Molecular glues are compounds that induce protein-protein interactions between a target protein and ubiquitin ligases leading to target protein degradation via the ubiquitin-proteasome pathway. Glues are more promising “proximity-inducing” agents than heterobifunctional agents (i.e. PROTACS) because of their more drug-like character.
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Ascomycin | FKBP ligand/Immunosuppressant
From $35.00CAS:11011-38-4Catalog Number:10-2059Activity:FKBP ligand; immunosuppressantAlternate Names:FK-520, FR-900520Chemical Name:Fermentation product from Streptomyces hygroscopicusMolecular Weight:729.03Molecular Formula:C43H69NO12Solubility:Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
CR8 3HCl (R) | CDK inhibitor
From $110.00CAS:294646-77-8Catalog Number:10-5507Activity:CDK inhibitorChemical Names:(R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol
Molecular Weight:
540.91Molecular Formula:C24H29N7O ∙3HClSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:White to off-white solidPurity:98% HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Cyclosporin A | Inhibits mitochondrial permeability pore opening
From $50.00CAS:59865-13-3Catalog Number:10-1119Activity:Inhibits mitochondrial permeability pore openingMolecular Weight:1202.65Molecular Formula:C62H111N11O12Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLCStorage Temperature:-20°CStability:Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT