Kinases

The phosphorylation state of a biologically relevant molecule affects its activity, reactivity, and ability to interact with other molecules. The enzymes responsible for adding phosphate groups, kinases, act on many types of molecules including proteins, lipids, carbohydrates, and nucleotides. These kinases mediate multiple signal transduction pathways and are responsible for modulating many essential cellular functions including metabolism, proliferation, differentiation, and survival. Dysfunction of kinases is involved in many pathological states including cancer, neurodegeneration, inflammation, metabolic and developmental disorders, and autoimmune diseases.

ALK

  • Brigatinib | pan-ALK inhibitor
    CAS:
    1197953-54-0
    Catalog Number:
    10-5034
    Activity:
    pan-ALK inhibitor
    Chemical Names:
    5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4- pyrimidinediamine
    Alternate Name:
    AP26113
    Molecular Weight:
    584.02
    Molecular Formula:
    C29H39ClN7O2P
    Solubility:
    Soluble in DMSO (1 mg/ml with warming)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • GW788388 | TGF-ß receptor kinase inhibitor
    CAS:
    452342-67-5
    Catalog Number:
    10-5521
    Activity:
    TGF-ß receptor kinase inhibitor
    Chemical Names:
    4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
    Molecular Weight:
    425.49
    Molecular Formula:
    C25H23N5O2
    Solubility:
    Soluble in DMSO (18 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Alectinib | Potent and selective ALK inhibitor
    CAS:
    1256580-46-7
    Catalog Number:
    10-4793
    Activity:
    Potent and selective ALK inhibitor
    Chemical Name:
    9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
    Alternate Name:
    CH5424802
    Molecular Weight:
    482.62
    Molecular Formula:
    C30H34N4O2
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
    Shipping Code:
    RT
  • Galunisertib | Potent TGFB receptor 1 inhibitor / Cancer immunotherapeutic
    CAS:
    700874-72-2
    Catalog Number:
    10-4110
    Activity:
    Potent TGF-β receptor 1 inhibitor / Cancer immunotherapeutic
    Chemical Name:
    4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
    Alternate Names:
    LY2157299
    Molecular Weight:
    369.43
    Molecular Formula:
    C22H19N5O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Crizotinib | c-MET and ALK inhibitor
    CAS:
    877399-52-5
    Catalog Number:
    10-2626
    Activity:
    c-MET and ALK inhibitor
    Chemical Name:
    3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
    Alternate Names:
    PF-02341066, PF-1066
    Molecular Weight:
    450.34
    Molecular Formula:
    C21H22Cl2FN5O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All ALK Products

Cell Cycle / Cell Division

  • XL413·HCl | Cdc7 inhibitor/CRISPR enhancer
    CAS:
    2062200-97-7
    Catalog Number:
    10-4414
  • LDN-192960 2HCl | Haspin and DYRK2/3 inhibitor
    CAS:
    184582-62-5
    Catalog Number:
    10-4836
    Activity:
    Haspin and DYRJ2/3 inhibitor
    Chemical Names:
    3-(2,7-Dimethoxyacridin-9-yl)sulfanylpropan-1-amine dihydrochloride
    Molecular Weight:
    401.35
    Molecular Formula:
    C18H20N2O2S·2HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml); Water (2 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SU9516 | pan-specific CDK inhibitor
    CAS:
    SU9516
    Catalog Number:
    10-5705
    Activity:
    pan-specific CDK inhibitor
    Chemical Names:
    (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
    Molecular Weight:
    241.25
    Molecular Formula:
    C13H11N3O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Adavosertib | Wee1 kinase inhibitor
    CAS:
    955365-80-7
    Catalog Number:
    10-4823
    Activity:
    Wee1 kinase inhibitor
    Chemical Names:
    1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
    Alternate Name:
    MK-1775; AZD1775
    Molecular Weight:
    500.61
    Molecular Formula:
    C27H32N8O2
    Solubility:
    Soluble in DMSO (70 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
    CAS:
    142273-20-9
    Catalog Number:
    10-3028
    Activity:
    GSK-3ß/CDK/KLF4 inhibitor
    Chemical Names:
    9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
    Molecular Weight:
    327.18
    Molecular Formula:
    C16H11BrN2O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Cell Cycle / Cell Division Products

