Molecular Glues Archives

Molecular glues are compounds that induce protein-protein interactions between a target protein and ubiquitin ligases leading to target protein degradation via the ubiquitin-proteasome pathway. Glues are more promising “proximity-inducing” agents than heterobifunctional agents (i.e. PROTACS) because of their more drug-like character.

Ascomycin | FKBP ligand/Immunosuppressant

CAS:

11011-38-4

Catalog Number:

10-2059

Activity:

FKBP ligand; immunosuppressant

Alternate Names:

FK-520, FR-900520

Chemical Name:

Fermentation product from Streptomyces hygroscopicus

Molecular Weight:

729.03

Molecular Formula:

C₄₃H₆₉NO₁₂

Solubility:

Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).

Physical Properties:

White solid

Purity:

99% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

RT

From $35.00
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CC-90009 | Cereblon modulator/Molecular glue

CAS:
1860875-51-9
Catalog Number:
10-3922
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CR8 3HCl (R) | CDK inhibitor

CAS:

294646-77-8

Catalog Number:

10-5507

Activity:

CDK inhibitor

Chemical Names:

(R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol

Molecular Weight:
540.91

Molecular Formula:

C₂₄H₂₉N₇O ∙3HCl

Solubility:

Soluble in DMSO (up to 30 mg/ml).

Physical Properties:

White to off-white solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

RT

Stability:

Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

RT

From $110.00
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Cyclosporin A | Inhibits mitochondrial permeability pore opening

CAS:

59865-13-3

Catalog Number:

10-1119

Activity:

Inhibits mitochondrial permeability pore opening

Molecular Weight:

1202.65

Molecular Formula:

C₆₂H₁11N₁₁O₁₂

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

99% by TLC

Storage Temperature:

-20°C

Stability:

Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

RT

From $50.00
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E7820 | RBM39 molecular glue

CAS:
289483-69-8
Catalog Number:
10-3935
View Product This product has multiple variants. The options may be chosen on the product page

Molecular Glues

Ascomycin | FKBP ligand/Immunosuppressant

CC-90009 | Cereblon modulator/Molecular glue

CR8 3HCl (R) | CDK inhibitor

Cyclosporin A | Inhibits mitochondrial permeability pore opening

E7820 | RBM39 molecular glue

EXPLORE OTHER Biochemical Targets

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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Molecular Glues

Ascomycin | FKBP ligand/Immunosuppressant

CC-90009 | Cereblon modulator/Molecular glue

CR8 3HCl (R) | CDK inhibitor

Cyclosporin A | Inhibits mitochondrial permeability pore opening

E7820 | RBM39 molecular glue

EXPLORE OTHER Biochemical Targets

20% OFF

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21