GPCRs

GPCRs are large, seven-transmembrane receptors in the plasma membrane of the cell. They associate with G proteins, assisting in their GTPase activation and subsequent signal transduction. These pathways involve messengers such as phosphatidylinositol, cyclic AMP (cAMP), and diacylglycerol (DAG) and control important processes like neuronal signaling, cell growth, differentiation, and migration.

Acetylcholine

  • GAT2711 | α9 nAChR agonist
    CAS:
    N/A
    Catalog Number:
    10-4330
  • Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination
    CAS:
    14976-57-9
    Catalog Number:
    10-4644
  • Varenicline tartrate | α4ß2 partial agonist/Smoking cessation aid
    CAS:
    375815-87-5
    Catalog Number:
    10-2362
  • Bupropion HCl | Monoamine transporter inhibitor
    CAS:
    31677-93-7
    Catalog Number:
    10-2462
    Activity:
    Monoamine transporter inhibitor
    Chemical Names:
    1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
    Molecular Weight:
    276.20
    Molecular Formula:
    C13H18ClNO·HCl
    Solubility:
    Soluble in DMSO (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Xanomeline tartrate | M1 muscarinic agonist
    CAS:
    152854-19-8
    Catalog Number:
    10-5112
    Activity:
    M1 muscarinic agonist
    Chemical Names:
    3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine tartrate;
    LY246708 tartrate
    Molecular Weight:
    431.50
    Molecular Formula:
    C14H23N3OS
    Solubility:
    Soluble in DMSO (45 mg/ml) or Water (70 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Acetylcholine Products

Adenosine

  • Preladenant | Potent and selective adenosine A2A antagonist
    CAS:
    377727-87-2
    Catalog Number:
    10-4102
    Chemical Name:
    4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
    Alternate Name:
    SCH 420814
    Molecular Weight:
    503.57
    Molecular Formula:
    C29H29N9O3
    Solubility:
    Soluble in DMSO (up to 5 mg/ml with warming).
    Physical Properties:
    Beige solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • CPI-444 | Adenosine A2A receptor antagonist
    CAS:
    1202402-40-1
    Catalog Number:
    10-4101
    Activity:
    Adenosine A2A receptor antagonist
    Chemical Name:
    7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
    Alternate Name:
    Ciforadenant
    Molecular Weight:
    407.43
    Molecular Formula:
    C20H21N7O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Reversine | Reverses differentiated cells to multipotent stem cells
    CAS:
    656820-32-5
    Catalog Number:
    10-1154
    Activity:
    Reverses differentiated cells to multipotent stem cells
    Chemical Name:
    2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
    Molecular Weight:
    383.5
    Molecular Formula:
    C21H27N7O
    Solubility:
    Soluble in DMSO (up to 7 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All Adenosine Products

Adrenoceptor

  • L-755,507 | ß3 adrenergic agonist/CRISPR efficiency enhancer
    CAS:
    159182-43-1
    Catalog Number:
    10-4229
  • Mirabegron | beta-3 Adrenergic agonist
    CAS:
    223673-61-8
    Catalog Number:
    10-4228
  • Formoterol hemifumarate | ß2 adrenergic agonist
    CAS:
    43229-80-7
    Catalog Number:
    10-5092
    Activity:
    Potent and selective β2 adrenergic agonist
    Chemical Name:
    (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
    Molecular Weight:
    402.44
    Molecular Formula:
    C19H24N2O4·1/2C4H4O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Terazocin HCl | Adrenergic antagonist
    CAS:
    63074-08-8
    Catalog Number:
    10-2379
    Activity:
    Adrenergic antagonist
    Chemical Name:
    1-(4-Amino-6,7-dimethoxy-2-quinazolinyl-4-[(tetrahydro-2-furanyl)carbonyl]piperazine
    Molecular Weight:
    423.88
    Molecular Formula:
    C19H25N5O4
    Solubility:
    Soluble in Water (up to 20 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • CL-316243 | ß3-adrenergic agonist / antiobesity
    CAS:
    151126-84-0
    Catalog Number:
    10-1450
    Activity:
    β3-adrenergic agonist / antiobesity
    Chemical Name:
    5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
    Molecular Weight:
    465.8
    Molecular Formula:
    C20H18ClNNa2O7
    Solubility:
    Soluble in Water (up to 50 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Adrenoceptor Products