DNA Damage Response

  • AZD7648 | DNA-PK inhibitor/CRISPR enhancer
    CAS:
    2230820-11-6
    Catalog Number:
    10-4108
  • VE-821 | Potent and selective ATR inhibitor
    CAS:
    1232410-49-9
    Catalog Number:
    10-5589
    Activity:
    ATR inhibitor
    Chemical Names:
    3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
    Molecular Weight:
    368.41
    Molecular Formula:
    C18H16N4O3S
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • AZ20 | ATR kinase inhibitor
    CAS:
    1233339-22-4
    Catalog Number:
    10-4675
    Activity:
    ATR kinase inhibitor
    Chemical Name:
    4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole
    Molecular Weight:
    412.51
    Molecular Formula:
    C21H24N4O3S
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • NU7441 | DNA-PK inhibitor
    CAS:
    503468-95-9
    Catalog Number:
    10-4810
    Activity:
    DNA-PK inhibitor
    Chemical Name:
    8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
    Alternate Name:
    Ku-57788
    Molecular Weight:
    413.49
    Molecular Formula:
    C25H19NO3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming).
    Physical Properties:
    Off-white to beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • LY2603618 | Potent and selective Chk1 inhibitor
    CAS:
    911222-45-2
    Catalog Number:
    10-4123
    Activity:
    Potent and selective Chk1 inhibitor
    Chemical Name:
    N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)urea
    Alternate Names:
    Rabusertib
    Molecular Weight:
    436.30
    Molecular Formula:
    C18H22BrN5O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All DNA Damage Response Products

ERK

  • Binimetinib | MEK1/2 inhibitor
    CAS:
    606143-89-9
    Catalog Number:
    10-4789
    Activity:
    MEK1/2 inhibitor
    Chemical Name:
    6-(4-Bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
    Alternate Names:
    ARRY-162; MEK162
    Molecular Weight:
    441.23
    Molecular Formula:
    C17H15BrF2N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AZD6244 | ERK inhibitor
    CAS:
    606143-52-6
    Catalog Number:
    10-4509
    Activity:
    ERK inhibitor
    Alternate Names:
    ARRY-142886, Selumetinib
    Molecular Weight:
    457.68
    Molecular Formula:
    C17H15BrClFN4O3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • PD 325901 MEK inhibitor
    CAS:
    391210-10-9
    Catalog Number:
    10-2161
    Activity:
    MEK inhibitor
    Chemical Name:
    N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
    Molecular Weight:
    482.2
    Molecular Formula:
    C16H14F3IN2O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • PD-98059 | MEK inhibitor
    CAS:
    167869-21-8
    Catalog Number:
    10-2159
    Activity:
    MEK inhibitor
    Alternate Names:
    2′-Amino-3′-methoxyflavone
    Chemical Name:
    2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
    Molecular Weight:
    267.29
    Molecular Formula:
    C16H13NO3
    Solubility:
    Soluble in DMSO (up to 6 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All ERK Products

