Nuclear receptors

Nuclear receptors are ligand-gated transcription factors that regulate various physiological processes such as reproduction, inflammation, metabolism, development, and immune function. The 48 human nuclear receptors are controlled by lipophilic signaling molecules: endocrine nuclear receptors bind various steroid hormones, thyroid hormone, or the biologically active forms of vitamins A and D and retinoic acid, adopted orphan nuclear receptors bind to various lipids, metabolic intermediates, or xenobiotics, and orphan receptors have no known endogenous ligand but still operate as transcription factors. Because of their ability to directly interact with and control DNA expression, they play a significant role in cancer, diabetes, immune disorders, and other pathologies.

AhR

  • Laquinimod | Immunomodulator
    CAS:
    248281-84-7
    Catalog Number:
    10-4971
    Activity:
    Immunomodulator
    Chemical Names:
    5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide
    Alternate Name:
    ABR-215062
    Molecular Weight:
    356.81
    Molecular Formula:
    C19H17ClN2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • CH-223191 | Arylhydrocarbon receptor antagonist
    CAS:
    301326-22-7
    Catalog Number:
    10-3089
    Activity:
    Arylhydrocarbon receptor antagonist
    Chemical Name:
    1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
    Molecular Weight:
    333.39
    Molecular Formula:
    C19H19N5O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Cinnabarinic acid | Endogenous AhR ligand
    CAS:
    606-59-7
    Catalog Number:
    10-2883
    Activity:
    Endogenous AhR ligand
    Chemical Name:
    2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
    Alternate Names:
    Cinnabaric acid
    Molecular Weight:
    300.22
    Molecular Formula:
    C14H8N2O6
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • DiMNF | AhR modulator (SAhRM)
    CAS:
    14756-24-2
    Catalog Number:
    10-1557
    Activity:
    AhR modulator (SAhRM)
    Chemical Name:
    2-(3,2-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
    Alternate Names:
    3’,4’-Dimethoxy-α-naphthoflavone
    Molecular Weight:
    332.45
    Molecular Formula:
    C21H16O4
    Solubility:
    Soluble in DMSO (up to 1.5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SR1 | Maintains stem cells in pluripotent state
    CAS:
    1227633-49-9
    Catalog Number:
    10-4508
    Activity:
    Maintains stem cells in pluripotent state
    Molecular Weight:
    466.00
    Molecular Formula:
    C24H23N5OS·HCl
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All AhR Products

Androgen

  • Enzalutamide | Non-steroidal antiandrogen
    CAS:
    915087-33-1
    Catalog Number:
    10-3910
    Activity:
    Non-steroidal antiandrogen
    Chemical Names:
    4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; MDV3100
    Molecular Weight:
    464.44
    Molecular Formula:
    C21H16F4N4O2S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Androgen Products

CAR

  • T0901317 | LXR Agonist
    CAS:
    293754-55-9
    Catalog Number:
    10-3361
  • Oltipraz | Nrf2 activator
    CAS:
    64224-21-1
    Catalog Number:
    10-2831
    Activity:
    Nrf2 activator
    Chemical Name:
    4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
    Molecular Weight:
    226.34
    Molecular Formula:
    C8H6N2S3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • TCPOBOP | CAR agonist
    CAS:
    76150-91-9
    Catalog Number:
    10-1088
    Activity:
    CAR agonist
    Chemical Name:
    1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
    Molecular Weight:
    402.06
    Molecular Formula:
    C16H8Cl4N2O2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
    Shipping Code:
    RT
View All CAR Products

Coactivators

  • Verrucarin A | Steroid receptor coactivator-3 inhibitor
    CAS:
    3148-09-2
    Catalog Number:
    10-3564
  • SI-2 | Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
    CAS:
    380537-35-9
    Catalog Number:
    10-3903
    Activity:
    Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
    Chemical Name:
    1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine
    Molecular Weight:
    265.31
    Molecular Formula:
    C15H15N5
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Pale orange solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Coactivators Products

Cryptochrome

  • KL044 | Cryptochrome stabilizer
    CAS:
    1801856-93-8
    Catalog Number:
    10-3911
  • KL101 | Selective circadian clock protein CRY1 stabilizer
    CAS:
    396721-89-4
    Catalog Number:
    10-3907
    Activity:
    Selective circadian clock protein CRY1 stabilizer
    Chemical Name:

    N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide

    Molecular Weight:
    377.51
    Molecular Formula:
    C22H23N3OS
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • TH301 | Selective circadian clock protein CRY2 stabilizer
    CAS:
    450338-32-6
    Catalog Number:
    10-3909
    Activity:
    Selective circadian clock protein CRY2 stabilizer
    Chemical Name:

    1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

    Molecular Weight:
    485.98
    Molecular Formula:
    C24H24ClN3O4S
    Solubility:
    Soluble in DMSO
    Physical Properties:
    Waxy orange solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • KL-001 | Cryptochrome (CRY) activator
    CAS:
    309928-48-1
    Catalog Number:
    10-1411
    Activity:
    Cryptochrome (CRY) activator
    Chemical Name:
    N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
    Molecular Weight:
    398.46
    Molecular Formula:
    C21H22N2O4S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Cryptochrome Products

ER & ERR

  • SLU-PP-332 | ERR pan-agonist/Exercise mimetic
    CAS:
    303760-60-3
    Catalog Number:
    10-3948
  • DY131 | Estrogen-related receptor ERRbeta and ERRgamma agonist
    CAS:
    95167-41-2
    Catalog Number:
    10-1561
    Activity:
    Estrogen-related receptor ERRbeta and ERRgamma agonist
    Chemical Name:
    N-(4-(Diethylaminobenzylidenyl)-N’-(4-hydroxybenzoyl)-hydrazine
    Alternate Name:
    GSK-9089
    Molecular Weight:
    311.38
    Molecular Formula:
    C18H21N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • DPN |ERß agonist
    CAS:
    1428-67-7
    Catalog Number:
    10-2909
    Activity:
    Estrogen ERβ receptor agonist
    Chemical Name:
    2,3-bis(4-Hydroxyphenyl)-propionitrile
    Alternate Names:
    Diarylpropionitrile
    Molecular Weight:
    239.27
    Molecular Formula:
    C15H13NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    CAS:
    20380-11-4
    Catalog Number:
    10-4536
    Activity:
    Cholesterol oxidation metabolite
    Chemical Name:
    27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Tamoxifen citrate | ER Antagonist/GPR30 agonist
    CAS:
    54965-24-1
    Catalog Number:
    10-1256
    Activity:
    ER Antagonist/GPR30 agonist
    Alternate Names:
    ICI-46474
    Chemical Name:
    (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
    Molecular Weight:
    563.65
    Molecular Formula:
    C26H29NO·C6H8O7
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All ER & ERR Products

FXR

  • T0901317 | LXR Agonist
    CAS:
    293754-55-9
    Catalog Number:
    10-3361
  • Guggulsterone-(Z) | FXR antagonist
    CAS:
    39025-23-5
    Catalog Number:
    10-3816
    Activity:
    FXR antagonist
    Chemical Name:
    (Z)-Pregna-4,17(20)-diene-3,16-dione
    Molecular Weight:
    312.45
    Molecular Formula:
    C21H28O2
    Solubility:
    Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Obeticholic Acid | FXR agonist
    CAS:
    459789-99-2
    Catalog Number:
    10-2838
    Activity:
    FXR agonist
    Chemical Name:
    3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
    Alternate Names:
    6-Ethylchenodeoxycholic acid; 6-ECDCA
    Molecular Weight:
    420.63
    Molecular Formula:
    C26H44O4
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All FXR Products

Glucocorticoid

  • Dexamethasone | Apoptosis inducing glucocorticoid
    CAS:
    50-02-2
    Catalog Number:
    10-1134
    Activity:
    Apoptosis inducing glucocorticoid
    Chemical Name:
    (11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    Molecular Weight:
    392.46
    Molecular Formula:
    C22H29FO5
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
    Shipping Code:
    RT
  • Mifepristone | Glucocorticoid antagonist
    CAS:
    84371-65-3
    Catalog Number:
    10-1053
    Activity:
    Glucocorticoid antagonist
    Alternate Names:
    RU486
    Chemical Name:
    11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
    Molecular Weight:
    429.59
    Molecular Formula:
    C29H35NO2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    >98% by TLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Glucocorticoid Products