Cannabinoid

  • N-Arachidonoyldopamine | Endogenous TRPV1 activator
    CAS:
    199875-69-9
    Catalog Number:
    10-1479
    Activity:
    Endogenous TRPV1 activator
    Chemical Name:
    N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)dopamine
    Alternate Name:
    NADA; AA-DA
    Molecular Weight:
    439.63
    Molecular Formula:
    C28H41NO3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Pale yellow viscous oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -80° (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.
    Shipping Code:
    Blue Ice
  • AM251 | Cannabinoid CB1 antagonist
    CAS:
    183232-66-8
    Catalog Number:
    10-2007
    Activity:
    Cannabinoid CB1 receptor antagonist
    Chemical Name:
    N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
    Molecular Weight:
    555.24
    Molecular Formula:
    C22H21Cl2IN4O
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 13 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dienamide A2 | Novel cannabinoid CB2 agonist/antiinflammatory
    CAS:
    24738-51-0
    Catalog Number:
    10-1621
    Activity:
    Novel cannabinoid CB2 agonist; antiinflammatory
    Chemical Name:
    (2E,4E)-N-Isobutyldodeca-2,4-dienamide
    Molecular Weight:
    251.41
    Molecular Formula:
    C16H29NO
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    Blue Ice
  • WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist
    CAS:
    131543-23-2
    Catalog Number:
    10-2002
    Activity:
    Cannabinoid CB1/CB2 agonist
    Chemical Name:
    (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
    Molecular Weight:
    522.62
    Molecular Formula:
    C27H26N2O3 CH3SO3H
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Anandamide | Endogenous cannabinoid
    CAS:
    94421-68-8
    Catalog Number:
    10-2009
    Activity:
    Endogenous cannabinoid
    Alternate Names:
    Arachidonoylethanolamide; AEA
    Chemical Name:
    N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
    Molecular Weight:
    347.54
    Molecular Formula:
    C22H27NO2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml).
    Physical Properties:
    Colorless oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -80°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
    Shipping Code:
    Blue Ice
View All Cannabinoid Products

Chemokine

  • SX-682 | CXCR1/2 inhibitor
    CAS:
    1648843-04-2
    Catalog Number:
    10-4925
    Activity:
    CXCR1/2 inhibitor
    Chemical Names:
    [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid
    Molecular Weight:
    467.20
    Molecular Formula:
    C19H14BF4N3O4S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AZD2098 | CCR4 antagonist
    CAS:
    566203-88-1
    Catalog Number:
    10-4262
    Activity:
    CCR4 antagonist
    Chemical Names:
    2,3-Dichloro-N-(3-methoxypyrazine-2-yl)benzenesulfonamide
    Molecular Weight:
    334.17
    Molecular Formula:
    C11H9Cl2N3O3S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white/beige solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Plerixafor | CXCR4 antagonist
    CAS:
    155148-31-5
    Catalog Number:
    10-2864
    Activity:
    CXCR4 antagonist
    Molecular Weight:
    794.48
    Molecular Formula:
    C28H54N8 • 8HCl
    Solubility:
    Soluble in Water (up to at least 55 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • PF-4136309 | CCR2 antagonist
    CAS:
    1341224-83-6
    Catalog Number:
    10-4261
    Activity:
    CCR2 antagonist
    Chemical Name:
    N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
    Alternate Name:
    INCB8761
    Molecular Weight:
    568.60
    Molecular Formula:
    C29H31F3N6O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Maraviroc | CCR5 Antagonist
    CAS:
    376348-65-1
    Catalog Number:
    10-4260
    Activity:
    CCR5 Antagonist
    Chemical Name:
    4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
    Alternate Name:
    UK-427,857
    Molecular Weight:
    513.68
    Molecular Formula:
    C29H41F2N5O
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Chemokine Products

