    667463-62-9
    Catalog Number:
    10-1400
    Activity:
    GSK-3 inhibitor
    Chemical Name:
    (2’Z,3’E)-6-Bromoindirubin-3’oxime
    Molecular Weight:
    356.18
    Molecular Formula:
    C16H10BrN3O2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
    Physical Properties:
    Purple solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • CHIR-99021 | GSK3ß inhibitor
    CAS:
    252917-06-9
    Catalog Number:
    10-1279
    Activity:
    GSK3β inhibitor
    Chemical Name:
    6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
    Molecular Weight:
    465.35
    Molecular Formula:
    C22H18Cl2N8
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • AR-A 014418 | GSK-3 inhibitor
    CAS:
    487021-52-3
    Catalog Number:
    10-1195
    Activity:
    GSK-3 inhibitor
    Chemical Name:
    N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
    Molecular Weight:
    308.32
    Molecular Formula:
    C12H12N4O4S
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All GSK-3 Products

Insulin Receptor

  • BGP-15 | Cellular protectant
    CAS:
    66611-37-8
    Catalog Number:
    10-1373
    Activity:
    Cellular protectant
    Chemical Names:
    N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
    Molecular Weight:
    351.28
    Molecular Formula:
    C14H22N4O2·2HCl
    Solubility:
    Soluble in Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
    Shipping Code:
    RT
  • GSK2656157 | PERK inhibitor
    CAS:
    1337532-29-2
    Catalog Number:
    10-4855
    Activity:
    PERK inhibitor
    Chemical Names:
    1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
    Molecular Weight:
    416.45
    Molecular Formula:
    C23H21FN6O
    Solubility:
    Soluble in DMSO (10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • AS-1949490 | SHIP2 inhibitor
    CAS:
    1203680-76-5
    Catalog Number:
    10-5103
    Activity:
    SHIP2 inhibitor
    Chemical Names:
    3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide
    Molecular Weight:
    371.88
    Molecular Formula:
    C20H18ClNO2S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • 5-Thio-D-glucose | Glucose transport inhibitor
    CAS:
    20408-97-3
    Catalog Number:
    10-1398
    Activity:
    Glucose transport inhibitor
    Chemical Names:

    5-Thio-5-deoxy-D-glucose; 5TG

    Molecular Weight:
    196.22
    Molecular Formula:
    C6H12O5S
    Solubility:
    Soluble in Water (up to 15 mg/ml)
    Physical Properties:
    White solid
    Purity:
    97% HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • BAM15 | Mitochondrial protonophore uncoupler
    CAS:
    210302-17-3
    Catalog Number:
    10-5104
    Activity:
    Mitochondrial protonophore uncoupler
    Chemical Names:
    N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
    Molecular Weight:
    340.29
    Molecular Formula:
    C16H10F2N6O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Insulin Receptor Products

Other Diabetes

View All Other Diabetes Products

PPAR

  • Elafibranor | PPARalpha/delta agonist
    CAS:
    923978-27-2
    Catalog Number:
    10-3901
    Activity:
    PPARalpha/delta agonist
    Chemical Name:
    2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
    Alternate Name:
    GFT505
    Molecular Weight:
    384.49
    Molecular Formula:
    C22H24O4S
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Oleoylethanolamide | GPR119 agonist / stimulates lipolysis
    CAS:
    111-58-0
    Catalog Number:
    10-1475
    Activity:
    GPR119 agonist: Stimulates lipolysis
    Chemical Name:
    N-(2-Hydroxyethyl)-9Z-octadecenamide
    Alternate Names:
    OEA
    Molecular Weight:
    325.53
    Molecular Formula:
    C20H39NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • GW-501516 | PPAR delta agonist
    CAS:
    317318-70-0
    Catalog Number:
    10-1542
    Activity:
    PPAR delta agonist
    Chemical Name:
    2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazoyl]methyl]thio]phenoxy]acetic acid
    Molecular Weight:
    453.50
    Molecular Formula:
    C21H18F3NO3S2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BADGE | PPAR gamma antagonist
    CAS:
    1675-54-3
    Catalog Number:
    10-2618
    Activity:
    PPARγ antagonist
    Chemical Name:
    2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
    Alternate Names:
    Bisphenol A diglycidyl ether
    Molecular Weight:
    340.41
    Molecular Formula:
    C21H24O4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White low melting point solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • MRL-24 | PPAR gamma partial agonist
    Catalog Number:
    10-1365
    CAS:
    393794-17-7
    Activity:
    PPARγ partial agonist
    Chemical Name:
    (S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid
    Molecular Weight:
    527.49
    Molecular Formula:
    C28H24F3NO6
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All PPAR Products

PTP-1B

  • KY-226 | PTP1B inhibitor
    CAS:
    1621673-53-7
    Catalog Number:
    10-4004
    Activity:
    PTP1B Inhibitor
    Chemical Name:
    4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
    Molecular Weight:
    481.67
    Molecular Formula:
    C27H31NO3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All PTP-1B Products

SGLT2

  • Canagliflozin | SGLT2 inhibitor
    CAS:
    842133-18-0
    Catalog Number:
    10-3576
    Activity:
    SGLT2 inhibitor
    Chemical Names:
    (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol;
    JNJ-24831754
    Molecular Weight:
    444.52
    Molecular Formula:
    C24H25FO5S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All SGLT2 Products

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1-855-FOCUS21

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