LXR

  • T0901317 | LXR Agonist
    CAS:
    293754-55-9
    Catalog Number:
    10-3361
  • 5alpha,6alpha-Epoxycholesterol | LXR ligand
    CAS:
    1250-95-9
    Catalog Number:
    10-4545
    Activity:
    LXR ligand
    Chemical Name:
    Cholestan-5α,6α-epoxy-3β-ol
    Molecular Weight:
    402.65
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SR9243 | LXR inverse agonist
    CAS:
    1613028-81-1
    Catalog Number:
    10-4579
    Activity:
    LXR inverse agonist
    Chemical Name:
    N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3Õ-(methylsulfonyl)[1,1Õ-biphenyl]-4-yl]methyl]-benzenesulfonamide
    Molecular Weight:
    626.62
    Molecular Formula:
    C31H32BrNO4S2
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 20(S)-Hydroxycholesterol | Smoothened activator
    CAS:
    516-72-3
    Catalog Number:
    10-4540
    Activity:
    Smoothened activator
    Chemical Name:
    5-Cholesten-3β, 20α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    CAS:
    20380-11-4
    Catalog Number:
    10-4536
    Activity:
    Cholesterol oxidation metabolite
    Chemical Name:
    27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All LXR Products

Other Nuclear Receptors

  • C-DIM 8 | Nur77 Antagonist
    CAS:
    151358-47-3
    Catalog Number:
    10-5157
    Activity:
    Nur77 antagonist
    Chemical Names:
    1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
    Alternate Name:
    DIM-C-pPhOH
    Molecular Weight:
    338.41
    Molecular Formula:
    C23H18N2O
    Solubility:
    Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
    Physical Properties:
    Pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    CAS:
    178946-89-9
    Catalog Number:
    10-3280
    Activity:
    Nurr1 activator; NFkB inhibitor
    Chemical Name:
    3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
    Molecular Weight:
    356.85
    Molecular Formula:
    C23H17ClN2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • BI-6015 | HNF4α inhibitor
    CAS:
    93987-29-2
    Catalog Number:
    10-1402
    Activity:
    HNF4α inhibitor
    Chemical Name:
    2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
    Molecular Weight:
    331.35
    Molecular Formula:
    C15H13N3O4S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Other Nuclear Receptors Products

PPAR

  • Oleamide | Endogenous sleep-inducing lipid
    CAS:
    301-02-0
    Catalog Number:
    10-2923
    Activity:
    Endogenous sleep-inducing lipid
    Chemical Names:
    9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide
    Molecular Weight:
    281.48
    Molecular Formula:
    C18H35NO
    Solubility:
    Soluble in DMSO (25 mg/ml); Ethanol (40 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • GSK-3787 | PPARδ antagonist
    CAS:
    188591-46-0
    Catalog Number:
    10-1001
    Activity:
    PPARδ antagonist
    Chemical Names:
    4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
    Molecular Weight:
    392.78
    Molecular Formula:
    C15H12ClF3N2O3S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Formononetin | PPARgamma activator; increases adipocyte thermogenesis
    CAS:
    485-72-3
    Catalog Number:
    10-2252
    Activity:
    PPARγ activator; increases adipocyte thermogenesis
    Chemical Name:
    7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
    Alternate Name:
    7-Hydroxy-4′-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
    Molecular Weight:
    268.26
    Molecular Formula:
    C16H12O4
    Solubility:
    Soluble in DMSO (up to 100 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Elafibranor | PPARalpha/delta agonist
    CAS:
    923978-27-2
    Catalog Number:
    10-3901
    Activity:
    PPARalpha/delta agonist
    Chemical Name:
    2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
    Alternate Name:
    GFT505
    Molecular Weight:
    384.49
    Molecular Formula:
    C22H24O4S
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • GW-501516 | PPAR delta agonist
    CAS:
    317318-70-0
    Catalog Number:
    10-1542
    Activity:
    PPAR delta agonist
    Chemical Name:
    2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazoyl]methyl]thio]phenoxy]acetic acid
    Molecular Weight:
    453.50
    Molecular Formula:
    C21H18F3NO3S2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All PPAR Products

Progesterone

  • Mifepristone | Glucocorticoid antagonist
    CAS:
    84371-65-3
    Catalog Number:
    10-1053
    Activity:
    Glucocorticoid antagonist
    Alternate Names:
    RU486
    Chemical Name:
    11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
    Molecular Weight:
    429.59
    Molecular Formula:
    C29H35NO2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    >98% by TLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Progesterone Products

PXR

  • TCPOBOP | CAR agonist
    CAS:
    76150-91-9
    Catalog Number:
    10-1088
    Activity:
    CAR agonist
    Chemical Name:
    1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene
    Molecular Weight:
    402.06
    Molecular Formula:
    C16H8Cl4N2O2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
    Shipping Code:
    RT
View All PXR Products

