Gene regulation

Gene regulation is a broad topic that includes epigenetics, transcription, translation, post-translational modification, protein degradation, and all possible steps in between that affect DNA, RNA, and proteins. Focus Biomolecules offers modulators for each of these categories.

CRISPR

  • Trichostatin A | HDAC inhibitor
    CAS:
    58880-19-6
    Catalog Number:
    10-2110
    Activity:
    HDAC inhibitor
    Alternate Names:
    TSA
    Chemical Name:
    (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    Molecular Weight:
    302.38
    Molecular Formula:
    C17H22N2O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 3 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • XL413·HCl | Cdc7 inhibitor/CRISPR enhancer
    CAS:
    2062200-97-7
    Catalog Number:
    10-4414
  • AZD7648 | DNA-PK inhibitor/CRISPR enhancer
    CAS:
    2230820-11-6
    Catalog Number:
    10-4108
  • Asunaprevir | HCV NS3 protease inhibitor/CRISPR enhancer
    CAS:
    630420-16-5
    Catalog Number:
    10-4928
  • NU7441 | DNA-PK inhibitor
    CAS:
    503468-95-9
    Catalog Number:
    10-4810
    Activity:
    DNA-PK inhibitor
    Chemical Name:
    8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
    Alternate Name:
    Ku-57788
    Molecular Weight:
    413.49
    Molecular Formula:
    C25H19NO3S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming).
    Physical Properties:
    Off-white to beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All CRISPR Products

DNA Polymerase

  • Fludarabine | DNA biosynthesis inhibitor
    CAS:
    21679-14-1
    Catalog Number:
    10-5047
    Activity:
    DNA synthesis inhibitor
    Chemical Names:
    9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218
    Molecular Weight:
    285.23
    Molecular Formula:
    C10H12FN5O4
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Aphidicolin | DNA polymerase inhibitor
    CAS:
    38966-21-1
    Catalog Number:
    10-2058
    Activity:
    DNA polymerase inhibitor
    Chemical Name:
    (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
    Molecular Weight:
    338.48
    Molecular Formula:
    C20H34O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 1 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • 7-Aminoactinomycin D | Fluorescent DNA Probe
    CAS:
    7240-37-1
    Catalog Number:
    10-2053
    Activity:
    Fluorescent DNA probe
    Molecular Weight:
    1270.42
    Molecular Formula:
    C62H87N13O16
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Purple solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions should be made fresh daily.
    Shipping Code:
    RT
  • Gemcitabine HCl | DNA polymerase inhibitor
    CAS:
    122111-03-9
    Catalog Number:
    10-2140
    Activity:
    DNA polymerase inhibitor
    Alternate Names:
    dFdC
    Chemical Name:
    2′-Deoxy-2′,2′-difluorocytidine hydrochloride
    Molecular Weight:
    299.66
    Molecular Formula:
    C9H11F2N3O4 HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All DNA Polymerase Products

DNA Topoisomerase

  • Exatecan mesylate | Topoisomerase I inhibitor
    CAS:
    169869-90-3
    Catalog Number:
    10-5764
  • Ciprofloxacin HCl | Fluoroquinoline antibiotic
    CAS:
    86393-32-0
    Catalog Number:
    10-3917
    Activity:
    Fluoroquinoline antibiotic
    Chemical Names:
    1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinolin-3-carboxylic acid hydrochloride hydrate
    Molecular Weight:
    385.83
    Molecular Formula:
    C17H18FN3O3·HCl·H2O
    Solubility:
    Soluble in water (30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Topotecan HCl | DNA topoisomerase I inhibitor
    CAS:
    119413-54-6
    Catalog Number:
    10-2479
  • ß-Lapachone | Topoisomerase-1 inhibitor
    CAS:
    4707-32-8
    Catalog Number:
    10-2386
    Activity:
    Topoisomerase I inhibitor
    Chemical Name:
    3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
    Alternate Name:
    NSC-26326
    Molecular Weight:
    242.27
    Molecular Formula:
    C15H14O3
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • SN-38 | DNA topoisomerase I inhibitor
    CAS:
    86639-52-3
    Catalog Number:
    10-2425
    Activity:
    DNA topoisomerase I inhibitor
    Chemical Name:
    7-Ethyl-10-hydroxycamptothecin
    Molecular Weight:
    392.41
    Molecular Formula:
    C22H20N2O5
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All DNA Topoisomerase Products

eIF2a

  • ISRIB | Integrated stress response inhibitor
    CAS:
    159403-47-8
    Catalog Number:
    10-1539
    Activity:
    Integrated stress response inhibitor
    Chemical Name:
    N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
    Alternate Names:
    trans-ISRIB
    Molecular Weight:
    451.34
    Molecular Formula:
    C22H24Cl2N2O4
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Salubrinal | eIF2α Phosphatase inhibitor
    CAS:
    405060-95-9
    Catalog Number:
    10-4517
    Activity:
    eIF2α Phosphatase inhibitor
    Chemical Name:
    3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
    Molecular Weight:
    479.81
    Molecular Formula:
    C21H17Cl3N4OS
    Solubility:
    Soluble in DMSO (up to 25 mg/ml),
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All eIF2a Products