Dopamine

  • 9-Hydroxyrisperidone | Risperidone metabolite
    CAS:
    144598-75-4
    Catalog Number:
    10-2300
    Activity:
    Risperidone metabolite
    Chemical Name:
    3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    Alternate Name:
    Paliperidone
    Molecular Weight:
    426.48
    Molecular Formula:
    C23H27FN4O3
    Solubility:
    Soluble in DMSO (up to 4 mg/ml).
    Physical Properties:
    White solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Quetiapine hemifumarate | Atypical antipsychotic agent
    CAS:
    111974-72-2
    Catalog Number:
    10-2587
    Activity:
    Atypical antipsychotic agent
    Chemical Name:
    2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
    Alternate Names:
    ICI-204636
    Molecular Weight:
    441.54
    Molecular Formula:
    C21H25N3O2 • 0.5C4H4O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Perphenazine | Antipsychotic agent
    CAS:
    58-39-9
    Catalog Number:
    10-4709
    Activity:
    Typical antipsychotic
    Chemical Name:
    2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
    Molecular Weight:
    403.98
    Molecular Formula:
    C21H26ClN3OS
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Apomorphine HCl | Dopamine agonist
    CAS:
    41372-20-7
    Catalog Number:
    10-1338
    Activity:
    Dopamine agonist
    Chemical Name:
    (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinolone-10,11-diol hydrochloride
    Alternate Names:
    R-(-)-6aβ-aporphine-10,11-diol hydrochloride Hemihydrate
    Molecular Weight:
    312.78
    Molecular Formula:
    C17H17NO2• HCl 1/2H2O
    Solubility:
    Soluble in Water (up to 20 mg/ml)
    Physical Properties:
    Grey solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
    Shipping Code:
    RT
  • Clozapine | Dopamine D2/D4 antagonist
    CAS:
    5786-21-0
    Catalog Number:
    10-1140
    Activity:
    Dopamine D2/D4 antagonist
    Chemical Name:
    8-Chloro-11-(4-methyl-1-piperazinyl)-5/H-dibenzo[b,e]diazepine
    Molecular Weight:
    326.82
    Molecular Formula:
    C18H19ClN4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Dopamine Products

Estrogen

  • Fulvestrant | Estrogen receptor antagonist
    CAS:
    129453-61-8
    Catalog Number:
    10-2541
    Activity:
    Estrogen receptor antagonist
    Chemical Names:
    7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; ICI- 182,780; ZD-9238
    Molecular Weight:
    606.77
    Molecular Formula:
    C32H47F5O3S
    Solubility:
    Soluble in DMSO (60 mg/mL); Ethanol (30 mg/mL)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • DPN |ERß agonist
    CAS:
    1428-67-7
    Catalog Number:
    10-2909
    Activity:
    Estrogen ERβ receptor agonist
    Chemical Name:
    2,3-bis(4-Hydroxyphenyl)-propionitrile
    Alternate Names:
    Diarylpropionitrile
    Molecular Weight:
    239.27
    Molecular Formula:
    C15H13NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    CAS:
    20380-11-4
    Catalog Number:
    10-4536
    Activity:
    Cholesterol oxidation metabolite
    Chemical Name:
    27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Tamoxifen citrate | ER Antagonist/GPR30 agonist
    CAS:
    54965-24-1
    Catalog Number:
    10-1256
    Activity:
    ER Antagonist/GPR30 agonist
    Alternate Names:
    ICI-46474
    Chemical Name:
    (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
    Molecular Weight:
    563.65
    Molecular Formula:
    C26H29NO·C6H8O7
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Estrogen Products

Free Fatty Acid

  • GW1100 | GPR40 antagonist
    CAS:
    306974-70-9
    Catalog Number:
    10-4516
    Activity:
    GPR40 antagonist
    Chemical Name:
    1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
    Molecular Weight:
    520.59
    Molecular Formula:
    C27H25FN4O4S
    Solubility:
    Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    96% by LCMS
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.
    Shipping Code:
    RT
  • AH-7614 | GPR120 antagonist
    CAS:
    6326-06-3
    Catalog Number:
    10-1521
    Activity:
    GPR120 antagonist
    Chemical Name:
    4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
    Molecular Weight:
    351.43
    Molecular Formula:
    C20H17NO3S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • DC260126 | GPR40 antagonist
    CAS:
    346692-04-4
    Catalog Number:
    10-1531
    Activity:
    GPR40 antagonist
    Chemical Name:
    N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
    Molecular Weight:
    307.37
    Molecular Formula:
    C16H18NO2S
    Solubility:
    Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml).
    Physical Properties:
    Brown waxy solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • GSK-137647 | GPR120 agonist
    CAS:
    349085-82-1
    Catalog Number:
    10-1516
    Activity:
    GPR120 agonist
    Chemical Name:
    4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
    Molecular Weight:
    305.40+L302
    Molecular Formula:
    C16H19NO3S
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • GW-9508 | GPR40 agonist
    CAS:
    885101-89-3
    Catalog Number:
    10-1108
    Activity:
    GPR40 agonist
    Chemical Name:
    4-(3-Phenoxybenzylamino)phenylpropionic acid
    Molecular Weight:
    347.42
    Molecular Formula:
    C22H21NO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Free Fatty Acid Products