Growth Factor

View All Growth Factor Products

GSK-3b

  • LY2090314 | Wnt/ß-Catenin pathway activator/GSK-3 inhibitor
    CAS:
    603288-22-8
    Catalog Number:
    10-4854
  • Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
    CAS:
    142273-20-9
    Catalog Number:
    10-3028
    Activity:
    GSK-3ß/CDK/KLF4 inhibitor
    Chemical Names:
    9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
    Molecular Weight:
    327.18
    Molecular Formula:
    C16H11BrN2O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • IM-12 | GSK-3ß inhibitor
    CAS:
    1129669-05-1
    Catalog Number:
    10-5125
    Activity:
    GSK-3ß inhibitor
    Chemical Names:
    3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
    Molecular Weight:
    377.41
    Molecular Formula:
    C22H20FN3O2
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SB-216763 | GSK-3 inhibitor
    CAS:
    280744-09-4
    Catalog Number:
    10-2338
    Activity:
    GSK-3 inhibitor
    Chemical Name:
    3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
    Molecular Weight:
    371.23
    Molecular Formula:
    C19H12Cl2N2O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Indirubin-3′-monoxime | GSK-3ß and CDK inhibitor
    CAS:
    160807-49-8
    Catalog Number:
    10-1488
    Activity:
    GSK-3β and CDK inhibitor
    Alternate Names:
    Indirubin-3’oxime
    Chemical Name:
    3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
    Molecular Weight:
    277.29
    Molecular Formula:
    C16H11N3O2
    Solubility:
    Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).
    Physical Properties:
    Dark red or brown solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All GSK-3b Products

Highly Selective Inhibitors

View All Highly Selective Inhibitors Products

Immunoregulatory

View All Immunoregulatory Products

JAK

  • Filgotinib | JAK1 inhibitor
    CAS:
    1206161-97-8
    Catalog Number:
    10-5145
    Activity:
    JAK1 inhibitor
    Chemical Names:
    N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide
    GLPG0634; GS-6034
    Molecular Weight:
    425.50
    Molecular Formula:
    C21H23N5O3S
    Solubility:
    Soluble in DMSO (15 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Pyridone 6 | pan-JAK inhibitor
    CAS:
    457081-03-7
    Catalog Number:
    10-5555
    Activity:
    pan-JAK inhibitor
    Chemical Names:
    2-(tert-Butyl)-9-fluoro-1Hbenzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one; JAK Inhibitor I
    Molecular Weight:
    309.34
    Molecular Formula:
    C18H16FN3O
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Baricitinib | JAK 1/2 inhibitor
    CAS:
    1187594-09-7
    Catalog Number:
    10-3893
    Activity:
    JAK 1/2 inhibitor
    Chemical Name:
    1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile
    Alternate Name:
    INCB028050; LY3009104
    Molecular Weight:
    371.42
    Molecular Formula:
    C16H17N7O2S
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • WP1066 | JAK2/STAT3 inhibitor
    CAS:
    857064-38-1
    Catalog Number:
    10-4831
    Activity:
    JAK2/STAT3 inhibitor
    Chemical Name:
    (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
    Molecular Weight:
    356.22
    Molecular Formula:
    C17H14BrN3O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Ruxolitinib | JAK inhibitor
    CAS:
    941678-49-5
    Catalog Number:
    10-4511
    Activity:
    JAK inhibitor
    Alternate Names:
    INCB 018424
    Chemical Name:
    βR-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
    Molecular Weight:
    306.37
    Molecular Formula:
    C17H18N6
    Solubility:
    Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All JAK Products

JNK

  • JNK-IN-8 | Covalent JNK inhibitor
    CAS:
    1410880-22-6
    Catalog Number:
    10-4780
  • JNK inhibitor IX | JNK inhibitor
    CAS:
    312917-14-9
    Catalog Number:
    10-1528
    Activity:
    JNK inhibitor
    Chemical Name:
    N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide
    Alternate Names:
    TCS JNK 5a
    Molecular Weight:
    332.42
    Molecular Formula:
    C20H16N2OS
    Solubility:
    Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • IQ-1S | JNK3 inhibitor
    CAS:
    1421610-21-0
    Catalog Number:
    10-1513
    Activity:
    JNK3 inhibitor
    Chemical Name:
    11H-Indeno[1,2-b]quinoxaline-11-one oxime, sodium salt
    Molecular Weight:
    269.23
    Molecular Formula:
    C15H8N3O • Na
    Solubility:
    Soluble in DMSO (up to 15 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SR-3576 | JNK3 inhibitor
    CAS:
    1164153-22-3
    Catalog Number:
    10-1498
    Activity:
    JNK3 inhibitor
    Chemical Name:
    3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
    Molecular Weight:
    501.53
    Molecular Formula:
    C27H27N5O5
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SP-600125 | JNK inhibitor
    CAS:
    129-56-6
    Catalog Number:
    10-1033
    Activity:
    JNK inhibitor
    Alternate Names:
    1,9-Pyrazoloanthrone
    Chemical Name:
    Anthra[1-9-cd]pyrazol-6(2H)-one
    Molecular Weight:
    220.23
    Molecular Formula:
    C14H8N2O
    Solubility:
    Soluble in DMSO (up to 22 mg/ml) or in Ethanol (up to 2 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All JNK Products