RAR

  • TTNPB | Retinoid RAR agonist
    CAS:
    71441-28-6
    Catalog Number:
    10-2517
    Activity:
    Retinoid RAR agonist
    Chemical Names:
    4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
    Alternate Name:
    Ro 13-7410; AGN-191183
    Molecular Weight:
    348.49
    Molecular Formula:
    C24H28O3
    Solubility:
    Soluble in DMSO (4 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AR7 | Activates chaperone mediated autophagy
    CAS:
    80306-38-3
    Catalog Number:
    10-5515
    Activity:
    Activates chaperone mediated autophagy
    Chemical Names:
    7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
    Molecular Weight:
    257.72
    Molecular Formula:
    C15H12ClNO
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Pale pink solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • AM-580 | RARα agonist
    CAS:
    102121-60-8
    Catalog Number:
    10-5511
    Activity:
    RARα agonist
    Chemical Names:
    4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055
    Molecular Weight:
    351.45
    Molecular Formula:
    C22H25NO3
    Solubility:
    Soluble in DMSO (35 mg/ml) or ethanol (18 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ro 41-5253 | RARα antagonist
    CAS:
    144092-31-9
    Catalog Number:
    10-4504
    Activity:
    RARα antagonist
    Molecular Weight:
    484.65
    Molecular Formula:
    C28H36O5S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 12 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Retinoic acid | Retinoid RAR agonist
    CAS:
    302-79-4
    Catalog Number:
    10-1138
    Activity:
    Retinoid RAR agonist
    Alternate Names:
    ATRA
    Chemical Name:
    3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid
    Molecular Weight:
    300.44
    Molecular Formula:
    C20H28O2
    Solubility:
    Soluble in DMSO (up to 8 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All RAR Products

Rev-Erb

  • GSK4112 | Rev-Erbα agonist
    CAS:
    1216744-19-2
    Catalog Number:
    10-5493
    Activity:
    Rev-Erbα agonist
    Chemical Names:
    N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester
    Alternate Name:
    SR6452
    Molecular Weight:
    396.89
    Molecular Formula:
    C18H21ClN2O4S
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SR-8278 | REV-ERBα antagonist
    CAS:
    125944-66-5
    Catalog Number:
    10-1506
    Activity:
    REV-ERBα antagonist
    Chemical Name:
    1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
    Molecular Weight:
    361.49
    Molecular Formula:
    C18H19NO3S2
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    White waxy solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SR-9009 | RevErb alpha/beta agonist
    CAS:
    1379686-30-2
    Catalog Number:
    10-1511
    Activity:
    RevErbα/β agonist
    Chemical Name:
    Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
    Molecular Weight:
    474.4
    Molecular Formula:
    C20H24CLN3O4S HCl
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98% by TLC
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Rev-Erb Products

ROR

  • SR3335 | RORα partial inverse agonist
    CAS:
    293753-05-6
    Catalog Number:
    10-4068
  • SR1078 | ROR agonist
    CAS:
    1246525-60-9
    Catalog Number:
    10-4066
  • SR0987 |RORγt agonist
    CAS:
    303126-97-8
    Catalog Number:
    10-4008
    Activity:
    RORγt Agonist/Cancer immunotherapy enhancer
    Chemical Name:
    2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
    Molecular Weight:
    397.70
    Molecular Formula:
    C16H10F6NO2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Nobiletin | Attenuates metabolic syndrome
    CAS:
    478-01-3
    Catalog Number:
    10-4763
    Activity:
    Attenuates metabolic syndrome
    Chemical Name:
    3’,4’,5,6,7,8-Hexamethoxyflavone
    Molecular Weight:
    402.39
    Molecular Formula:
    C21H22O8
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
    CAS:
    474-73-7
    Catalog Number:
    10-1331
    Activity:
    Endogenous cholesterol metabolite
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All ROR Products

RXR

  • Methoprene Acid | Selective RXR agonist
    CAS:
    53092-52-7
    Catalog Number:
    10-4531
    Activity:
    Selective RXR agonist
    Molecular Weight:
    268.39
    Molecular Formula:
    C16H28O3
    Solubility:
    Soluble in DMSO or Ethanol
    Physical Properties:
    Colorless oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Bexarotene | Retinoid RXR agonist
    CAS:
    153559-49-0
    Catalog Number:
    10-2121
    Activity:
    Retinoid RXR agonist
    Alternate Names:
    LGD-1069, SR-11247
    Chemical Name:
    4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
    Molecular Weight:
    348.49
    Molecular Formula:
    C24H28O2
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
    Shipping Code:
    RT
View All RXR Products

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