Nuclear Receptors

  • GW3965 HCl | LXR agonist
    CAS:
    405911-17-3
    Catalog Number:
    10-3069
  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    CAS:
    178946-89-9
    Catalog Number:
    10-3280
    Activity:
    Nurr1 activator; NFkB inhibitor
    Chemical Name:
    3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
    Molecular Weight:
    356.85
    Molecular Formula:
    C23H17ClN2
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Nuclear Receptors Products

Other Gene Regulation

View All Other Gene Regulation Products

PARP

  • Rucaparib phosphate | PARP1 inhibitor
    CAS:
    459868-92-9
    Catalog Number:
    10-3321
    Activity:
    PARP1 inhibitor
    Chemical Name:
    8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
    Alternate Name:
    AG-14699; PF01367338
    Molecular Weight:
    421.36
    Molecular Formula:
    C19H18FN3O • H3PO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Olaparib | PARP1 inhibitor
    CAS:
    763113-22-0
    Catalog Number:
    10-2154
    Activity:
    PARP1 inhibitor
    Chemical Name:
    4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one
    Alternate Names:
    AZD-2281; KU-59436
    Molecular Weight:
    434.47
    Molecular Formula:
    C24H23FN4O3
    Solubility:
    Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • PJ-34 HCl | PARP1/2 inhibitor
    CAS:
    344458-15-7
    Catalog Number:
    10-2395
    Activity:
    PARP1,2 inhibitor
    Chemical Name:
    N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
    Molecular Weight:
    331.81
    Molecular Formula:
    C17H17N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Water (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • ME-0328 | PARP3 inhibitor
    CAS:
    1445251-22-8
    Catalog Number:
    10-1484
    Activity:
    PARP3 inhibitor
    Chemical Name:
    3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
    Molecular Weight:
    321.38
    Molecular Formula:
    C19H19N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • 3-Aminobenzamide | PARP inhibitor
    CAS:
    3544-24-9
    Catalog Number:
    10-1239
    Activity:
    PARP inhibitor
    Alternate Names:
    3-AB
    Molecular Weight:
    136.15
    Molecular Formula:
    C7H8N2O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 4 mg/ml).
    Physical Properties:
    White to tan solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All PARP Products

Protein Synthesis

  • Actinomycin D | Transcription inhibitor
    CAS:
    50-76-0
    Catalog Number:
    10-2054
    Activity:
    Transcription inhibitor
    Molecular Weight:
    1255.42
    Molecular Formula:
    C62H86N12O16
    Solubility:
    Soluble in DMSO (50 mg/ml).
    Physical Properties:
    Orange-red solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
    Shipping Code:
    RT
  • Puromycin | Translation inhibitor
    CAS:
    58-58-2
    Catalog Number:
    10-2100
    Activity:
    Translation inhibitor
    Chemical Name:
    (S)-3′-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]-amino]-3′-deoxy-N,N-dimethyl-adenosine dihydrochloride
    Molecular Weight:
    544.43
    Molecular Formula:
    C22H29N7O5 2HCl
    Solubility:
    Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
    Physical Properties:
    Tan solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Blasticidin S HCl | Antibiotic selection agent
    CAS:
    3513-03-9
    Catalog Number:
    10-2830
    Activity:
    Blasticidin S HCl
    Chemical Name:
    (S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid hydrochloride
    Molecular Weight:
    458.90
    Molecular Formula:
    C17H26N8O5 &bul; HCl
    Solubility:
    Soluble in Water (greater than 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Cycloheximide | Protein synthesis inhibitor
    CAS:
    66-81-9
    Catalog Number:
    10-1117
    Activity:
    Protein synthesis inhibitor
    Alternate Names:
    U-4527
    Chemical Name:
    4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
    Molecular Weight:
    281.35
    Molecular Formula:
    C15H23NO4
    Solubility:
    Soluble in Ethanol (up to 14 mg/ml) or in Water (up to 7 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    96% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in ethanol or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Florfenicol | Broad-spectrum antibiotic
    CAS:
    73231-34-2
    Catalog Number:
    10-3038
View All Protein Synthesis Products

RNA Polymerase

View All RNA Polymerase Products

Spliceosome

View All Spliceosome Products

Telomerase

  • Cycloastragenol | Telomerase activator/Senolytic agent
    CAS:
    84605-18-5
    Catalog Number:
    10-3715
  • BIBR1532 | Telomerase inhibitor
    CAS:
    321674-73-1
    Catalog Number:
    10-3920
  • Helenalin | NFkB inhibitor
    CAS:
    6754-13-8
    Catalog Number:
    10-2783
    Activity:
    NFκB inhibitor
    Chemical Name:
    Natural sesquiterpenoid from Arnica species
    Molecular Weight:
    262.31
    Molecular Formula:
    C15H18O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Hypericin | Protein kinase C inhibitor
    CAS:
    548-04-9
    Catalog Number:
    10-2077
    Activity:
    Protein kinase C inhibitor
    Chemical Name:
    1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
    Molecular Weight:
    504.45
    Molecular Formula:
    C30H16O8
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Brown solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Telomerase Products

Transcription

View All Transcription Products