Metabolic

  • PF-4708671 dihydrochloride | S6K1 inhibitor
    CAS:
    125517-76-0 (free base)
    Catalog Number:
    10-4856
    Activity:
    S6K1 inhibitor
    Chemical Names:
    2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzimidazole dihydrochloride
    Molecular Weight:
    463.33
    Molecular Formula:
    C19H21F3N6·2HCl
    Solubility:
    Soluble in DMSO (at least 35 mg/ml); Water (at least 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month. Hygroscopic solid – protect from moisture.
    Shipping Code:
    RT
  • UNC7467 | IP6K inhibitor
    CAS:
    2922283-43-8
    Catalog Number:
    10-4080
  • PF-543 HCl | Sphingosine kinase-1 inhibitor
    CAS:
    1706522-79-3
    Catalog Number:
    10-4998
  • CBR-470-1 | NRF2 signaling activator
    CAS:
    2416095-06-0
    Catalog Number:
    10-4680
  • IM156 | AMPK activator/Mitochondrial protein complex I inhibitor
    CAS:
    1422365-93-2
    Catalog Number:
    10-4657
    Activity:
    AMPK activator/Mitochondrial complex I inhibitor
    Chemical Names:
    N’-[N’-[4-(Trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboxamidine
    Alternate Name:
    HL156A; Lixumistat
    Molecular Weight:
    315.30
    Molecular Formula:
    C13H16F3N5O
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Metabolic Products

mTOR

  • PP242 | Dual mTORC1/mTORC2 inhibitor
    CAS:
    1092351-67-1
    Catalog Number:
    10-2695
  • PI-103 | Potent inhibitor of PI3-kinase, mTOR, and DNA-PK
    CAS:
    371935-74-9
    Catalog Number:
    10-5406
    Activity:
    Potent inhibitor of PI3-kinase, mTOR and DNA-PK
    Chemical Name:

    3-[4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

    Molecular Weight:
    348.36
    Molecular Formula:
    C19H16N4O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml)
    Physical Properties:
    White solid
    Purity:

    98% by TLC
    NMR (Conforms)

    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Torin1 | mTOR inhibitor
    CAS:
    1222998-36-8
    Catalog Number:
    10-3013
    Activity:
    mTOR inhibitor
    Chemical Name:
    1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
    Molecular Weight:
    607.62
    Molecular Formula:
    C35H28F3N5O2
    Solubility:
    Soluble in DMSO (up to 8 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • INK-128 | TORC1/2 inhibitor
    CAS:
    1224844-38-5
    Catalog Number:
    10-3362
    Activity:
    TORC1/2 inhibitor
    Chemical Name:
    3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    Alternate Names:
    MLN-0128
    Molecular Weight:
    309.33
    Molecular Formula:
    C15H15N7O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC/HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AZD8055 | mTOR kinase inhibitor
    CAS:
    1009298-09-2
    Catalog Number:
    10-4816
    Activity:
    mTOR kinase inhibitor
    Chemical Name:
    (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol
    Molecular Weight:
    465.54
    Molecular Formula:
    C25H31N5O4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All mTOR Products