GABA

  • Milbemectin | RDL GABA agonist and Glutamate-gated Cl channel activator
    CAS:
    1799297-76-9
    Catalog Number:
    10-5257
  • Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor
    CAS:
    145821-59-6
    Catalog Number:
    10-4384
    Activity:
    GABA transporter 1 (GAT1) inhibitor
    Chemical Name:
    (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
    Alternate Name:
    NO-328
    Molecular Weight:
    412.00
    Molecular Formula:
    C20H25NO2S2 • HCl
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Gaboxadol HCl | GABA-A receptor agonist
    CAS:
    85118-33-8
    Catalog Number:
    10-1168
    Activity:
    GABA-A receptor agonist
    Alternate Names:
    THIP HCl
    Chemical Name:
    4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridine-3-ol hydrochloride
    Molecular Weight:
    176.6
    Molecular Formula:
    C6H8N2O2 HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All GABA Products

Histamine

  • Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination
    CAS:
    14976-57-9
    Catalog Number:
    10-4644
  • Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory
    CAS:
    78273-80-0
    Catalog Number:
    10-5046
    Activity:
    Histamine H2 antagonist, antiulcer, anti-inflammatory
    Chemical Name:
    2-Hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
    Molecular Weight:
    306.40
    Molecular Formula:
    C17H26N2O3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Colorless to pale yellow oil
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Perphenazine | Antipsychotic agent
    CAS:
    58-39-9
    Catalog Number:
    10-4709
    Activity:
    Typical antipsychotic
    Chemical Name:
    2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
    Molecular Weight:
    403.98
    Molecular Formula:
    C21H26ClN3OS
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Astemizole | hERG channel blocker
    CAS:
    68844-77-9
    Catalog Number:
    10-1064
    Activity:
    hERG channel blocker
    Chemical Name:
    1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
    Molecular Weight:
    457.58
    Molecular Formula:
    C28H31FN4O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Histamine Products

Hydroxycarboxylic Acid

  • PSB-1584 | GPR84 agonist
    CAS:
    72255-76-6
    Catalog Number:
    10-5373
    Activity:
    GPR84 agonist
    Chemical Names:
    6-Hexylamino-2,4(1H,3H)-pyrimidinedione, 6-Hexylaminouracil
    Molecular Weight:
    211.26
    Molecular Formula:
    C10H17N3O2
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • IPBT-5CA | GPR109B agonist
    CAS:
    306935-41-1
    Catalog Number:
    10-1070
    Activity:
    GPR109B agonist
    Alternate Names:
    IBC-293
    Chemical Name:
    1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
    Molecular Weight:
    205.22
    Molecular Formula:
    C10H11N2O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Hydroxycarboxylic Acid Products

Leukotriene

  • Montelukast sodium | Leukotriene antagonist and GPR17 antagonist
    CAS:
    151767-02-1
    Catalog Number:
    10-2597
    Activity:
    Leukotriene antagonist and GRP17 antagonist
    Chemical Name:
    2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
    Alternate Names:
    MK-0476
    Molecular Weight:
    608.17
    Molecular Formula:
    C35H35ClNO3S
    Solubility:
    Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
    Physical Properties:
    Solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • BML-111 | LXA agonist/anti-inflammatory
    CAS:
    78606-80-1
    Catalog Number:
    10-3202
    Activity:
    LXA agonist and anti-inflammatory
    Chemical Name:
    (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate
    Molecular Weight:
    192.21
    Molecular Formula:
    C8H16O5
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Zafirlukast | HSP70 inhibitor and leukotriene antagonist
    CAS:
    107753-78-6
    Catalog Number:
    10-1100
    Activity:
    Hsp70 inhibitor
    Alternate Names:
    ICI-204219
    Molecular Weight:
    575.69
    Molecular Formula:
    C31H33N3O6S
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    White or pink solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Zileuton | 5-LO inhibitor
    CAS:
    111406-87-2
    Catalog Number:
    10-1098
    Activity:
    5-LO inhibitor
    Chemical Name:
    N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
    Molecular Weight:
    236.29
    Molecular Formula:
    C11H12N2O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • LY171883 | Cys LT1 antagonist
    CAS:
    88107-10-2
    Catalog Number:
    10-1052
    Activity:
    Cys LT1 antagonist
    Chemical Name:
    1-[2-Hydroxy-3-propyl-4-[4-1H-tetrazol-5-yl)butoxy]phenyl]ethanone
    Molecular Weight:
    318.37
    Molecular Formula:
    C16H22N4O3
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All Leukotriene Products

