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Molecular Glues

Molecular glues are compounds that induce protein-protein interactions between a target protein and ubiquitin ligases leading to target protein degradation via the ubiquitin-proteasome pathway. Glues are more promising “proximity-inducing” agents than heterobifunctional agents (i.e. PROTACS) because of their more drug-like character.

  • JP-2-196 | Molecular Glue handle

    CAS:
    2913587-31-0
    Catalog Number:
    10-3938
    View Product This product has multiple variants. The options may be chosen on the product page

  • Lenalidomide | Immunomodulator

    CAS:
    191732-72-6
    Catalog Number:
    10-2148
    Activity:
    Immunomodulator
    Chemical Name:
    (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
    Molecular Weight:
    259.26
    Molecular Formula:
    C13H13N3O3
    Solubility:
    Soluble in DMSO (up to 30 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $75.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Lycorine HCl | Protein synthesis inhibitor/SCAP degrader

    CAS:
    2188-68-3
    Catalog Number:
    10-2608
    Activity:
    Protein synthesis inhibitor/SCAP degrader
    Chemical Names:
    Galanthidine; Amarylline; Narcissine
    Molecular Weight:
    323.77
    Molecular Formula:
    C16H17NO4·HCl
    Solubility:
    Soluble in water (15 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $38.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Pomalidomide | Cereblon ubiquitination inhibitor

    CAS:
    19171-19-8
    Catalog Number:
    10-2768
    Activity:
    Cereblon ubiquination inhibitor
    Chemical Name:
    1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
    Molecular Weight:
    273.24
    Molecular Formula:
    C13H11N3O4
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $50.00
    View Product This product has multiple variants. The options may be chosen on the product page

  • Rapamycin | mTOR inhibitor

    CAS:
    53123-88-9
    Catalog Number:
    10-1104
    Activity:
    mTOR inhibitor
    Alternate Names:
    Sirolimus
    Molecular Weight:
    914.17
    Molecular Formula:
    C51H79NO13
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years  from date of purchase as supplied.  Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
    From $52.00
    View Product This product has multiple variants. The options may be chosen on the product page
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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