Multikinase

  • Rebastinib | Bcl-Abl1 inhibitor
    CAS:
    1020172-07-9
    Catalog Number:
    10-4689
  • Nintedanib | VEGFR, PDGFR, and FGFR kinase inhibitor
    CAS:
    656247-17-5
    Catalog Number:
    10-3320
  • HA-100·2HCl | Multi-kinase inhibitor
    CAS:
    85568-24-6
    Catalog Number:
    10-1609
    Activity:
    Multi-kinase inhibitor
    Chemical Names:
    5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
    Molecular Weight:
    350.26
    Molecular Formula:
    C13H15N3O2S·2HCl
    Solubility:
    Soluble in DMSO (30 mg/ml); water (40 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • KW-2449 | Multikinase inhibitor
    CAS:
    1000669-72-6
    Catalog Number:
    10-4448
    Activity:
    Multikinsae inhibitor
    Chemical Names:
    [4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone
    Molecular Weight:
    332.40
    Molecular Formula:
    C20H20N4O
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >97% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Ponatinib | Bcr-Abl and multikinase inhibitor
    CAS:
    943319-70-8
    Catalog Number:
    10-5064
    Activity:
    Bcr-Abl and multikinase inhibitor
    Chemical Name:
    3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
    Alternate Name:
    AP-24534
    Molecular Weight:
    532.56
    Molecular Formula:
    C29H27F32N6O
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date  of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Multikinase Products

Other Kinases

View All Other Kinases Products

p38

  • VX-702 | P38alpha MAP kinase inhibitor
    CAS:
    745833-23-2
    Catalog Number:
    10-2181
    Activity:
    p38alpha MAP kinase inhibitor
    Chemical Name:
    6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
    Molecular Weight:
    404.32
    Molecular Formula:
    C19H12F4N4O2
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Doramapimod | p38 MAPK inhibitor
    CAS:
    285983-48-4
    Catalog Number:
    10-2128
    Activity:
    p38 MAPK inhibitor
    Chemical Name:
    1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea
    Alternate Names:
    BIRB-796
    Molecular Weight:
    527.66
    Molecular Formula:
    C31H37N5O3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • SB 202190 | p38 MAP kinase inhibitor
    CAS:
    152121-30-7
    Catalog Number:
    10-2172
    Activity:
    p38 MAP kinase inhibitor
    Chemical Name:
    4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
    Molecular Weight:
    331.35
    Molecular Formula:
    C20H14N3OF
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • SB 203580 | p38 MAP kinase inhibitor
    CAS:
    152121-47-6
    Catalog Number:
    10-2173
    Activity:
    p38 MAP kinase inhibitor
    Chemical Name:
    4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole
    Molecular Weight:
    377.44
    Molecular Formula:
    C21H16N3OSF
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • LFM-A13 | BTK inhibitor
    CAS:
    244240-24-2
    Catalog Number:
    10-1032
    Activity:
    BTK inhibitor
    Chemical Name:
    (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
    Molecular Weight:
    360
    Molecular Formula:
    C11H8Br2N2O2
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All p38 Products