Lysophosphatidic Acid

  • YL-365 | GPR34 antagonist
    CAS:
    N/A
    Catalog Number:
    10-3988
  • GRI-977143 | LPA2 antagonist
    CAS:
    325850-80-5
    Catalog Number:
    10-1442
    Activity:
    LPA2 antagonist
    Chemical Name:
    2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
    Molecular Weight:
    391.44
    Molecular Formula:
    C22H17NO6S
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • H2L5186303 | LPA2 antagonist
    CAS:
    139262-76-3
    Catalog Number:
    10-1452
    Activity:
    LPA2 antagonist
    Chemical Name:
    (Z,Z)-4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid]
    Molecular Weight:
    488.45
    Molecular Formula:
    C26H202O8
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Lysophosphatidic acid (Oleyl form) | Endogenous LPA receptor agonist
    CAS:
    325465-93-8
    Catalog Number:
    10-1449
    Activity:
    Endogenous LPA receptor agonist
    Alternate Names:
    LPA Na; 1-Oleoyl-lysophosphatidic acid, sodium salt
    Chemical Name:
    1-Oleoyl-2-hydroxy-sn-glycerol-3-phosphate, sodium
    Molecular Weight:
    458.51
    Molecular Formula:
    C21H40O7P
    Solubility:
    Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Lysophosphatidic Acid Products

Metabotropic Glutamate

  • MPEP HCl | mGlu5 Receptor antagonist
    CAS:
    219911-35-0
    Catalog Number:
    10-4007
    Activity:
    mGlu5 receptor antagonist
    Chemical Name:
    2-Methyl-6-(2-phenylethynyl)pyridine hydrochloride
    Molecular Weight:
    229.7
    Molecular Formula:
    C14H11N • HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml)
    Physical Properties:
    White or pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Ibotenic acid | NMDA and mGluR agonist
    CAS:
    2552-55-8
    Catalog Number:
    10-2693
    Activity:
    NMDA and mGluR agonist
    Chemical Name:
    α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate
    Molecular Weight:
    176.13
    Molecular Formula:
    C5H6N2O4 • H2O
    Solubility:
    Soluble in Water (up to 1 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Metabotropic Glutamate Products

Opioid

  • Naloxone HCl | Opioid receptor antagonist
    CAS:
    357-08-4
    Catalog Number:
    10-2442
    Activity:
    Opiod receptor antagonist
    Chemical Name:
    (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
    Molecular Weight:
    363.84
    Molecular Formula:
    C19H21NO4 &bul; HCl
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Nalmefene HCl | Opioid receptor antagonist
    CAS:
    58895-64-0
    Catalog Number:
    10-1049
    Activity:
    Opioid receptor antagonist
    Chemical Name:
    5(α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylene-morphinan-3,14-diol hydrochloride
    Molecular Weight:
    375.82
    Molecular Formula:
    C21H25NO3·HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Opioid Products

Orphan

View All Orphan Products

Other GPCRs

  • SBI-553 | ß-Arrestin-biased NTSR1 modulator
    CAS:
    1849603-72-0
    Catalog Number:
    10-4449
  • Olodanrigan | Angiotensin II type 2 receptor antagonist
    CAS:
    1316755-16-4
    Catalog Number:
    10-4957
  • ML382 | MRGPRX1 positive allosteric modulator
    CAS:
    1646499-97-9
    Catalog Number:
    10-3937
  • PD 123319 ditrifluoroacetate | Angiotensin II type II antagonist
    CAS:
    136676-91-0
    Catalog Number:
    10-4959
    Activity:
    Angiotensin II AT2 antagonist
    Chemical Names:
    (6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
    Molecular Weight:
    736.66
    Molecular Formula:
    C31H32N4O3·2CF3CO2H
    Solubility:
    Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Aprepitant | NK-1 antagonist
    CAS:
    170729-80-3
    Catalog Number:
    10-4366
    Activity:
    NK-1 antagonist
    Chemical Names:
    3-[[(2R,3S)-2-[(1R)-1-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4dihydro-1,2,4-triazol-5-one
    Alternate Name:
    MK-0869
    Molecular Weight:
    534.43
    Molecular Formula:
    C23H21F7N4O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Other GPCRs Products

PAF

  • WEB-2086 | PAF receptor antagonist
    CAS:
    105219-56-5
    Catalog Number:
    10-1389
    Activity:
    PAF receptor antagonist
    Alternate Names:
    Apafant
    Chemical Name:
    4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
    Molecular Weight:
    455.96
    Molecular Formula:
    C22H22ClN5O2S
    Solubility:
    Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Ginkgolide B | PAF receptor antagonist
    CAS:
    15291-77-7
    Catalog Number:
    10-1080
    Activity:
    PAF antagonist
    Alternate Names:
    BN 52021
    Chemical Name:
    Natural product isolated from Ginko biloba
    Molecular Weight:
    424.41
    Molecular Formula:
    C20H24O10
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
    Shipping Code:
    RT
View All PAF Products

Prostanoid

  • Grapiprant | EP4 Receptor antagonist
    CAS:
    415903-37-6
    Catalog Number:
    10-4006
    Activity:
    EP4 Receptor antagonist
    Chemical Name:
    1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
    Alternate Names:
    CJ-023423; ARY-007
    Molecular Weight:
    491.61
    Molecular Formula:
    C26H29N5O3S
    Solubility:
    Soluble in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • TG 4-155 | EP2 receptor antagonist
    CAS:
    1164462-05-8
    Catalog Number:
    10-1574
    Activity:
    EP2 receptor antagonist
    Chemical Name:
    (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
    Molecular Weight:
    394.47
    Molecular Formula:
    C23H26N2O4
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Prostaglandin E2 | Prostaglandin E (EP) receptor agonist
    CAS:
    363-24-6
    Catalog Number:
    10-1358
    Activity:
    Prostaglandin E (EP) receptor agonist
    Alternate Names:
    Dinoprost
    Chemical Name:
    (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
    Molecular Weight:
    352.47
    Molecular Formula:
    C20H32O5
    Solubility:
    Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    Blue Ice
  • SC-51089 | Prostaglandin E2 (EP1) antagonist
    CAS:
    146033-02-5
    Catalog Number:
    10-1135
    Activity:
    PGE2 (EP1 receptor) antagonist
    Chemical Names:
    8-Chlorodibenz(Z)[b,f]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
    Molecular Weight:
    459.34
    Molecular Formula:
    C22H19ClN4O3·HCl
    Solubility:
    Soluble in DMSO (25 mg/ml) or water (25 mg/mL)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • AH-6809 | Prostanoid EP antagonist
    CAS:
    33458-93-4
    Catalog Number:
    10-1050
    Activity:
    Prostanoid EP antagonist
    Chemical Name:
    6-Isopropoxy-9-xanthone-2-carboxylic acid
    Molecular Weight:
    298.29
    Molecular Formula:
    C17H14O5
    Solubility:
    Soluble in DMSO.
    Physical Properties:
    White Solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
    Shipping Code:
    RT
View All Prostanoid Products

Serotonin

  • Ketanserin tartrate | Serotonin 5-HT2A antagonist
    CAS:
    83846-83-7
    Catalog Number:
    10-2490
  • Serodolin | ß-Arrestin-biased 5-HT7 antagonist
    CAS:
    1814929-81-1
    Catalog Number:
    10-4086
    Activity:
    ß-Arrestin-biased 5-HT7 antagonist
    Chemical Names:
    1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazole-2(3H)-one
    Molecular Weight:
    382.47
    Molecular Formula:
    C22H27FN4O
    Solubility:
    Soluble in DMSO (at least 50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Dihydroergotamine mesylate | Vascular serotonin receptor agonist
    CAS:
    6190-39-2
    Catalog Number:
    10-3400
    Activity:
    Vascular serotonin receptor agonist
    Chemical Names:
    (5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
    Molecular Weight:
    679.79
    Molecular Formula:
    C33H37N5O5·CH3SO3H
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Metergoline | Serotonin 5HT1,2,7 antagonist
    CAS:
    17692-51-2
    Catalog Number:
    10-3058
    Activity:
    Serotonin 5HT1,2,7 antagonist
    Chemical Names:
    [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
    Molecular Weight:
    403.52
    Molecular Formula:
    C25H29N3O2
    Solubility:
    Soluble in DMSO (40 mg/ml) or ethanol (4 mg/mL)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethaqnol may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • 9-Hydroxyrisperidone | Risperidone metabolite
    CAS:
    144598-75-4
    Catalog Number:
    10-2300
    Activity:
    Risperidone metabolite
    Chemical Name:
    3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
    Alternate Name:
    Paliperidone
    Molecular Weight:
    426.48
    Molecular Formula:
    C23H27FN4O3
    Solubility:
    Soluble in DMSO (up to 4 mg/ml).
    Physical Properties:
    White solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
View All Serotonin Products

Smoothened

  • Purmorphamine | Smoothened activator
    CAS:
    483367-10-8
    Catalog Number:
    10-4622
    Activity:
    Smoothened activator
    Chemical Name:
    1-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
    Molecular Weight:
    520.62
    Molecular Formula:
    C31H32N6O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • 20(S)-Hydroxycholesterol | Smoothened activator
    CAS:
    516-72-3
    Catalog Number:
    10-4540
    Activity:
    Smoothened activator
    Chemical Name:
    5-Cholesten-3β, 20α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • SAG | Smoothened agonist
    CAS:
    364590-63-6
    Catalog Number:
    10-4525
    Activity:
    Smoothened agonist
    Alternate Names:
    Smoothened Agonist
    Chemical Name:
    3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiiophene-2-carboxamide dihydrochloride
    Molecular Weight:
    562.98
    Molecular Formula:
    C28H28ClN3OS 2HCl
    Solubility:
    Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    Solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Shipping Code:
    RT
  • Jervine | Hedgehog pathway inhibitor
    CAS:
    469-59-0
    Catalog Number:
    10-2388
    Activity:
    Hedgehog pathway
    Alternate Names:
    11-Ketocyclopamine
    Chemical Name:
    (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
    Molecular Weight:
    425.62
    Molecular Formula:
    C27H39NO3
    Solubility:
    Soluble in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol or DMF may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Vismodegib | Sonic Hedgehog signaling pathway inhibitor
    CAS:
    879085-55-9
    Catalog Number:
    10-2182
    Activity:
    Sonic Hedgehog signaling pathway inhibitor
    Chemical Name:
    2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide
    Alternate Names:
    GDC-0449
    Molecular Weight:
    421.3
    Molecular Formula:
    C19H14Cl2N2O3S
    Solubility:
    Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
    Physical Properties:
    Off-white or beige solid
    Purity:
    99% by TLC and HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Smoothened Products

Sphingosine-1-phosphate

  • CYM-5541 | Allosteric sphingosine-1-phosphate receptor 3 agonist
    CAS:
    945128-26-7
    Catalog Number:
    10-4493
    Activity:
    Allosteric sphingosine-1-phosphate receptor 3 agonist
    Chemical Name:
    N,N-Dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
    Alternate Name:
    ML249
    Molecular Weight:
    316.44
    Molecular Formula:
    C19H28N2O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • Sphingosine-1-phosphate | EDG receptor ligand
    CAS:
    26993-30-6
    Catalog Number:
    10-4526
    Activity:
    EDG receptor ligand
    Chemical Name:
    Sphingosine-1-phosphate, D-erythro
    Molecular Weight:
    379.47
    Molecular Formula:
    C18H38NO5P
    Solubility:
    Soluble in anhydrous methanol (up to 0.5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in methanol or in BSA/water may be stored at -20° for up to 2 months. Precipitate may form upon thawing, but will redissolve with warming.
    Shipping Code:
    RT
  • FTY720 HCl | Sphingosine-1-phosphate receptor agonist
    CAS:
    162359-56-0
    Catalog Number:
    10-2138
    Activity:
    Sphingosine-1-phosphate receptor agonist
    Alternate Names:
    Fingolimod
    Chemical Name:
    2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride
    Molecular Weight:
    343.94
    Molecular Formula:
    C19H33NO2 HCl
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Sphingosine-1-phosphate Products

TAAR

  • EPPTB | TAAR1 antagonist
    CAS:
    1110781-88-8
    Catalog Number:
    10-1199
    Activity:
    TAAR1 antagonist
    Chemical Name:
    N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide
    Molecular Weight:
    378.4
    Molecular Formula:
    C20H21F3N2O2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All TAAR Products

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