Molecular Glues
Molecular glues are compounds that induce protein-protein interactions between a target protein and ubiquitin ligases leading to target protein degradation via the ubiquitin-proteasome pathway. Glues are more promising “proximity-inducing” agents than heterobifunctional agents (i.e. PROTACS) because of their more drug-like character.
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Lenalidomide | Immunomodulator
From $75.00CAS:191732-72-6Catalog Number:10-2148Activity:ImmunomodulatorChemical Name:(R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dioneMolecular Weight:259.26Molecular Formula:C13H13N3O3Solubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
From $38.00CAS:2188-68-3Catalog Number:10-2608Activity:Protein synthesis inhibitor/SCAP degraderChemical Names:Galanthidine; Amarylline; NarcissineMolecular Weight:323.77Molecular Formula:C16H17NO4·HClSolubility:Soluble in water (15 mg/ml)Physical Properties:White to off-white solidPurity:98% TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Pomalidomide | Cereblon ubiquitination inhibitor
From $50.00CAS:19171-19-8Catalog Number:10-2768Activity:Cereblon ubiquination inhibitorChemical Name:1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamideMolecular Weight:273.24Molecular Formula:C13H11N3O4Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
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