pan-kinase

  • CZC-8004 | Pan-kinase inhibitor
    CAS:
    916603-07-1
    Catalog Number:
    10-3032
    Activity:
    Multi-kinase inhibitor; affinity ligand
    Chemical Name:
    N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-[yrimidinediamine
    Molecular Weight:
    309.33
    Molecular Formula:
    C17H16FN5
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Staurosporine | Kinase inhibitor (pan-specific)
    CAS:
    62996-74-1
    Catalog Number:
    10-2104
    Activity:
    Kinase inhibitor (pan-specific)
    Molecular Weight:
    466.53
    Molecular Formula:
    C28H26N4O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Off white to pale yellow solid
    Purity:
    >98%
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
    Shipping Code:
    RT
  • K252A | Kinase inhibitor (pan-specific)
    CAS:
    99533-80-9
    Catalog Number:
    10-2080
    Activity:
    Kinase inhibitor (pan-specific)
    Molecular Weight:
    467.49
    Molecular Formula:
    C27H21N3O5
    Solubility:
    Soluble in DMSO (up to 100 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • K252B | Kinase inhibitor (pan-specific)
    CAS:
    99570-78-2
    Catalog Number:
    10-2081
    Activity:
    Kinase inhibitor (pan-specific)
    Molecular Weight:
    453.46
    Molecular Formula:
    C26H19N3O5
    Solubility:
    Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • PKC-412 | Protein kinase inhibitor (pan-specific)
    CAS:
    120685-11-2
    Catalog Number:
    10-1105
    Activity:
    Protein kinase inhibitor (pan-specific.)
    Alternate Names:
    Midostaurin, CGP-41251
    Chemical Name:
    4′-N-Benzoylstaurosporine
    Molecular Weight:
    570.65
    Molecular Formula:
    C35H30N4O4
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All pan-kinase Products

PI3K

  • MTX-531 | Dual EGFR/PI3K inhibitor
    CAS:
    2791417-66-6
    Catalog Number:
    10-4802
  • TGX-221 | Potent and selective PI3Kß inhibitor
    CAS:
    663619-89-4
    Catalog Number:
    10-4783
  • GSK2636771 | Potent and selective inhibitor of PI3Kß
    CAS:
    1372540-25-4
    Catalog Number:
    10-4172
  • Buparlisib | PI3-kinase inhibitor
    CAS:
    944396-07-0
    Catalog Number:
    10-4325
    Activity:
    pan-Class I PI3-kinase inhibitor
    Chemical Names:
    5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine; NVP-BKM120
    Molecular Weight:
    410.39
    Molecular Formula:
    C18H21F3N6O2
    Solubility:
    Soluble in DMSO (15 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PI-103 | Potent inhibitor of PI3-kinase, mTOR, and DNA-PK
    CAS:
    371935-74-9
    Catalog Number:
    10-5406
    Activity:
    Potent inhibitor of PI3-kinase, mTOR and DNA-PK
    Chemical Name:

    3-[4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

    Molecular Weight:
    348.36
    Molecular Formula:
    C19H16N4O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml)
    Physical Properties:
    White solid
    Purity:

    98% by TLC
    NMR (Conforms)

    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All PI3K Products

PKC

  • Teleocidin A1 | Non-phorbol ester PKC activator
    CAS:
    70497-14-2
    Catalog Number:
    10-3339
  • Calphostin C | Protein kinase C inhibitor
    CAS:
    121263-19-2
    Catalog Number:
    10-5635
    Activity:
    Protein Kinase C inhibitor
    Source:
    Fermentation product from Caldisporium cladosporioides
    Alternate Names:
    UNC-1028C; PFK115-584
    Molecular Weight:
    790.77
    Molecular Formula:
    C44H38O14
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Dark red to light brown solid
    Purity:
    >95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Cercosporin | ROS-generating fungal toxin
    CAS:
    35082-49-6
    Catalog Number:
    10-3447
    Activity:
    ROS-generating fungal toxin
    Chemical Names:
    (13bR)-6,12-Dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione
    Alternate Name:
    NSC-153111
    Molecular Weight:
    534.52
    Molecular Formula:
    C29H26O4
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    Dark red solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Intelliscreen™ Protein Kinase C Mini-Library
    Catalog Number:
    10-7320
    Description:
    5 inhibitors of the various PKC isozymes.
    Solubility:
    DMSO
    Supplied As:
    DSMO solution @ 10mM
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $325.00
  • Ingenol-3-angelate | PKC activator
    CAS:
    75567-37-2
    Catalog Number:
    10-1244
    Activity:
    PKC activator
    Alternate Names:
    PEP-005
    Molecular Weight:
    460.53
    Molecular Formula:
    C25H34O6
    Solubility:
    Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All PKC Products

RAF

  • PLX4720 | Mutant B-Raf inhibitor
    CAS:
    918505-84-7
    Catalog Number:
    10-5113
    Activity:
    Mutant B-Raf inhibitor
    Chemical Names:
    N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
    Molecular Weight:
    413.82
    Molecular Formula:
    C17H14ClF2N3O3S
    Solubility:
    Soluble in DMSO (30 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Locostatin | RKIP/Raf-1 kinase disruptor
    CAS:
    133812-16-5
    Catalog Number:
    10-5381
    Activity:
    RKIP/Raf-1 kinase disruptor
    Chemical Names:
    (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005
    Molecular Weight:
    245.28
    Molecular Formula:
    C14H15O3
    Solubility:
    Soluble in DMSO (60 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PLX4032 | BRAF inhibitor
    CAS:
    918504-65-1
    Catalog Number:
    10-2928
    Activity:
    BRAF inhibitor
    Chemical Name:
    N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
    Alternate Names:
    Vemurafenib, R7204, Ro 51-85426
    Molecular Weight:
    489.92
    Molecular Formula:
    C23H18ClF2N3O3S
    Solubility:
    Soluble in DMSO (up to 100 mg/ml)
    Physical Properties:
    White or off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dabrafenib | B-Raf mutant inhibitor
    CAS:
    1195765-45-7
    Catalog Number:
    10-1569
    Activity:
    B-Raf mutant inhibitor
    Chemical Name:
    N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
    Alternate Names:
    GSK2118436
    Molecular Weight:
    519.56
    Molecular Formula:
    C23H20F3N5O2S
    Solubility:
    Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • ZM-336372 | c-Raf inhibitor
    CAS:
    208260-29-1
    Catalog Number:
    10-1030
    Activity:
    c-Raf inhibitor
    Chemical Name:
    3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
    Molecular Weight:
    389.46
    Molecular Formula:
    C23H23N3O3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All RAF Products

SRC

  • Bosutinib | Dual Src/Abl kinase inhibitor
    CAS:
    380843-75-4
    Catalog Number:
    10-2122
    Activity:
    Dual Src/Abl kinase inhibitor
    Chemical Names:
    4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
    Alternate Name:
    SKI-606
    Molecular Weight:
    530.45
    Molecular Formula:
    C26H29Cl2N5O3
    Solubility:
    Soluble in DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • WH-4-023 | Src family kinase inhibitor
    CAS:
    837422-57-8
    Catalog Number:
    10-5124
    Activity:
    Src family kinase inhibitor
    Chemical Names:
    N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid 2,6-dimethylphenyl ester
    Molecular Weight:
    568.67
    Molecular Formula:
    C32H36N6O4
    Solubility:
    Soluble in DMSO (60 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • Saracatinib | Src family kinase inhibitor
    CAS:
    379231-04-6
    Catalog Number:
    10-2901
    Activity:
    Src family kinase inhibitor
    Chemical Names:
    N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; AZD0530
    Molecular Weight:
    542.03
    Molecular Formula:
    C27H32ClN5O5
    Solubility:
    Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dasatinib | Src and Bcr/Abl inhibitor
    CAS:
    302962-49-8
    Catalog Number:
    10-2126
    Activity:
    Src and Bcr/Abl inhibitor
    Alternate Names:
    BMS-354825
    Chemical Name:
    N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide
    Molecular Weight:
    488.01
    Molecular Formula:
    C22H26ClN7O2S
    Solubility:
    Soluble in DMSO (up to 200 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • PP2 | Src family kinase inhibitor
    CAS:
    172889-27-9
    Catalog Number:
    10-1407
    Activity:
    Src family kinase inhibitor
    Chemical Name:
    3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    Molecular Weight:
    301.78
    Molecular Formula:
    C15H16ClN5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
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1-855-FOCUS21

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